5XJB | pdb_00005xjb

The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-BeFx

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	P-loop motor domain	8035621	3002036	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	P-loop motor domain	8035621	3002036	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Kinesin	e5xjbA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)
B	Kinesin	e5xjbB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Kinesin-like protein KIF2C	microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule plus-end binding microtubule binding protein binding tubulin binding	mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment cellular component organization localization chromosome localization organelle localization mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment cellular component organization localization chromosome localization organelle localization mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation cellular process cell division cellular component disassembly protein-containing complex organization microtubule cytoskeleton organization protein-containing complex disassembly microtubule polymerization or depolymerization microtubule depolymerization microtubule-based process supramolecular fiber organization protein depolymerization cytoskeleton organization microtubule-based movement regulation of chromosome segregation regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation regulation of cell cycle regulation of localization cellular localization protein localization to synapse regulation of protein localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane intracellular protein localization regulation of biological quality regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels regulation of cellular localization macromolecule localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse cell junction organization postsynapse organization postsynaptic cytoskeleton organization synapse organization establishment or maintenance of microtubule cytoskeleton polarity establishment or maintenance of cytoskeleton polarity establishment or maintenance of cell polarity	polymeric cytoskeletal fiber intracellular anatomical structure microtubule end intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule plus-end polymeric cytoskeletal fiber intracellular anatomical structure microtubule end intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule plus-end microtubule cytoskeleton chromosome, centromeric region chromosome chromosomal region presynapse synapse cell junction cytoplasm glutamatergic synapse kinetochore condensed chromosome, centromeric region condensed chromosome postsynapse membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001752	Kinesin motor domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR027640	Kinesin-like protein	Family
A, B	IPR054473	Kinesin-like protein KIF2A-like, N-terminal	Domain
A, B	IPR019821	Kinesin motor domain, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.