8HX9 | pdb_00008hx9

Crystal structure of 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae with chorismate

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00425	chorismate binding enzyme (Chorismate_bind)	chorismate binding enzyme	This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.	Domain
A, B	PF00117	Glutamine amidotransferase class-I (GATase)	Glutamine amidotransferase class-I		Domain
A, B	PF04715	Anthranilate synthase component I, N terminal region (Anth_synt_I_N)	Anthranilate synthase component I, N terminal region	Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the cho ...	Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (Pfam:PF00425). This region is involved in feedback inhibition by tryptophan [1]. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	4-amino-4-deoxychorismate synthase	transferase activity, transferring nitrogenous groups transaminase activity transferase activity catalytic activity 4-amino-4-deoxychorismate synthase activity	benzene-containing compound metabolic process aromatic amino acid metabolic process monocarboxylic acid biosynthetic process aromatic amino acid family biosynthetic process oxoacid metabolic process small molecule biosynthetic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process amino acid biosynthetic process biosynthetic process 4-aminobenzoate biosynthetic process benzene-containing compound metabolic process aromatic amino acid metabolic process monocarboxylic acid biosynthetic process aromatic amino acid family biosynthetic process oxoacid metabolic process small molecule biosynthetic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process amino acid biosynthetic process biosynthetic process 4-aminobenzoate biosynthetic process para-aminobenzoic acid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process folic acid-containing compound biosynthetic process folic acid-containing compound metabolic process pteridine-containing compound biosynthetic process modified amino acid biosynthetic process modified amino acid metabolic process pteridine-containing compound metabolic process indole-containing compound metabolic process alpha-amino acid metabolic process biogenic amine biosynthetic process indole-containing compound biosynthetic process L-tryptophan metabolic process indolalkylamine metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process indolalkylamine biosynthetic process L-amino acid biosynthetic process L-amino acid metabolic process L-tryptophan biosynthetic process proteinogenic amino acid metabolic process amine metabolic process amine biosynthetic process proteinogenic amino acid biosynthetic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process biogenic amine metabolic process alpha-amino acid biosynthetic process antibiotic metabolic process antibiotic biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029062	Class I glutamine amidotransferase-like	Homologous Superfamily
A, B	IPR005802	Aminodeoxychorismate synthase, component I	Family
A, B	IPR019999	Anthranilate synthase component I-like	Family
A, B	IPR005801	ADC synthase	Homologous Superfamily
A, B	IPR006221	Anthranilate synthase/para-aminobenzoate synthase like domain	Domain
A, B	IPR017926	Glutamine amidotransferase	Domain
A, B	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain
A, B	IPR006805	Anthranilate synthase component I, N-terminal	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	OCS	Parent Component: CYS RESID: AA0556 PSI-MOD : L-cysteic acid (L-cysteine sulfonic acid) MOD:00460

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.