1I1Q | pdb_00001i1q

STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1i1qa_	Alpha and beta proteins (a+b)	ADC synthase	ADC synthase	ADC synthase	Anthranilate synthase aminodeoxyisochorismate synthase/lyase subunit, TrpE	(Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ],	SCOPe (2.08)
B	d1i1qb_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	Class I glutamine amidotransferases (GAT)	Anthranilate synthase GAT subunit, TrpG	(Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ADC synthase	8021155	4002317	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ADC synthase	8033535	3001093	SCOP2 (2022-06-29)
B	SCOP2 Family	Class I glutamine amidotransferases (GAT)	8021156	4003747	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Class I glutamine amidotransferase-like	8033536	3001405	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Chorismate_bind	e1i1qA1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: Chorismate_bind	ECOD (1.6)
B	GATase	e1i1qB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: GATase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)
B	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00425	chorismate binding enzyme (Chorismate_bind)	chorismate binding enzyme	This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.	Domain
A	PF04715	Anthranilate synthase component I, N terminal region (Anth_synt_I_N)	Anthranilate synthase component I, N terminal region	Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the cho ...	Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (Pfam:PF00425). This region is involved in feedback inhibition by tryptophan [1]. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).	Domain
B	PF00117	Glutamine amidotransferase class-I (GATase)	Glutamine amidotransferase class-I		Domain
B	PF07722	Peptidase C26 (Peptidase_C26)	Peptidase C26	These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C ...	These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C terminus [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ANTHRANILATE SYNTHASE COMPONENT I	cation binding ion binding binding metal ion binding small molecule binding oxo-acid-lyase activity lyase activity anthranilate synthase activity catalytic activity carbon-carbon lyase activity	oxoacid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process indole-containing compound biosynthetic process L-tryptophan metabolic process indolalkylamine metabolic process small molecule metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process indolalkylamine biosynthetic process oxoacid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process indole-containing compound biosynthetic process L-tryptophan metabolic process indolalkylamine metabolic process small molecule metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process indolalkylamine biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process L-tryptophan biosynthetic process proteinogenic amino acid metabolic process amine metabolic process amino acid biosynthetic process biosynthetic process amine biosynthetic process proteinogenic amino acid biosynthetic process metabolic process cellular process erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process biogenic amine metabolic process alpha-amino acid biosynthetic process	-
B	ANTHRANILATE SYNTHASE COMPONENT II	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding oxo-acid-lyase activity lyase activity anthranilate synthase activity catalytic activity carbon-carbon lyase activity pentosyltransferase activity glycosyltransferase activity transferase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding oxo-acid-lyase activity lyase activity anthranilate synthase activity catalytic activity carbon-carbon lyase activity pentosyltransferase activity glycosyltransferase activity transferase activity anthranilate phosphoribosyltransferase activity	antibiotic metabolic process biosynthetic process metabolic process cellular process phenazine biosynthetic process antibiotic biosynthetic process oxoacid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process antibiotic metabolic process biosynthetic process metabolic process cellular process phenazine biosynthetic process antibiotic biosynthetic process oxoacid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process indole-containing compound biosynthetic process L-tryptophan metabolic process indolalkylamine metabolic process small molecule metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process indolalkylamine biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process L-tryptophan biosynthetic process proteinogenic amino acid metabolic process amine metabolic process amino acid biosynthetic process amine biosynthetic process proteinogenic amino acid biosynthetic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process biogenic amine metabolic process alpha-amino acid biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019999	Anthranilate synthase component I-like	Family
A	IPR005257	Anthranilate synthase component I, TrpE-like, bacterial	Family
A	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain
A	IPR006805	Anthranilate synthase component I, N-terminal	Domain
A	IPR005801	ADC synthase	Homologous Superfamily
B	IPR029062	Class I glutamine amidotransferase-like	Homologous Superfamily
B	IPR035902	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily	Homologous Superfamily
B	IPR036320	Glycosyl transferase family 3, N-terminal domain superfamily	Homologous Superfamily
B	IPR006221	Anthranilate synthase/para-aminobenzoate synthase like domain	Domain
B	IPR000312	Glycosyl transferase, family 3	Domain
B	IPR005940	Anthranilate phosphoribosyl transferase	Family
B	IPR017459	Glycosyl transferase family 3, N-terminal domain	Domain
B	IPR017926	Glutamine amidotransferase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.