Annotations: 7W7C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ABC_tran	e7w7cA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)
B	F_UNCLASSIFIED	e7w7cB1	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type II ABC exporter transmembrane domain-related	T: MacB transmembrane domain	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain
B	PF12704	MacB-like periplasmic core domain (MacB_PCD)	MacB-like periplasmic core domain	This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein [1]. Some structural similarity was found to the periplasmic domain of the AcrB multidrug eff ...	This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein [1]. Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter.	Domain
B	PF02687	FtsX-like permease C-terminal (FtsX)	FtsX-like permease C-terminal	This entry represents the C-terminal helices found in members of the ABC type 3 transporter family of permeases, including Cell division protein FtsX from Gram-negative and Gram-positive bacteria [1], Permease protein MacB [2], Lipoprotein-releasing ...	This entry represents the C-terminal helices found in members of the ABC type 3 transporter family of permeases, including Cell division protein FtsX from Gram-negative and Gram-positive bacteria [1], Permease protein MacB [2], Lipoprotein-releasing system transmembrane protein LolC (Swiss:P57382) which has been shown to transport lipids targeted to the outer membrane across the inner membrane [3]. This region contains three transmembrane helices.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Putative ABC transport system, ATP-binding protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity cation binding metal ion binding transporter activity transmembrane transporter activity	-	cell periphery cellular anatomical structure plasma membrane membrane
B	Putative ABC transport system integral membrane protein	cation binding ion binding binding metal ion binding small molecule binding	-	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR017871	ABC transporter-like, conserved site	Conserved Site
A	IPR017911	MacB-like, ATP-binding domain	Domain
A	IPR015854	ABC transporter, lipoprotein release, LolD-like	Family
A	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR003838	ABC3 transporter permease, C-terminal	Domain
B	IPR051125	ABC-4 integral membrane protein family, HrtB subfamily	Family
B	IPR025857	MacB-like periplasmic core domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
B	OPM	Transmembrane	Alpha-helical polytopic	ABC transporters	FtsX-like permease

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
B	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.