8QFX | pdb_00008qfx

Human Angiotensin-1 converting enzyme N-domain in complex with the lactotripeptide IPP

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01401	Angiotensin-converting enzyme (Peptidase_M2)	Angiotensin-converting enzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Angiotensin-converting enzyme, soluble form	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding metallocarboxypeptidase activity exopeptidase activity metalloexopeptidase activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding metallocarboxypeptidase activity exopeptidase activity metalloexopeptidase activity carboxypeptidase activity endopeptidase activity calmodulin binding mitogen-activated protein kinase binding metallodipeptidase activity dipeptidase activity metalloendopeptidase activity ion binding anion binding chloride ion binding small molecule binding peptidyl-dipeptidase activity cytoskeletal protein binding actin binding signaling receptor binding bradykinin receptor binding G protein-coupled receptor binding serine-type exopeptidase activity serine hydrolase activity serine-type peptidase activity tripeptidyl-peptidase activity cation binding transition metal ion binding zinc ion binding metal ion binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development organic anion transport carboxylic acid transport secretion transport arachidonate transport lipid localization lipid transport establishment of localization organic acid transport localization arachidonate secretion monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport catabolic process metabolic process cellular process peptide metabolic process peptide catabolic process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure endocrine process regulation of renal output by angiotensin regulation of biological process regulation of cellular process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process regulation of angiotensin metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of tube diameter regulation of tube size regulation of system process regulation of blood circulation regulation of vasoconstriction vascular process in circulatory system regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to stimulus cellular response to nitrogen compound response to angiotensin response to stimulus signaling response to peptide hormone angiotensin-activated signaling pathway cellular response to angiotensin cell communication cellular response to endogenous stimulus response to hormone signal transduction cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical G protein-coupled receptor signaling pathway neuropeptide catabolic process substance P catabolic process amide metabolic process regulation of biosynthetic process gene expression macromolecule biosynthetic process post-transcriptional regulation of gene expression regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of cell motility regulation of smooth muscle cell migration smooth muscle cell migration muscle cell migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion regulation of cellular component organization negative regulation of cellular component organization gap junction assembly regulation of gap junction assembly negative regulation of biological process regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of cell junction assembly negative regulation of gap junction assembly cell junction organization cellular component assembly negative regulation of cell junction assembly cell junction assembly negative regulation of cellular process cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization cell population proliferation mononuclear cell proliferation leukocyte proliferation positive regulation of systemic arterial blood pressure positive regulation of blood pressure bradykinin catabolic process kidney development renal system development heart process regulation of heart contraction cardiac conduction regulation of heart rate by cardiac conduction heart contraction regulation of heart rate peptide hormone processing signaling receptor ligand precursor processing protein maturation proteolysis regulation of hormone levels regulation of systemic arterial blood pressure by circulatory renin-angiotensin hormone metabolic process regulation of angiotensin levels in blood protein processing angiotensin maturation amyloid-beta metabolic process regulation of stem cell proliferation cellular developmental process hemopoiesis cell development stem cell proliferation regulation of cell population proliferation cell differentiation hematopoietic stem cell proliferation regulation of hematopoietic stem cell proliferation neutrophil mediated immunity immune system process leukocyte mediated immunity myeloid leukocyte mediated immunity immune effector process stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation blood vessel remodeling tissue remodeling regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cell proliferation in bone marrow hormone catabolic process antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure lytic vacuole vacuole cytoplasm intracellular membrane-bounded organelle lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle
E, F, G, H	ILE-PRO-PRO	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001548	Peptidase M2, peptidyl-dipeptidase A	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P12821	hypertensive disorder Alzheimer disease severe acute respiratory syndrome myocardial infarction atrial fibrillation kidney failure coronary artery disease IgA glomerulonephritis cerebrovascular disorder Gaucher disease congestive heart failure meningococcal infection kidney disease glycogen storage disease V Diabetes Mellitus, Experimental hypertensive disorder Alzheimer disease severe acute respiratory syndrome myocardial infarction atrial fibrillation kidney failure coronary artery disease IgA glomerulonephritis cerebrovascular disorder Gaucher disease congestive heart failure meningococcal infection kidney disease glycogen storage disease V Diabetes Mellitus, Experimental cardiovascular disease intracerebral hemorrhage granular cell carcinoma male infertility non-alcoholic fatty liver disease brain ischemia chronic kidney disease prostate cancer renal tubular dysgenesis of genetic origin tubular adenocarcinoma drug allergy viral pneumonia chronic beryllium disease preeclampsia adenocarcinoma pulmonary hypertension coronary restenosis microvascular complications of diabetes, susceptibility to, 3 depressive disorder hypotensive disorder autoimmune disease bipolar disorder peripheral arterial disease drug psychosis pneumonia gastric neoplasm lung benign neoplasm renal tubular dysgenesis respiratory system disease heart disease cribriform carcinoma schizophrenia hepatocellular carcinoma angioedema dementia autism diabetic kidney disease thrombotic disease obesity disorder inherited disease susceptibility peripheral vascular disease essential hypertension familial atrial fibrillation lung disease major affective disorder 2 heart failure cribriform carcinoma of breast hereditary diffuse gastric adenocarcinoma aortic disease staphylococcus aureus infection hyperglycemia atherosclerosis diabetes mellitus non-small cell lung carcinoma inborn carbohydrate metabolic disorder inherited lipid metabolism disorder facioscapulohumeral muscular dystrophy gastric cancer lung adenocarcinoma chronic obstructive pulmonary disease adult acute respiratory distress syndrome major depressive disorder COVID-19 sarcoidosis anemia staphylococcal infection Hodgkins lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.