5U77 | pdb_00005u77

Crystal structure of ORP8 PH domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8041204	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e5u77A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Oxysterol-binding protein-related protein 8	sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding lipid transporter activity transporter activity phospholipid transporter activity phospholipid transfer activity lipid transfer activity phosphatidylserine transfer activity phospholipid binding sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding lipid transporter activity transporter activity phospholipid transporter activity phospholipid transfer activity lipid transfer activity phosphatidylserine transfer activity phospholipid binding phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol binding modified amino acid binding ion binding anion binding phosphatidylserine binding	phosphatidylserine metabolic process phosphatidylserine acyl-chain remodeling glycerophospholipid metabolic process modified amino acid metabolic process primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process localization phosphatidylserine metabolic process phosphatidylserine acyl-chain remodeling glycerophospholipid metabolic process modified amino acid metabolic process primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process localization transport macromolecule localization phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport chemical homeostasis homeostatic process triglyceride homeostasis acylglycerol homeostasis lipid homeostasis protein localization to nuclear pore protein localization to organelle protein localization to nucleus intracellular protein localization protein localization to nuclear envelope cellular response to stimulus positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion developmental process fat cell differentiation cellular developmental process cell differentiation regulation of localization hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transport transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane cell cortex cortical endoplasmic reticulum cell periphery endoplasmic reticulum tubular network

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR018494	Oxysterol-binding protein, conserved site	Conserved Site
A	IPR037239	Oxysterol-binding protein superfamily	Homologous Superfamily
A	IPR000648	Oxysterol-binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BZF1	Weight Gain amyotrophic lateral sclerosis dermatomyositis Emery-Dreifuss muscular dystrophy large cell medulloblastoma ovarian cancer rheumatoid arthritis ulcerative colitis atypical teratoid rhabdoid tumor diabetes mellitus facioscapulohumeral muscular dystrophy malignant pancreatic neoplasm pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma Crohn disease Weight Gain amyotrophic lateral sclerosis dermatomyositis Emery-Dreifuss muscular dystrophy large cell medulloblastoma ovarian cancer rheumatoid arthritis ulcerative colitis atypical teratoid rhabdoid tumor diabetes mellitus facioscapulohumeral muscular dystrophy malignant pancreatic neoplasm pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma Crohn disease Duchenne muscular dystrophy juvenile dermatomyositis myopathy psoriasis tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.