5QSV | pdb_00005qsv

PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434783

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B], D	PF21581	Stromalin conservative domain (SCD)	Stromalin conservative domain	-	Repeat
A [auth C], B [auth A], C [auth B], D	PF08514	STAG domain (STAG)	STAG domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B], D	Cohesin subunit SA-1	chromatin binding binding	cellular process cell division microtubule cytoskeleton organization membraneless organelle assembly mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cellular process cell division microtubule cytoskeleton organization membraneless organelle assembly mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based process cytoskeleton organization sister chromatid cohesion mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen nuclear lumen membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen nuclear lumen nuclear matrix membraneless organelle intracellular membraneless organelle chromosome cytoplasm cytosol chromosome, centromeric region chromosomal region protein-containing complex cohesin complex mitotic spindle spindle cytoskeleton mitotic spindle pole spindle pole microtubule cytoskeleton mitotic cohesin complex nuclear body nucleoplasm chromatin

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B], D	IPR039662	Cohesin subunit Scc3/SA	Family
A [auth C], B [auth A], C [auth B], D	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR056396	Cohesin subunit SCC3/SA, HEAT-repeats domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR020839	Stromalin conservative domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR013721	STAG	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B [auth A], C [auth B], D	Pharos: Q8WVM7	intellectual disability rheumatoid arthritis non-alcoholic fatty liver disease ovarian cancer primitive neuroectodermal tumor adenoma dental caries Epileptic encephalopathy malignant ependymoma microcephaly oligodendroglioma Pick disease astrocytic tumor diabetes mellitus glioblastoma intellectual disability rheumatoid arthritis non-alcoholic fatty liver disease ovarian cancer primitive neuroectodermal tumor adenoma dental caries Epileptic encephalopathy malignant ependymoma microcephaly oligodendroglioma Pick disease astrocytic tumor diabetes mellitus glioblastoma intellectual disability, autosomal dominant 47 malignant glioma myocardial infarction osteosarcoma pilocytic astrocytoma autism spectrum disorder endogenous depression heart disease large cell medulloblastoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.