Annotations: 5JCY

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DIL	e5jcyA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: DIL	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01843	DIL domain (DIL)	DIL domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Protein spire homolog 2	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding actin binding	cellular response to stimulus regulation of cellular process response to stimulus regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress cellular response to stimulus regulation of cellular process response to stimulus regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA repair double-strand break repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process positive regulation of double-strand break repair nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus DNA damage response metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process establishment of organelle localization cellular localization sexual reproduction reproductive process meiotic cell cycle microtubule cytoskeleton organization establishment of meiotic spindle localization spindle localization meiotic cell cycle process establishment of localization cellular component organization localization organelle organization establishment of spindle localization organelle localization establishment of localization in cell microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process actin cytoskeleton organization formin-nucleated actin cable assembly actin filament organization cellular component biogenesis parallel actin filament bundle assembly cellular component assembly actin filament bundle organization formin-nucleated actin cable organization actin filament-based process actin filament bundle assembly supramolecular fiber organization membrane organization cytoskeleton-dependent cytokinesis cytokinesis cleavage furrow formation cytokinetic process membrane invagination cell division plasma membrane invagination organelle fission multicellular organismal reproductive process female gamete generation meiotic cytokinesis gamete generation nuclear division female meiotic nuclear division polar body extrusion after meiotic divisions meiotic nuclear division transport intracellular transport actin nucleation establishment of protein localization nitrogen compound transport protein transport macromolecule localization intracellular protein localization actin filament network formation vesicle-mediated transport Golgi vesicle transport	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane cell periphery cell cortex cytoskeleton membraneless organelle intracellular membraneless organelle cytosol cell division site cleavage furrow plasma membrane plasma membrane region
A	Unconventional myosin-Va	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding RNA binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding RNA binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity microfilament motor activity macromolecular conformation isomerase activity	localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport establishment of protein localization nitrogen compound transport protein transport macromolecule localization intracellular protein localization protein localization to cell periphery cellular localization localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport establishment of protein localization nitrogen compound transport protein transport macromolecule localization intracellular protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane localization within membrane protein localization to membrane vesicle localization establishment of organelle localization establishment of melanosome localization establishment of vesicle localization cellular pigmentation pigment granule transport establishment of pigment granule localization pigmentation pigment granule localization organelle localization establishment of localization in cell melanosome transport melanosome localization cellular response to stimulus cellular response to nitrogen compound response to stimulus response to endogenous stimulus response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical response to insulin cellular response to insulin stimulus cellular response to hormone stimulus vesicle transport along actin filament vesicle cytoskeletal trafficking intracellular transport actin filament-based movement actin filament-based process cytoskeleton-dependent intracellular transport actin filament-based transport cellular component organization organelle organization actin cytoskeleton organization actin filament organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton cytosol filopodium tip cell projection actin-based cell projection filopodium plasma membrane bounded cell projection growth cone axon distal axon neuron projection site of polarized growth protein-containing complex myosin complex ruffle cell leading edge endomembrane system insulin-responsive compartment secretory granule secretory vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
B	IPR029901	Protein Spire	Family
B	IPR011019	KIND domain	Domain
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR001609	Myosin head, motor domain-like	Domain
A	IPR002710	Dilute domain	Domain
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR004009	Myosin, SH3 domain	Domain
A	IPR036103	Class V myosin, motor domain	Domain
A	IPR037988	Myosin 5a, cargo-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q8WWL2	vitiligo atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma neuroblastoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma squamous cell carcinoma X-linked mixed deafness with perilymphatic gusher cancer interstitial cystitis malignant glioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor vitiligo atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma neuroblastoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma squamous cell carcinoma X-linked mixed deafness with perilymphatic gusher cancer interstitial cystitis malignant glioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor ulcerative colitis cutaneous melanoma large cell medulloblastoma melanoma pancreatic intraductal papillary-mucinous carcinoma photosensitivity disease skin basal cell carcinoma
A	Pharos: Q9Y4I1	Griscelli syndrome type 1 neuroectodermal melanolysosomal disease Griscelli syndrome type 3 peripheral nervous system disease Liver Cirrhosis, Experimental peripheral neuropathy Griscelli syndrome ovarian cancer primitive neuroectodermal tumor acute myeloid leukemia ulcerative colitis breast cancer glioblastoma interstitial cystitis malignant mesothelioma Griscelli syndrome type 1 neuroectodermal melanolysosomal disease Griscelli syndrome type 3 peripheral nervous system disease Liver Cirrhosis, Experimental peripheral neuropathy Griscelli syndrome ovarian cancer primitive neuroectodermal tumor acute myeloid leukemia ulcerative colitis breast cancer glioblastoma interstitial cystitis malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma psoriasis astrocytic tumor diabetes mellitus IgA glomerulonephritis invasive ductal breast carcinoma malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor gastric carcinoma intellectual disability large cell medulloblastoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.