7D5V | pdb_00007d5v

Structure of the C646A mutant of peptidylarginine deiminase type III (PAD3)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7d5va2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Peptidylarginine deiminase Pad4, middle domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d7d5va1	All beta proteins	Cupredoxin-like	Cupredoxins	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d7d5va3	Alpha and beta proteins (a+b)	Pentein, beta/alpha-propeller	Pentein	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d7d5vb2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Peptidylarginine deiminase Pad4, middle domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d7d5vb1	All beta proteins	Cupredoxin-like	Cupredoxins	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d7d5vb3	Alpha and beta proteins (a+b)	Pentein, beta/alpha-propeller	Pentein	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAD_M	e7d5vA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PAD_M	ECOD (1.6)
A	PAD_N	e7d5vA2	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: PAD_N	ECOD (1.6)
A	PAD,PAD_M	e7d5vA3	A: a+b duplicates or obligate multimers	X: Pentein (From Topology)	H: Pentein (From Topology)	T: Pentein	F: PAD,PAD_M	ECOD (1.6)
B	PAD_M	e7d5vB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PAD_M	ECOD (1.6)
B	PAD_N	e7d5vB3	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: PAD_N	ECOD (1.6)
B	PAD,PAD_M	e7d5vB2	A: a+b duplicates or obligate multimers	X: Pentein (From Topology)	H: Pentein (From Topology)	T: Pentein	F: PAD,PAD_M	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08527	Protein-arginine deiminase (PAD) middle domain (PAD_M)	Protein-arginine deiminase (PAD) middle domain	This family represents the central non-catalytic domain of protein-arginine deiminase. This domain has an immunoglobulin-like fold.	Domain
A, B	PF03068	Protein-arginine deiminase (PAD) (PAD)	Protein-arginine deiminase (PAD)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein-arginine deiminase type-3	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines hydrolase activity protein-arginine deiminase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds identical protein binding protein binding	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038685	PAD, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR013530	Protein-arginine deiminase, C-terminal	Domain
A, B	IPR013732	Protein-arginine deiminase (PAD), N-terminal	Domain
A, B	IPR036556	Protein-arginine deiminase, central domain superfamily	Homologous Superfamily
A, B	IPR013733	Protein-arginine deiminase (PAD), central domain	Domain
A, B	IPR008972	Cupredoxin	Homologous Superfamily
A, B	IPR004303	Protein-arginine deiminase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9ULW8	uncombable hair syndrome uncombable hair syndrome 1 interstitial cystitis Malignant neoplasm of breast rheumatoid arthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.