7LEO | pdb_00007leo

C1B domain of Protein kinase C in complex with diacylglycerol-lactone (AJH-836) and 1,2-diheptanoyl-sn-glycero-3-phosphocholine

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1_1	e7leoA1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: Cysteine-rich domain	F: C1_1	ECOD (1.6)
B [auth D]	C1_1	e7leoD1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: Cysteine-rich domain	F: C1_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D]	PF00130	Phorbol esters/diacylglycerol binding domain (C1 domain) (C1_1)	Phorbol esters/diacylglycerol binding domain (C1 domain)	This domain is also known as the Protein kinase C conserved region 1 (C1) domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D]	Protein kinase C delta type	protein binding binding insulin receptor substrate binding protein serine/threonine kinase activity diacylglycerol-dependent serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity diacylglycerol-dependent, calcium-independent serine/threonine kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity protein binding binding insulin receptor substrate binding protein serine/threonine kinase activity diacylglycerol-dependent serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity diacylglycerol-dependent, calcium-independent serine/threonine kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding TIR domain binding protein domain specific binding calcium,diacylglycerol-dependent serine/threonine kinase activity calcium-dependent protein serine/threonine kinase activity protein serine kinase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase binding enzyme binding protein kinase binding cation binding transition metal ion binding zinc ion binding metal ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus regulation of biological process regulation of cellular process reactive oxygen species metabolic process biological regulation positive regulation of biological process regulation of superoxide metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus regulation of biological process regulation of cellular process reactive oxygen species metabolic process biological regulation positive regulation of biological process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of metabolic process regulation of reactive oxygen species metabolic process positive regulation of cellular process phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorylation regulation of phosphorus metabolic process phosphorus metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cell communication positive regulation of response to stimulus signal transduction regulation of signaling positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation multicellular organismal process regulation of body fluid levels negative regulation of biological process regulation of cell activation negative regulation of cell adhesion negative regulation of platelet activation regulation of coagulation regulation of biological quality response to wounding negative regulation of homotypic cell-cell adhesion negative regulation of wound healing negative regulation of blood coagulation response to external stimulus blood coagulation negative regulation of hemostasis regulation of platelet activation negative regulation of response to external stimulus negative regulation of cell-cell adhesion regulation of wound healing negative regulation of multicellular organismal process platelet activation regulation of response to external stimulus homotypic cell-cell adhesion regulation of response to wounding cell adhesion cell-cell adhesion regulation of response to stress negative regulation of cellular process coagulation regulation of cell-cell adhesion regulation of multicellular organismal process regulation of hemostasis wound healing negative regulation of response to stimulus regulation of homotypic cell-cell adhesion regulation of cell adhesion regulation of blood coagulation hemostasis cell activation negative regulation of platelet aggregation negative regulation of response to wounding platelet aggregation negative regulation of cell activation regulation of platelet aggregation negative regulation of coagulation biological process involved in interspecies interaction between organisms response to other organism defense response response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus cellular senescence protein localization regulation of localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization establishment of protein localization to organelle positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport response to oxidative stress cellular response to chemical stimulus cellular response to oxidative stress cellular response to chemical stress sphingolipid catabolic process regulation of amide metabolic process catabolic process sphingomyelin catabolic process phospholipid catabolic process regulation of lipid metabolic process organophosphate catabolic process positive regulation of phosphate metabolic process regulation of sphingomyelin catabolic process positive regulation of phospholipid catabolic process regulation of primary metabolic process phospholipid metabolic process positive regulation of lipid catabolic process positive regulation of lipid metabolic process amide metabolic process sphingomyelin metabolic process membrane lipid metabolic process regulation of phospholipid catabolic process regulation of membrane lipid metabolic process lipid catabolic process positive regulation of phosphorus metabolic process positive regulation of sphingomyelin catabolic process regulation of phospholipid metabolic process primary metabolic process sphingolipid metabolic process regulation of catabolic process regulation of lipid catabolic process membrane lipid catabolic process positive regulation of phospholipid metabolic process positive regulation of catabolic process organophosphate metabolic process positive regulation of amide metabolic process lipid metabolic process cellular response to nitrogen compound negative regulation of signaling response to peptide hormone insulin receptor signaling