2EE5 | pdb_00002ee5

Solution structure of the N-teruminus extended RhoGAP domain from human Rho GTPase activating protein 5 variant

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ee5a1	All alpha proteins	GTPase activation domain, GAP	GTPase activation domain, GAP	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2ee5a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GTPase activation domain, GAP	8084526	3001163	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RhoGAP	e2ee5A1	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: RhoGAP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.555.10	Mainly Alpha	Orthogonal Bundle	Phosphatidylinositol 3-kinase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00620	RhoGAP domain (RhoGAP)	RhoGAP domain	GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Rho GTPase activating protein 5 variant	protein binding binding SH2 domain binding protein domain specific binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity protein binding binding SH2 domain binding protein domain specific binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	epithelium migration multicellular organismal process tissue migration ameboidal-type cell migration epithelial cell migration cell migration cellular process cell motility cellular component organization regulation of cellular component size biological regulation cellular component organization or biogenesis regulation of biological quality regulation of cell size epithelium migration multicellular organismal process tissue migration ameboidal-type cell migration epithelial cell migration cell migration cellular process cell motility cellular component organization regulation of cellular component size biological regulation cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size positive regulation of mesenchymal cell proliferation regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation positive regulation of biological process regulation of mesenchymal cell proliferation regulation of cell population proliferation mesenchymal cell proliferation positive regulation of cellular process developmental process mammary gland development gland development animal organ development anatomical structure development cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction cell adhesion Rho protein signal transduction positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of epithelial cell migration positive regulation of cell motility regulation of cell migration regulation of multicellular organismal process regulation of epithelial cell migration locomotion regulation of locomotion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032835	Rho GTPase-activating protein, FF domain	Domain
A	IPR051978	Rho GTPase-activating domain-containing protein	Family
A	IPR036517	FF domain superfamily	Homologous Superfamily
A	IPR002713	FF domain	Domain
A	IPR039007	Rho GTPase-activating protein, pG1 domain	Domain
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR039006	Rho GTPase-activating protein, pG2 domain	Domain
A	IPR045786	Rho GTPase-activating protein, pG1 and pG2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13017	ovarian cancer primitive neuroectodermal tumor tuberculosis adenoma breast cancer Emery-Dreifuss muscular dystrophy glioblastoma juvenile dermatomyositis malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis ulcerative colitis amyotrophic lateral sclerosis Crohn disease ovarian cancer primitive neuroectodermal tumor tuberculosis adenoma breast cancer Emery-Dreifuss muscular dystrophy glioblastoma juvenile dermatomyositis malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis ulcerative colitis amyotrophic lateral sclerosis Crohn disease gastric cancer hereditary spastic paraplegia large cell medulloblastoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida atypical teratoid rhabdoid tumor Down syndrome gastric carcinoma invasive ductal breast carcinoma malignant ependymoma myopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.