2GMF | pdb_00002gmf

HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2gmfb1	All alpha proteins	4-helical cytokines	4-helical cytokines	Short-chain cytokines	Granulocyte-macrophage colony-stimulating factor (GM-CSF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2gmfb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2gmfa1	All alpha proteins	4-helical cytokines	4-helical cytokines	Short-chain cytokines	Granulocyte-macrophage colony-stimulating factor (GM-CSF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2gmfa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	4-helical cytokines	8037087	3001717	SCOP2B (2022-06-29)
A	SCOP2 Family	Short-chain cytokines	8024708	4000852	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	4-helical cytokines	8037087	3001717	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	GM_CSF	e2gmfB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: GM_CSF	ECOD (1.6)
A	GM_CSF	e2gmfA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: GM_CSF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
A	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR	protein binding binding signaling receptor binding cytokine receptor binding growth factor receptor binding granulocyte macrophage colony-stimulating factor receptor binding molecular transducer activity molecular function activator activity signaling receptor activity growth factor activity signaling receptor activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity protein binding binding signaling receptor binding cytokine receptor binding growth factor receptor binding granulocyte macrophage colony-stimulating factor receptor binding molecular transducer activity molecular function activator activity signaling receptor activity growth factor activity signaling receptor activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity cytokine activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular response to stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand response to stimulus signal transduction in absence of ligand negative regulation of signaling signaling regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway developmental process multicellular organismal process myeloid leukocyte differentiation cellular developmental process myeloid dendritic cell activation hemopoiesis cell activation cell development mononuclear cell differentiation myeloid leukocyte activation leukocyte activation myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid dendritic cell differentiation dendritic cell differentiation leukocyte differentiation granulocyte differentiation neutrophil differentiation immune response positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process cell surface receptor signaling pathway via STAT rhythmic process circadian sleep/wake cycle, sleep circadian sleep/wake cycle rhythmic behavior regulation of circadian sleep/wake cycle circadian rhythm regulation of circadian rhythm regulation of behavior behavior circadian behavior regulation of multicellular organismal process sleep regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process cell population proliferation localization epithelial fluid transport transport transepithelial transport fluid transport establishment of localization biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin placenta development chordate embryonic development animal organ development embryo development in utero embryonic development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation positive regulation of developmental process foam cell differentiation positive regulation of cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation response to silicon dioxide nitrogen compound transport secretion histamine transport histamine secretion positive regulation of cell population proliferation regulation of cell population proliferation response to peptide response to granulocyte macrophage colony-stimulating factor response to cytokine cellular response to cytokine stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus cell surface receptor signaling pathway via JAK-STAT macrophage differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion cytokine production regulation of cytokine production positive regulation of interleukin-23 production interleukin-23 production positive regulation of multicellular organismal process regulation of interleukin-23 production positive regulation of cytokine production monocyte differentiation positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of podosome assembly membraneless organelle assembly cellular component biogenesis cellular component organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly regulation of podosome assembly protein-containing complex assembly cellular component organization or biogenesis organelle assembly podosome assembly positive regulation of cellular component biogenesis protein-containing complex organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of organelle assembly positive regulation of organelle assembly cytokine-mediated signaling pathway granulocyte-macrophage colony-stimulating factor signaling pathway regulation of leukocyte proliferation leukocyte proliferation positive regulation of leukocyte proliferation response to stress response to fluid shear stress	cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex granulocyte macrophage colony-stimulating factor receptor complex cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex granulocyte macrophage colony-stimulating factor receptor complex receptor complex extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000773	Granulocyte-macrophage colony-stimulating factor	Family
A, B	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P04141	rheumatoid arthritis neutropenia psoriasis thrombocytopenia juvenile myelomonocytic leukemia agranulocytosis plasma cell myeloma melanoma aplastic anemia acute myeloid leukemia pneumonia neural tube defect colorectal cancer spindle cell sarcoma congestive heart failure rheumatoid arthritis neutropenia psoriasis thrombocytopenia juvenile myelomonocytic leukemia agranulocytosis plasma cell myeloma melanoma aplastic anemia acute myeloid leukemia pneumonia neural tube defect colorectal cancer spindle cell sarcoma congestive heart failure thyroid gland carcinoma liver cancer Venous Thrombosis anemia pulmonary fibrosis breast carcinoma sarcoma carcinoma non-alcoholic fatty liver disease thyroid adenoma visceral leishmaniasis bone marrow failure syndrome sarcomatoid carcinoma dissociative amnesia myeloid neoplasm breast cancer cancer schizophrenia hypereosinophilic syndrome idiopathic interstitial pneumonia cutaneous melanoma pancytopenia-developmental delay syndrome diastematomyelia amnestic disorder pneumonitis asthma gastrointestinal mucositis bone marrow disease skin disease colorectal carcinoma craniorachischisis influenza cystic fibrosis peripheral nervous system disease liver neoplasm allergic disease plasma cell neoplasm lymphatic system disease autoimmune disease reticulum cell sarcoma heart failure breast disease neurenteric cyst non-Hodgkin lymphoma inflammatory bowel disease Crohn disease tethered spinal cord syndrome iniencephaly thyroid cancer leukopenia peripheral neuropathy undifferentiated carcinoma epithelioid sarcoma pulmonary alveolar proteinosis eyelid disease lymphosarcoma arthritic joint disease pustulosis palmaris et plantaris autosomal dominant aplasia and myelodysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.