2AA4 | pdb_00002aa4

Crystal structure of Escherichia coli putative N-ACETYLMANNOSAMINE KINASE, New York Structural Genomics Consortium

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2aa4a1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	ROK	N-acetylmannosamine kinase NanK	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2aa4b1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	ROK	N-acetylmannosamine kinase NanK	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ROK-like	8024419	4000330	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8036800	3000092	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8036798	3000092	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Actin-like ATPases	8036798	3000092	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Actin-like ATPases	8036800	3000092	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ROK_N	e2aa4A1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: ROK_N	ECOD (1.6)
A	ROK_C	e2aa4A2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: ROK_C	ECOD (1.6)
B	ROK_N	e2aa4B1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: ROK_N	ECOD (1.6)
B	ROK_C	e2aa4B2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: ROK_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00480	ROK family (ROK)	ROK family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Putative N-acetylmannosamine kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding N-acylmannosamine kinase activity carbohydrate kinase activity kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding metal ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process N-acetylneuraminate catabolic process carbohydrate derivative catabolic process catabolic process oxoacid metabolic process carboxylic acid metabolic process carbohydrate derivative metabolic process organic acid catabolic process organic acid metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process N-acetylneuraminate catabolic process carbohydrate derivative catabolic process catabolic process oxoacid metabolic process carboxylic acid metabolic process carbohydrate derivative metabolic process organic acid catabolic process organic acid metabolic process amino sugar catabolic process carboxylic acid catabolic process amino sugar metabolic process small molecule metabolic process metabolic process amide metabolic process small molecule catabolic process N-acetylneuraminate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR049874	ROK, conserved site	Conserved Site
A, B	IPR023945	N-acetylmannosamine kinase, bacterial	Family
A, B	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B	IPR000600	ROK family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.