7G4J | pdb_00007g4j

Crystal Structure of rat Autotaxin in complex with 4-[rac-(E)-3-oxo-3-[rac-(3aR,8aS)-2-(1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]prop-1-enyl]benzonitrile, i.e. SMILES C1C[C@@H]2[C@H](CCN1C(=O)/C=C/c1ccc(cc1)C#N)CN(C2)C(=O)c1ccc2c(c1)N=NN2 with IC50=0.193037 microM

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01033	Somatomedin B domain (Somatomedin_B)	Somatomedin B domain	-	Family
A	PF01223	DNA/RNA non-specific endonuclease (Endonuclease_NS)	DNA/RNA non-specific endonuclease		Domain
A	PF01663	Type I phosphodiesterase / nucleotide pyrophosphatase (Phosphodiest)	Type I phosphodiesterase / nucleotide pyrophosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding nucleic acid binding phosphoric ester hydrolase activity phospholipase D activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity hydrolase activity catalytic activity phospholipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding nucleic acid binding phosphoric ester hydrolase activity phospholipase D activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity cargo receptor activity scavenger receptor activity lysophospholipase activity phosphatidylcholine lysophospholipase activity carboxylic ester hydrolase activity nuclease activity phosphodiesterase I activity catalytic activity, acting on a nucleic acid exonuclease activity polysaccharide binding carbohydrate binding transition metal ion binding zinc ion binding alkylglycerophosphoethanolamine phosphodiesterase activity	phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process primary metabolic process phosphorus metabolic process lipid metabolic process ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process response to stimulus phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process primary metabolic process phosphorus metabolic process lipid metabolic process ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process response to stimulus immune response immune system process lipid catabolic process catabolic process phospholipid catabolic process glycerophospholipid metabolic process glycerolipid catabolic process organophosphate catabolic process phosphatidylcholine catabolic process phosphatidylcholine metabolic process glycerolipid metabolic process glycerophospholipid catabolic process response to polycyclic arene response to chemical positive regulation of substrate adhesion-dependent cell spreading regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion biological regulation positive regulation of biological process cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading positive regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cell chemotaxis cellular response to stimulus chemotaxis response to external stimulus cellular response to chemical stimulus taxis negative regulation of biological process negative regulation of cell-matrix adhesion negative regulation of cell adhesion negative regulation of cellular process negative regulation of cell-substrate adhesion sphingolipid catabolic process membrane lipid metabolic process sphingolipid metabolic process membrane lipid catabolic process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of cell morphogenesis positive regulation of developmental process cell projection morphogenesis regulation of lamellipodium organization anatomical structure development regulation of lamellipodium morphogenesis positive regulation of cell projection organization regulation of anatomical structure morphogenesis developmental process plasma membrane bounded cell projection organization positive regulation of lamellipodium morphogenesis regulation of cell projection organization positive regulation of lamellipodium organization anatomical structure morphogenesis lamellipodium organization lamellipodium morphogenesis regulation of plasma membrane bounded cell projection organization response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to lipid response to estradiol cellular response to estradiol stimulus multicellular organismal process positive regulation of nervous system development cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis positive regulation of gliogenesis regulation of cell development regulation of nervous system development multicellular organism development neurogenesis gliogenesis positive regulation of cell differentiation cell differentiation regulation of multicellular organismal process positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation system development regulation of multicellular organismal development positive regulation of cell development regulation of glial cell differentiation nervous system development positive regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation positive regulation of multicellular organismal process regulation of oligodendrocyte differentiation cellular response to metal ion response to metal ion cellular response to cadmium ion response to cadmium ion positive regulation of locomotion positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility epithelial cell migration regulation of epithelial cell migration epithelium migration	cellular anatomical structure membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR044929	DNA/RNA non-specific endonuclease superfamily	Homologous Superfamily
A	IPR020821	ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain	Domain
A	IPR001212	Somatomedin B domain	Domain
A	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily
A	IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase	Family
A	IPR020436	Somatomedin B domain, chordata	Domain
A	IPR044925	His-Me finger superfamily	Homologous Superfamily
A	IPR036024	Somatomedin B-like domain superfamily	Homologous Superfamily
A	IPR001604	DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.