4NZW | pdb_00004nzw

Crystal Structure of STK25-MO25 Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8041962	3000116	SCOP2B (2022-06-29)
B	SCOP2 Family	Protein kinases catalytic domain-like	8062554	4003661	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Protein kinase-like (PK-like)	8062555	3000066	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Mo25	e4nzwA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mo25	ECOD (1.6)
B	Pkinase_Tyr	e4nzwB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Calcium-binding protein 39	protein binding binding kinase binding enzyme binding enzyme regulator activity catalytic activity, acting on a protein molecular function activator activity kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups kinase activator activity protein binding binding kinase binding enzyme binding enzyme regulator activity catalytic activity, acting on a protein molecular function activator activity kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity catalytic activity kinase regulator activity protein serine/threonine kinase activity protein serine/threonine kinase activator activity	regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process potassium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process potassium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport localization negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transport regulation of monoatomic ion transmembrane transporter activity regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation negative regulation of transporter activity negative regulation of molecular function inorganic ion transmembrane transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport cellular process regulation of monoatomic cation transmembrane transport response to thyroid hormone response to stimulus response to hormone response to endogenous stimulus response to chemical positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-threonine phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process peptidyl-threonine modification positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process peptidyl-threonine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity response to activity cellular response to stimulus signaling signal transduction intracellular signal transduction cell communication response to osmotic stress cellular hypotonic response cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus hypotonic response cellular response to chemical stimulus cellular response to stress response to stress response to abiotic stimulus cellular response to abiotic stimulus	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen secretory granule secretory vesicle protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex cytosol ficolin-1-rich granule ficolin-1-rich granule lumen
B	Serine/threonine-protein kinase 25	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity cation binding metal ion binding histone H2BS14 kinase activity histone H2B kinase activity histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity identical protein binding protein binding protein homodimerization activity protein dimerization activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intracellular signaling cassette signal transduction positive regulation of stress-activated protein kinase signaling cascade positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of stress-activated MAPK cascade positive regulation of MAPK cascade biological regulation regulation of stress-activated protein kinase signaling cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus MAPK cascade regulation of cell communication cellular process positive regulation of signaling multicellular organismal process positive regulation of nervous system development axonogenesis cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to oxidative stress cellular response to chemical stress protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process intrinsic apoptotic signaling pathway in response to oxidative stress programmed cell death in response to reactive oxygen species cellular response to reactive oxygen species hydrogen peroxide-mediated programmed cell death intrinsic apoptotic signaling pathway response to oxygen-containing compound intrinsic apoptotic signaling pathway in response to hydrogen peroxide cell death cellular response to oxygen-containing compound response to reactive oxygen species apoptotic signaling pathway apoptotic process programmed cell death establishment or maintenance of cell polarity Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell establishment of localization Golgi inheritance organelle inheritance Golgi reassembly cellular component biogenesis organelle organization cellular component assembly Golgi organization endomembrane system organization	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm intracellular organelle Golgi apparatus extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system FAR/SIN/STRIPAK complex protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR013878	Mo25-like	Family
B	IPR046409	Programmed cell death protein 10, dimerisation domain superfamily	Homologous Superfamily
B	IPR000719	Protein kinase domain	Domain
B	IPR048288	Programmed cell death protein 10, dimerisation domain	Domain
B	IPR035060	Serine/threonine kinase 25, catalytic domain	Domain
B	IPR017441	Protein kinase, ATP binding site	Binding Site
B	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase	Family
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y376	atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma hereditary spastic paraplegia lymphoplasmacytic lymphoma ovarian cancer IgA glomerulonephritis medulloblastoma ulcerative colitis
B	Pharos: O00506	diabetes mellitus ovarian cancer HER2-positive carcinoma of breast prostate carcinoma inflammatory bowel disease vitiligo

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.