5UQY | pdb_00005uqy

Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Filo_glycop	e5uqyA1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
E	Filo_glycop	e5uqyE1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
I	Filo_glycop	e5uqyI1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
M	Filo_glycop	e5uqyM1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
D	C1-set_1	e5uqyD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
D	V-set_12	e5uqyD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
H	C1-set_1	e5uqyH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
H	V-set_12	e5uqyH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
L	C1-set_1	e5uqyL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
L	V-set_12	e5uqyL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
P	C1-set_1	e5uqyP1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
P	V-set_12	e5uqyP2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
B	Ebola-like_HR1-HR2	e5uqyB1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
F	Ebola-like_HR1-HR2	e5uqyF1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
J	Ebola-like_HR1-HR2	e5uqyJ1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
N	Ebola-like_HR1-HR2	e5uqyN1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
C	C1-set_4	e5uqyC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
C	V-set	e5uqyC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
G	C1-set_4	e5uqyG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
G	V-set	e5uqyG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
K	C1-set_4	e5uqyK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
K	V-set	e5uqyK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
O	C1-set_4	e5uqyO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
O	V-set	e5uqyO2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
L	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
P	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
K	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
O	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
D, H, L, P	Fab MR78	VH-CH1	Homo sapiens (human)	IGHV4-3901, IGHV4-3907, IGHJ604, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG111	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202532-0)
C, G, K, O	Fab MR78	L-KAPPA	Homo sapiens (human)	IGKV1-3301, IGKV1D-3301, IGKJ301, IGKC01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202532-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
D, H, L, P	Heavy Chain	IGHV4	-	envelope glycoprotein gp1, envelope glycoprotein gp1 \| envelope glycoprotein gp2	SAbDab (2025-08-22)
C, G, K, O	Light Chain	IGKV1	Kappa	envelope glycoprotein gp1, envelope glycoprotein gp1 \| envelope glycoprotein gp2	SAbDab (2025-08-22)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, F, J, N	PF22307	Envelope glycoprotein GP2-like, HR1-HR2 (Ebola-like_HR1-HR2)	Envelope glycoprotein GP2-like, HR1-HR2	This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel ...	This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel orientation). This domain may have been acquired via horizontal transfer from retroviruses.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E, I, M	ENVELOPE GLYCOPROTEIN GP1	-	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host	virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane other organism part virion membrane
D, H, L, P	MR78 Fab heavy chain	-	-	-
B, F, J, N	ENVELOPE GLYCOPROTEIN GP2	-	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host	virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane other organism part virion membrane
C, G, K, O	MR78 Fab light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E, I, M	IPR018154	TLV/ENV coat polyprotein	Family
A, E, I, M	IPR014625	Filoviruses glycoprotein	Family
A, E, I, M	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
A, E, I, M	IPR054584	Envelope glycoprotein GP2-like, HR1-HR2	Domain
B, F, J, N	IPR018154	TLV/ENV coat polyprotein	Family
B, F, J, N	IPR014625	Filoviruses glycoprotein	Family
B, F, J, N	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
B, F, J, N	IPR054584	Envelope glycoprotein GP2-like, HR1-HR2	Domain