Annotations: 8E0D

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ras	e8e0dA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00025	ADP-ribosylation factor family (Arf)	ADP-ribosylation factor family	Pfam combines a number of different Prosite families together	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GTP-binding protein SAR1b	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding amino acid sensor activity molecular sensor activity molecular function regulator activity pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity cation binding metal ion binding	establishment of organelle localization vesicle budding from membrane cellular localization regulation of cellular component organization regulation of cellular process transport vesicle targeting, to, from or within Golgi vesicle-mediated transport vesicle targeting cellular component organization cellular component biogenesis vesicle organization localization regulation of protein-containing complex assembly cellular component assembly establishment of organelle localization vesicle budding from membrane cellular localization regulation of cellular component organization regulation of cellular process transport vesicle targeting, to, from or within Golgi vesicle-mediated transport vesicle targeting cellular component organization cellular component biogenesis vesicle organization localization regulation of protein-containing complex assembly cellular component assembly organelle localization establishment of localization in cell protein-containing complex assembly vesicle coating regulation of COPII vesicle coating cellular component organization or biogenesis vesicle targeting, rough ER to cis-Golgi membrane organization vesicle localization regulation of biological process protein-containing complex organization establishment of vesicle localization biological regulation intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport regulation of cellular component biogenesis establishment of localization regulation of organelle organization organelle organization cellular process COPII-coated vesicle budding COPII vesicle coating Golgi vesicle transport chemical homeostasis homeostatic process lipid homeostasis cellular response to stimulus TOR signaling regulation of signaling response to stimulus regulation of TOR signaling signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication regulation of TORC1 signaling signal transduction TORC1 signaling lipid export from cell macromolecule localization lipid localization export from cell lipid transport response to nutrient levels cellular response to leucine starvation cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to stress response to amino acid starvation response to starvation regulation of localization regulation of transport regulation of lipid transport regulation of lipid localization establishment of protein localization nitrogen compound transport protein transport lipoprotein transport intracellular protein localization lipoprotein localization intracellular protein transport negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling negative regulation of cellular process negative regulation of response to stimulus negative regulation of signal transduction vesicle cargo loading COPII-coated vesicle cargo loading antigen processing and presentation immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle Golgi stack organelle membrane protein-containing complex vesicle coat intracellular vesicle transport vesicle membrane membrane protein complex membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle ER to Golgi transport vesicle membrane coated vesicle vesicle transport vesicle coated membrane COPII vesicle coat cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum exit site vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR005225	Small GTP-binding domain	Domain
A	IPR006687	Small GTPase superfamily, SAR1-type	Family
A	IPR006689	Small GTPase superfamily, ARF/SAR type	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y6B6	chylomicron retention disease tuberculosis Ataxias, Hereditary breast carcinoma cystic fibrosis exocrine pancreatic carcinoma large cell medulloblastoma medulloblastoma plasma cell myeloma attention deficit hyperactivity disorder, inattentive type Duchenne muscular dystrophy hereditary spastic paraplegia lung adenocarcinoma ovarian cancer psoriasis chylomicron retention disease tuberculosis Ataxias, Hereditary breast carcinoma cystic fibrosis exocrine pancreatic carcinoma large cell medulloblastoma medulloblastoma plasma cell myeloma attention deficit hyperactivity disorder, inattentive type Duchenne muscular dystrophy hereditary spastic paraplegia lung adenocarcinoma ovarian cancer psoriasis atypical teratoid rhabdoid tumor cutaneous lupus erythematosus Emery-Dreifuss muscular dystrophy malignant pancreatic neoplasm pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.