Structure of the cGAS-like receptor human MB21D2
Domain Annotation: ECOD Classification ECOD Database Homepage
| Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
|---|---|---|---|---|---|---|---|---|
| B | Mab-21_C | e7lt1B1 | A: alpha arrays | X: HhH/H2TH | H: SAM/DNA-glycosylase | T: PAP/OAS1 substrate-binding domain | F: Mab-21_C | ECOD (1.6) |
| B | Mab-21_N | e7lt1B2 | A: a+b three layers | X: Nucleotidyltransferase-like | H: Nucleotidyltransferase (From Topology) | T: Nucleotidyltransferase | F: Mab-21_N | ECOD (1.6) |
| A | Mab-21_C | e7lt1A1 | A: alpha arrays | X: HhH/H2TH | H: SAM/DNA-glycosylase | T: PAP/OAS1 substrate-binding domain | F: Mab-21_C | ECOD (1.6) |
| A | Mab-21_N | e7lt1A2 | A: a+b three layers | X: Nucleotidyltransferase-like | H: Nucleotidyltransferase (From Topology) | T: Nucleotidyltransferase | F: Mab-21_N | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
| Chains | Accession | Name | Description | Comments | Source |
|---|---|---|---|---|---|
| PF03281 | Mab-21 protein nucleotidyltransferase domain (Mab-21) | Mab-21 protein nucleotidyltransferase domain | This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development [2-3]. | Domain | |
| PF20266 | Mab-21 protein HhH/H2TH-like domain (Mab-21_C) | Mab-21 protein HhH/H2TH-like domain | This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development [2-3]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
| Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
|---|---|---|---|---|
| Protein MB21D2 | - | - |
InterPro: Protein Family Classification InterPro Database Homepage
| Chains | Accession | Name | Type |
|---|---|---|---|
| IPR024810 | MAB21L/Cyclic GMP-AMP synthase-like receptor | Family | |
| IPR046903 | Mab-21-like, nucleotidyltransferase domain | Domain | |
| IPR046906 | Mab-21-like, HhH/H2TH-like domain | Domain |
Pharos: Disease Associations Pharos Homepage Annotation
| Chains | Drug Target   | Associated Disease |
|---|---|---|
| :  Q8IYB1 |














