EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Spike_NTD | e7nd7A2 | A: beta sandwiches | X: jelly-roll | H: Concanavalin A-like | T: Concanavalin A-like lectins/glucanases | F: Spike_NTD | ECOD (1.6) |
A | Spike_rec_bind_1 | e7nd7A1 | A: beta complex topology | X: Beta domain of coronavirus spike glycoprotein (From Topology) | H: Beta domain of coronavirus spike glycoprotein (From Topology) | T: Beta domain of coronavirus spike glycoprotein | F: Spike_rec_bind_1 | ECOD (1.6) |
A | Spike_rec_bind | e7nd7A3 | A: a+b three layers | X: Coronavirus spike protein receptor-binding domain (From Homology) | H: Coronavirus spike protein receptor-binding domain | T: Beta-coronavirus spike protein receptor-binding domain | F: Spike_rec_bind | ECOD (1.6) |
A | Corona_S2 | e7nd7A4 | A: a+b complex topology | X: S2 subunit of coronavirus spike glycoprotein (From Topology) | H: S2 subunit of coronavirus spike glycoprotein (From Topology) | T: S2 subunit of coronavirus spike glycoprotein | F: Corona_S2 | ECOD (1.6) |
B | Spike_NTD | e7nd7B1 | A: beta sandwiches | X: jelly-roll | H: Concanavalin A-like | T: Concanavalin A-like lectins/glucanases | F: Spike_NTD | ECOD (1.6) |
B | Spike_rec_bind_1 | e7nd7B2 | A: beta complex topology | X: Beta domain of coronavirus spike glycoprotein (From Topology) | H: Beta domain of coronavirus spike glycoprotein (From Topology) | T: Beta domain of coronavirus spike glycoprotein | F: Spike_rec_bind_1 | ECOD (1.6) |
B | Spike_rec_bind | e7nd7B4 | A: a+b three layers | X: Coronavirus spike protein receptor-binding domain (From Homology) | H: Coronavirus spike protein receptor-binding domain | T: Beta-coronavirus spike protein receptor-binding domain | F: Spike_rec_bind | ECOD (1.6) |
B | Corona_S2 | e7nd7B3 | A: a+b complex topology | X: S2 subunit of coronavirus spike glycoprotein (From Topology) | H: S2 subunit of coronavirus spike glycoprotein (From Topology) | T: S2 subunit of coronavirus spike glycoprotein | F: Corona_S2 | ECOD (1.6) |
C | Spike_NTD | e7nd7C3 | A: beta sandwiches | X: jelly-roll | H: Concanavalin A-like | T: Concanavalin A-like lectins/glucanases | F: Spike_NTD | ECOD (1.6) |
C | Spike_rec_bind_1 | e7nd7C1 | A: beta complex topology | X: Beta domain of coronavirus spike glycoprotein (From Topology) | H: Beta domain of coronavirus spike glycoprotein (From Topology) | T: Beta domain of coronavirus spike glycoprotein | F: Spike_rec_bind_1 | ECOD (1.6) |
C | Spike_rec_bind | e7nd7C2 | A: a+b three layers | X: Coronavirus spike protein receptor-binding domain (From Homology) | H: Coronavirus spike protein receptor-binding domain | T: Beta-coronavirus spike protein receptor-binding domain | F: Spike_rec_bind | ECOD (1.6) |
C | Corona_S2 | e7nd7C4 | A: a+b complex topology | X: S2 subunit of coronavirus spike glycoprotein (From Topology) | H: S2 subunit of coronavirus spike glycoprotein (From Topology) | T: S2 subunit of coronavirus spike glycoprotein | F: Corona_S2 | ECOD (1.6) |
D [auth H] | V-set_8 | e7nd7H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
F | V-set_8 | e7nd7F1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
H [auth J] | V-set_8 | e7nd7J1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
E [auth L] | V-set_3 | e7nd7L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
G | V-set_3 | e7nd7G1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
I [auth K] | V-set_3 | e7nd7K1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.120.960 | Mainly Beta | Sandwich | Jelly Rolls | Spike glycoprotein, N-terminal domain | CATH (utative) |
B | 2.60.120.960 | Mainly Beta | Sandwich | Jelly Rolls | Spike glycoprotein, N-terminal domain | CATH (utative) |
C | 2.60.120.960 | Mainly Beta | Sandwich | Jelly Rolls | Spike glycoprotein, N-terminal domain | CATH (utative) |
D [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
F | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
H [auth J] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
E [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
G | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
I [auth K] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
D [auth H], F, H [auth J] | Heavy Chain | IGHV1 | - | spike glycoprotein | SAbDab (2025-07-04) |
E [auth L], G, I [auth K] | Light Chain | IGLV2 | Lambda | spike glycoprotein | SAbDab (2025-07-04) |