8S0N | pdb_00008s0n

Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07

External Resource: Annotation

SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B, C [auth D]	Heavy Chain	IGHV1	-	transmembrane protease serine 2	SAbDab (2025-09-12)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth C]	PF15494	Scavenger receptor cysteine-rich domain (SRCR_2)	Scavenger receptor cysteine-rich domain	SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth C]	Transmembrane protease serine 2	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	viral gene expression viral process viral translation primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein autoprocessing biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process viral gene expression viral process viral translation primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein autoprocessing biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of biological process biological process involved in interspecies interaction between organisms positive regulation of viral life cycle positive regulation of viral process biological regulation positive regulation of biological process viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process symbiont entry into host cell symbiont entry into host positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane intracellular anatomical structure cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
B, C [auth D]	nanobody A07	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth C]	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat	Repeat
A, D [auth C]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, D [auth C]	IPR001190	SRCR domain	Domain
A, D [auth C]	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, D [auth C]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A, D [auth C]	IPR036772	SRCR-like domain superfamily	Homologous Superfamily
A, D [auth C]	IPR001254	Serine proteases, trypsin domain	Domain
A, D [auth C]	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site	Conserved Site
A, D [auth C]	IPR036055	LDL receptor-like superfamily	Homologous Superfamily
A, D [auth C]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, D [auth C]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D [auth C]	Pharos: O15393	prostate cancer ovarian cancer psoriasis adult acute respiratory distress syndrome cutaneous melanoma gastric carcinoma interstitial cystitis lung cancer melanoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm prostate carcinoma severe acute respiratory syndrome breast cancer cystic fibrosis prostate cancer ovarian cancer psoriasis adult acute respiratory distress syndrome cutaneous melanoma gastric carcinoma interstitial cystitis lung cancer melanoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm prostate carcinoma severe acute respiratory syndrome breast cancer cystic fibrosis Gastro-esophageal reflux disease with esophagitis large cell medulloblastoma lung carcinoma Middle East respiratory syndrome osteosarcoma pneumonia COVID-19 Down syndrome influenza lung adenocarcinoma malignant glioma nasopharyngeal carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.