8Q6I | pdb_00008q6i

Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 1 C-terminal substitution)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth D]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
E [auth G]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ADP-ribosylation	8041372	3001208	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth D], C [auth E], D [auth F], E [auth G], F [auth H]	PF01376	Heat-labile enterotoxin beta chain (Enterotoxin_b)	Heat-labile enterotoxin beta chain		Domain
A	PF01375	Heat-labile enterotoxin alpha chain (Enterotoxin_a)	Heat-labile enterotoxin alpha chain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth D], C [auth E], D [auth F], E [auth G], F [auth H]	Cholera enterotoxin subunit B	binding galactose binding monosaccharide binding carbohydrate binding small molecule binding host cell surface binding toxin activity	cellular response to stimulus regulation of cellular process response to stimulus positive regulation of phosphorylation positive regulation of phosphate metabolic process cell communication regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process signal transduction protein modification process cellular response to stimulus regulation of cellular process response to stimulus positive regulation of phosphorylation positive regulation of phosphate metabolic process cell communication regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process signal transduction protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein regulation of biological process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process signaling regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process positive regulation of cellular process cell surface receptor signaling pathway regulation of tyrosine phosphorylation of STAT protein biological regulation regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process positive regulation of tyrosine phosphorylation of STAT protein cellular process regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane periplasmic space protein-containing complex catalytic complex extracellular region
A	Cholera enterotoxin subunit A	glycosyltransferase activity transferase activity catalytic activity binding galactose binding monosaccharide binding carbohydrate binding small molecule binding lipid binding nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups toxin activity	cellular response to stimulus regulation of cellular process response to stimulus positive regulation of phosphorylation positive regulation of phosphate metabolic process cell communication regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process signal transduction protein modification process cellular response to stimulus regulation of cellular process response to stimulus positive regulation of phosphorylation positive regulation of phosphate metabolic process cell communication regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process signal transduction protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein regulation of biological process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process signaling regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process positive regulation of cellular process cell surface receptor signaling pathway regulation of tyrosine phosphorylation of STAT protein biological regulation regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process positive regulation of tyrosine phosphorylation of STAT protein cellular process regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT	cellular anatomical structure periplasmic space protein-containing complex catalytic complex extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth D], C [auth E], D [auth F], E [auth G], F [auth H]	IPR001835	Heat-labile enterotoxin, B chain	Family
B [auth D], C [auth E], D [auth F], E [auth G], F [auth H]	IPR008992	Enterotoxin	Homologous Superfamily
A	IPR001144	Heat-labile enterotoxin, A chain	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	HIC	Parent Component: HIS RESID: AA0317 PSI-MOD : 1'-methyl-L-histidine MOD:00322

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.