7FID | pdb_00007fid

Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1)

External Resource: Annotation

Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	2.30.130.40	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (utative)
A [auth B]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
A [auth B]	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
A [auth B]	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (utative)
B [auth C]	2.30.130.40	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (utative)
B [auth C]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
B [auth C]	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
B [auth C]	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (utative)
C [auth D]	2.30.130.40	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (utative)
C [auth D]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
C [auth D]	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
C [auth D]	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (utative)
D [auth E]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
D [auth E]	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
D [auth E]	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (utative)
E [auth F]	2.30.130.40	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (utative)
E [auth F]	1.20.5.5270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
E [auth F]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
E [auth F]	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
E [auth F]	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (utative)
F [auth A]	2.30.130.40	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (utative)
F [auth A]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
F [auth A]	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
F [auth A]	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (utative)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	Lon protease	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity ATP-dependent peptidase activity sequence-specific DNA binding DNA binding nucleic acid binding cation binding metal ion binding identical protein binding protein binding	cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus cellular process response to temperature stimulus catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus cellular process response to temperature stimulus catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process protein quality control for misfolded or incompletely synthesized proteins	cellular anatomical structure intracellular anatomical structure cytoplasm
G [auth S]	unknown endogenous substrate	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR027543	Lon protease, bacterial	Family
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR015947	PUA-like superfamily	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR046336	Lon protease, N-terminal domain superfamily	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR003111	Lon protease, N-terminal domain	Domain
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR004815	Lon protease, bacterial/eukaryotic-type	Family
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR054594	Lon protease, AAA+ ATPase lid domain	Domain
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR003593	AAA+ ATPase domain	Domain
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR008269	Peptidase S16, Lon proteolytic domain	Domain
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR027065	Lon protease	Family
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR008268	Peptidase S16, active site	Active Site
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR003959	ATPase, AAA-type, core	Domain
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], A [auth B], B [auth C], C [auth D], D [auth E], E [auth F], F [auth A]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily