8SX1 | pdb_00008sx1

PARP4 catalytic domain

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00644	Poly(ADP-ribose) polymerase catalytic domain (PARP)	Poly(ADP-ribose) polymerase catalytic domain	Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...	Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Protein mono-ADP-ribosyltransferase PARP4	pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity NAD+-protein mono-ADP-ribosyltransferase activity catalytic activity DNA binding binding nucleic acid binding NAD+-protein-aspartate ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding enzyme binding pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity NAD+-protein mono-ADP-ribosyltransferase activity catalytic activity DNA binding binding nucleic acid binding NAD+-protein-aspartate ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding enzyme binding NAD+-protein-glutamate ADP-ribosyltransferase activity NAD+ poly-ADP-ribosyltransferase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA repair defense response inflammatory response	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen protein-containing complex ribonucleoprotein complex polymeric cytoskeletal fiber spindle intracellular membraneless organelle spindle microtubule cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR031273	Protein mono-ADP-ribosyltransferase PARP4	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013694	VIT domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001357	BRCT domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036420	BRCT domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036616	Poly(ADP-ribose) polymerase, regulatory domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004102	Poly(ADP-ribose) polymerase, regulatory domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002035	von Willebrand factor, type A	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: Q9UKK3	malignant colon neoplasm benign colon neoplasm diabetes mellitus lung carcinoma Malignant tumor of peritoneum ovarian cancer colonic neoplasm ovarian epithelial tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.