Annotations: 5EG6

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth C]	TIG_7	e5eg6C3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: TIG_7	ECOD (1.6)
B [auth C]	LAG1-DNAbind	e5eg6C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: LAG1-DNAbind	ECOD (1.6)
B [auth C]	BTD	e5eg6C1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: BTD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth C]	2.60.40.1450	Mainly Beta	Sandwich	Immunoglobulin-like	LAG1, DNA binding domain	CATH (4.3.0)
B [auth C]	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth C]	PF20144	TIG domain (TIG_SUH)	TIG domain	This entry represents a TIG-like domain found in the suppressor of hairless protein.	Domain
B [auth C]	PF09270	Beta-trefoil DNA-binding domain (BTD)	Beta-trefoil DNA-binding domain	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and ...	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) [1].	Domain
B [auth C]	PF09271	LAG1, DNA binding (LAG1-DNAbind)	LAG1, DNA binding	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1]. Th ...	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1]. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA (5'-D(APAPTPCPTPTPTPCPCPCPAPCPAPGP*T)-3')	-	-	-
B [auth C]	Recombining binding protein suppressor of hairless	sequence-specific DNA binding DNA binding binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding double-stranded DNA binding sequence-specific DNA binding DNA binding binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of ephrin receptor signaling pathway regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus signal transduction enzyme-linked receptor protein signaling pathway cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of ephrin receptor signaling pathway regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway positive regulation of ephrin receptor signaling pathway biological regulation regulation of response to stimulus regulation of cell communication cellular process ephrin receptor signaling pathway positive regulation of signaling developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cardiac chamber morphogenesis heart morphogenesis ventricular septum development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development atrioventricular canal development heart formation specification of animal organ identity pattern specification process regionalization anatomical structure formation involved in morphogenesis secondary heart field specification animal organ formation heart field specification regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process regulation of growth positive regulation of cell population proliferation regulation of developmental process regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth striated muscle tissue development positive regulation of developmental process positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth positive regulation of heart growth striated muscle cell proliferation heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth growth tissue development positive regulation of growth regulation of cell population proliferation positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of transcription of Notch receptor target regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process Notch signaling pathway positive regulation of RNA biosynthetic process cellular developmental process hemopoiesis cell differentiation cell development blood vessel morphogenesis tube development artery development vasculature development tube morphogenesis artery morphogenesis blood vessel development biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus head development forebrain development endocrine system development pituitary gland development gland development brain development diencephalon development nervous system development central nervous system development heart valve development pulmonary valve development semi-lunar valve development negative regulation of cell population proliferation regulation of stem cell proliferation negative regulation of biological process negative regulation of stem cell proliferation stem cell proliferation negative regulation of cellular process regulation of cell adhesion cell adhesion involved in heart morphogenesis cell adhesion regulation of cell adhesion involved in heart morphogenesis regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy skin development sebaceous gland development epithelium development respiratory tube development lung epithelium development epithelial cell differentiation lung epithelial cell differentiation lung cell differentiation lung development respiratory system development club cell differentiation mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition immune response immune system process inflammatory response inflammatory response to antigenic stimulus cell fate commitment somatic stem cell population maintenance maintenance of cell number stem cell population maintenance negative regulation of developmental process regulation of cell differentiation negative regulation of cell differentiation negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process endocardial cushion morphogenesis endocardial cushion development cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation mesenchyme morphogenesis endocardial cushion formation tissue morphogenesis heart induction developmental induction regulation of anatomical structure morphogenesis regulation of animal organ morphogenesis positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction regulation of heart morphogenesis embryo development embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry epithelial tube morphogenesis embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis embryonic morphogenesis morphogenesis