Annotations: 4AQT

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_N	e4aqtA12	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
A	Laminin_EGF_1	e4aqtA11	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
A	Laminin_EGF_2	e4aqtA10	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00053	Laminin EGF domain (EGF_laminin)	Laminin EGF domain	This family is like Pfam:PF00008 but has 8 conserved cysteines instead of six.	Domain
A	PF00055	Laminin N-terminal (Domain VI) (Laminin_N)	Laminin N-terminal (Domain VI)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	LAMININ SUBUNIT GAMMA-1	glycosphingolipid binding binding sphingolipid binding lipid binding glycolipid binding carbohydrate derivative binding structural molecule activity extracellular matrix structural constituent	developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis regulation of biological process regulation of cellular process regulation of developmental process biological regulation positive regulation of biological process regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation positive regulation of cellular process cell junction organization cell junction assembly cell-substrate junction assembly cell-substrate junction organization hemidesmosome assembly cellular component disassembly extracellular matrix disassembly extracellular matrix organization extracellular structure organization external encapsulating structure organization molting cycle process hair cycle epidermis morphogenesis animal organ development morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis skin development skin epidermis development hair follicle development molting cycle hair cycle process hair follicle morphogenesis cell migration cell motility hair follicle cell proliferation cell population proliferation cell adhesion positive regulation of cell adhesion regulation of cell adhesion cellular response to stimulus positive regulation of cell communication regulation of integrin-mediated signaling pathway positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of integrin-mediated signaling pathway signal transduction regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular component organization regulation of basement membrane organization regulation of extracellular matrix organization basement membrane organization plasma membrane bounded cell projection organization cell projection organization cell development neuron projection development neuron development chromatin organization	basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix laminin-10 complex laminin complex protein-containing complex synaptic cleft extracellular region neuromuscular junction synapse cell junction basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix laminin-10 complex laminin complex protein-containing complex synaptic cleft extracellular region neuromuscular junction synapse cell junction protein complex involved in cell-matrix adhesion protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008211	Laminin, N-terminal	Domain
A	IPR002049	Laminin-type EGF domain	Domain
A	IPR000742	EGF-like domain	Domain
A	IPR050440	Laminin/Netrin Extracellular Matrix	Family
A	IPR000034	Laminin IV	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.