7P6R | pdb_00007p6r

Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2	binding antigen binding	multicellular organismal process response to stimulus transport immune response antigen transcytosis by M cells in mucosal-associated lymphoid tissue establishment of localization antigen sampling in mucosal-associated lymphoid tissue vesicle-mediated transport localization antigen sampling by M cells in mucosal-associated lymphoid tissue immune system process cellular process transcytosis mucosal immune response multicellular organismal process response to stimulus transport immune response antigen transcytosis by M cells in mucosal-associated lymphoid tissue establishment of localization antigen sampling in mucosal-associated lymphoid tissue vesicle-mediated transport localization antigen sampling by M cells in mucosal-associated lymphoid tissue immune system process cellular process transcytosis mucosal immune response organ or tissue specific immune response leukocyte migration myeloid leukocyte migration cell migration neutrophil migration cell motility granulocyte migration biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle extracellular region extracellular exosome extracellular vesicle extracellular organelle extracellular space extracellular membrane-bounded organelle zymogen granule zymogen granule membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane secretory granule secretory vesicle organelle membrane secretory granule membrane membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017977	Zona pellucida domain, conserved site	Conserved Site
A, B	IPR042235	Zona pellucida, ZP-C domain	Homologous Superfamily
A, B	IPR055356	ZP-N domain	Domain
A, B	IPR055355	ZP-C domain	Domain
A, B	IPR048290	Zona pellucida domain, chordate-type	Domain
A, B	IPR001507	Zona pellucida domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P55259	Body Weight Ebola hemorrhagic fever Lassa fever malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic kidney disease head and neck cancer lung carcinoma nephrolithiasis pancreatic intraductal papillary-mucinous carcinoma type 2 diabetes mellitus chronic obstructive pulmonary disease hypertensive disorder malignant colon neoplasm Body Weight Ebola hemorrhagic fever Lassa fever malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic kidney disease head and neck cancer lung carcinoma nephrolithiasis pancreatic intraductal papillary-mucinous carcinoma type 2 diabetes mellitus chronic obstructive pulmonary disease hypertensive disorder malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.