of an epithelium determination of heart left/right asymmetry left/right pattern formation ventricular cardiac muscle tissue morphogenesis muscle structure development ventricular cardiac muscle tissue development ventricular trabecula myocardium morphogenesis muscle organ development muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis heart trabecula morphogenesis trabecula morphogenesis muscle organ morphogenesis regulation of development, heterochronic regulation of timing of cell differentiation epidermal cell differentiation epidermis development keratinocyte differentiation B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation leukocyte differentiation labyrinthine layer blood vessel development placenta blood vessel development placenta development chordate embryonic development labyrinthine layer development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching myeloid leukocyte differentiation myeloid dendritic cell activation myeloid leukocyte activation myeloid cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation angiogenesis humoral immune response somitogenesis segmentation anterior/posterior pattern specification somite development endothelial cell fate commitment endothelium development epithelial cell fate commitment endothelial cell fate specification blood vessel endothelial cell differentiation blood vessel endothelial cell fate commitment endothelial cell differentiation cell fate specification blood vessel endothelial cell fate specification positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation generation of neurons neurogenesis neuron differentiation arterial endothelial cell fate commitment arterial endothelial cell differentiation epidermal cell fate specification endocardium development endocardium morphogenesis cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of BMP signaling pathway cellular response to endogenous stimulus BMP signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor positive regulation of cell proliferation involved in heart morphogenesis cell proliferation involved in heart morphogenesis regulation of cell proliferation involved in heart morphogenesis cardiac left ventricle morphogenesis blood vessel remodeling tissue remodeling molting cycle process hair cycle developmental maturation anatomical structure maturation skin epidermis development hair follicle development molting cycle hair cycle process hair follicle maturation morphogenesis of an endothelium endothelial tube morphogenesis blood vessel lumenization positive regulation of ERBB signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway aortic valve development cardiac muscle cell myoblast differentiation cardiocyte differentiation cardioblast differentiation stem cell differentiation myoblast differentiation regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of cold-induced thermogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis negative regulation of multicellular organismal process ossification regulation of ossification negative regulation of ossification sensory organ development hair cell differentiation auditory receptor cell fate commitment inner ear development mechanoreceptor differentiation ear development inner ear receptor cell fate commitment neuron fate commitment inner ear auditory receptor cell differentiation inner ear receptor cell differentiation aorta morphogenesis aorta development dorsal aorta morphogenesis dorsal aorta development outflow tract morphogenesis	protein-containing complex transcription regulator complex cellular anatomical structure intracellular anatomical structure cytoplasm MAML1-RBP-Jkappa- ICN1 complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle protein-containing complex transcription regulator complex cellular anatomical structure intracellular anatomical structure cytoplasm MAML1-RBP-Jkappa- ICN1 complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen nucleoplasm transcription repressor complex
C [auth R]	hRITA	cytoskeletal protein binding protein binding binding tubulin binding	localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process nuclear export establishment of localization regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process nuclear export establishment of localization regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process developmental process neurogenesis multicellular organism development multicellular organismal process cellular developmental process cell differentiation anatomical structure development nervous system development system development cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction negative regulation of signaling regulation of signal transduction negative regulation of cell communication regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen centrosome cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton
D [auth A]	DNA (5'-D(TPTPAPCPTPGPTPGPGPGPAPAPAPGP*A)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth C]	IPR037095	RBP-J/Cbf11, DNA binding domain superfamily	Homologous Superfamily
B [auth C]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B [auth C]	IPR040159	Suppressor of hairless-like	Family
B [auth C]	IPR036358	Beta-trefoil domain superfamily	Homologous Superfamily
B [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth C]	IPR015350	Beta-trefoil DNA-binding domain	Domain
B [auth C]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B [auth C]	IPR015351	RBP-J/Cbf11/Cbf12, DNA binding	Domain
B [auth C]	IPR038007	RBP-Jkappa, IPT domain	Domain
C [auth R]	IPR031418	RBPJ-interacting and tubulin-associated protein 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth R]	Pharos: Q96K30	astrocytic tumor ovarian cancer malignant mesothelioma psoriasis osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.