pathway regulation of cellular response to insulin stimulus negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound negative regulation of signal transduction cellular response to oxygen-containing compound negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway response to insulin cellular response to insulin stimulus filopodium assembly regulation of cellular component organization cell projection organization negative regulation of filopodium assembly regulation of filopodium assembly plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis negative regulation of plasma membrane bounded cell projection assembly cellular component assembly cellular component organization or biogenesis negative regulation of cell projection organization plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization macromolecule modification protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process cell chemotaxis chemotaxis taxis cell migration cell motility locomotion response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus protein phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification regulation of glial cell apoptotic process negative regulation of programmed cell death negative regulation of glial cell apoptotic process glial cell apoptotic process negative regulation of apoptotic process response to hydrogen peroxide response to reactive oxygen species response to acid chemical response to amino acid response to hydroperoxide cellular response to hydroperoxide regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization neutrophil activation myeloid leukocyte activation granulocyte activation leukocyte activation sphingolipid biosynthetic process lipid biosynthetic process regulation of sphingolipid biosynthetic process regulation of ceramide biosynthetic process regulation of biosynthetic process ceramide metabolic process amide biosynthetic process regulation of macromolecule metabolic process macromolecule biosynthetic process biosynthetic process ceramide biosynthetic process regulation of macromolecule biosynthetic process regulation of lipid biosynthetic process membrane lipid biosynthetic process organic acid transmembrane transport import into cell organic anion transport carboxylic acid transport carboxylic acid transmembrane transport aspartate transmembrane transport import across plasma membrane amino acid transmembrane transport C4-dicarboxylate transport D-amino acid transport organic acid transport amino acid transport transmembrane transport D-aspartate transmembrane transport D-aspartate import across plasma membrane dicarboxylic acid transport amino acid import across plasma membrane termination of signal transduction response to hexose response to monosaccharide response to carbohydrate response to glucose glycolipid metabolic process carbohydrate derivative metabolic process regulation of glucosylceramide catabolic process ceramide catabolic process glycosylceramide metabolic process carbohydrate derivative catabolic process positive regulation of glucosylceramide catabolic process glycosphingolipid catabolic process glycosphingolipid metabolic process liposaccharide metabolic process glucosylceramide metabolic process glycosylceramide catabolic process glycolipid catabolic process glucosylceramide catabolic process regulation of cellular component size regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization protein-containing complex organization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization actin filament organization negative regulation of protein-containing complex assembly negative regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of supramolecular fiber organization supramolecular fiber organization regulation of anatomical structure size response to alcohol response to ethanol cell population proliferation B cell activation B cell proliferation lymphocyte activation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation cellular response to hydrogen peroxide cellular response to reactive oxygen species negative regulation of intracellular signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of MAPK cascade MAPK cascade negative regulation of MAPK cascade positive regulation of MAPK cascade positive regulation of intracellular signal transduction response to mechanical stimulus response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV collagen metabolic process hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transmembrane transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport response to angiotensin cellular response to angiotensin positive regulation of ceramide biosynthetic process positive regulation of sphingolipid biosynthetic process positive regulation of biosynthetic process positive regulation of lipid biosynthetic process	cellular anatomical structure membrane cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle cellular anatomical structure membrane cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix endosome intracellular vesicle lytic vacuole vacuole endomembrane system endolysosome cytoplasmic vesicle vesicle lysosome cell periphery plasma membrane endoplasmic reticulum cytosolic region postsynapse synapse postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D]	IPR020454	Diacylglycerol/phorbol-ester binding	Domain
A, B [auth D]	IPR014376	Protein kinase C, delta/epsilon/eta/theta types	Family
A, B [auth D]	IPR000719	Protein kinase domain	Domain
A, B [auth D]	IPR017892	Protein kinase, C-terminal	Domain
A, B [auth D]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B [auth D]	IPR000008	C2 domain	Domain
A, B [auth D]	IPR000961	AGC-kinase, C-terminal	Domain
A, B [auth D]	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A, B [auth D]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B [auth D]	IPR035892	C2 domain superfamily	Homologous Superfamily
A, B [auth D]	IPR027436	Protein kinase C, delta	Family
A, B [auth D]	IPR046349	C1-like domain superfamily	Homologous Superfamily
A, B [auth D]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth D]	OPM				C1 domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.