Annotations: 2Q5T

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Exotox-A_bind	e2q5tA6	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Exotox-A_bind	ECOD (1.6)
A	Exotox-A_target	e2q5tA4	A: alpha arrays	X: Toxins' membrane translocation domains	H: Exotoxin A, middle domain (From Topology)	T: Exotoxin A, middle domain	F: Exotox-A_target	ECOD (1.6)
A	Exotox-A_cataly	e2q5tA5	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Exotox-A_cataly	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A	3.90.1350.10	Alpha Beta	Alpha-Beta Complex	Exotoxin A, middle domain	Exotoxin A, middle domain	CATH (4.3.0)
A	3.90.175.10	Alpha Beta	Alpha-Beta Complex	Diphtheria Toxin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09102	Exotoxin A, targeting (Exotox-A_target)	Exotoxin A, targeting	Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for transmembrane targeting of the toxin, as well as transmembrane translocation of the catalytic domain into the cytoplasmic compartment. A furin cleavage sit ...	Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for transmembrane targeting of the toxin, as well as transmembrane translocation of the catalytic domain into the cytoplasmic compartment. A furin cleavage site is present within the domain: cleavage generates a 37 kDa carboxy-terminal fragment, which includes the enzymatic domain, which is then is translocated into the cytoplasm. The domain adopts a helical structure, with six alpha-helices forming a bundle [1].	Domain
A	PF09009	Exotoxin A catalytic (Exotox-A_cataly)	Exotoxin A catalytic	Members of this family, which are found in prokaryotic exotoxin A, catalyse the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cholix toxin	transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups pentosyltransferase activity glycosyltransferase activity NAD+-diphthamide ADP-ribosyltransferase activity toxin activity	symbiont-mediated perturbation of host cellular process regulation of biological process symbiont-mediated activation of host programmed cell death biological process involved in interspecies interaction between organisms regulation of cellular process symbiont-mediated activation of host apoptosis symbiont-mediated perturbation of host programmed cell death biological regulation regulation of killing of cells of another organism disruption of cell in another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process cellular process symbiont-mediated perturbation of host cellular process regulation of biological process symbiont-mediated activation of host programmed cell death biological process involved in interspecies interaction between organisms regulation of cellular process symbiont-mediated activation of host apoptosis symbiont-mediated perturbation of host programmed cell death biological regulation regulation of killing of cells of another organism disruption of cell in another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process cellular process regulation of cell killing symbiont-mediated perturbation of host apoptosis disruption of anatomical structure in another organism modulation of process of another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036478	Exotoxin A, middle domain superfamily	Homologous Superfamily
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR015099	Exotoxin A catalytic domain	Domain
A	IPR015185	Exotoxin A, binding	Domain
A	IPR015186	Exotoxin A, middle domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.