9SVY | pdb_00009svy

XRCC3-RAD51C-RAD51D-XRCC2 (XRCC3 complex) capping a RAD51 filament on partially duplex DNA

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA repair protein RAD51 homolog 4	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA damage sensor activity molecular sensor activity ATP-dependent DNA damage sensor activity molecular function regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA damage sensor activity molecular sensor activity ATP-dependent DNA damage sensor activity molecular function regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding cytoskeletal protein binding protein binding gamma-tubulin binding tubulin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	homologous recombination sexual reproduction reproductive process meiotic cell cycle process nucleobase-containing compound metabolic process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process DNA recombination meiotic cell cycle homologous recombination sexual reproduction reproductive process meiotic cell cycle process nucleobase-containing compound metabolic process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process DNA recombination meiotic cell cycle organelle fission primary metabolic process DNA metabolic process nucleic acid metabolic process reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process metabolic process cellular process macromolecule metabolic process mitotic recombination telomere organization chromosome organization telomere maintenance telomere maintenance via recombination cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress interstrand cross-link repair DNA repair DNA strand invasion double-strand break repair recombinational repair double-strand break repair via homologous recombination regulation of biological process regulation of cellular process biological regulation regulation of cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus Rad51B-Rad51C-Rad51D-XRCC2 complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle DNA recombinase mediator complex centrosome microtubule organizing center cytoskeleton membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus Rad51B-Rad51C-Rad51D-XRCC2 complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle DNA recombinase mediator complex centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen replication fork chromosome chromosome, telomeric region chromosomal region
D [auth C]	DNA repair protein RAD51 homolog 3	ATP-dependent activity, acting on DNA DNA damage sensor activity molecular sensor activity catalytic activity, acting on DNA ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid molecular function regulator activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ATP-dependent activity, acting on DNA DNA damage sensor activity molecular sensor activity catalytic activity, acting on DNA ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid molecular function regulator activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding endonuclease activity hydrolase activity crossover junction DNA endonuclease activity DNA nuclease activity DNA endonuclease activity DNA endonuclease activity, producing 3'-phosphomonoesters hydrolase activity, acting on ester bonds nuclease activity	cellular response to stimulus sexual reproduction response to stimulus reproductive process meiotic cell cycle process cellular component organization cellular component biogenesis protein-DNA complex organization nucleobase-containing compound metabolic process DNA recombinase assembly cellular component assembly cellular response to stress response to stress protein-containing complex assembly DNA repair complex assembly cellular response to stimulus sexual reproduction response to stimulus reproductive process meiotic cell cycle process cellular component organization cellular component biogenesis protein-DNA complex organization nucleobase-containing compound metabolic process DNA recombinase assembly cellular component assembly cellular response to stress response to stress protein-containing complex assembly DNA repair complex assembly recombinational repair cell cycle cellular component organization or biogenesis double-strand break repair via homologous recombination cell cycle process DNA repair double-strand break repair protein-containing complex organization meiotic cell cycle DNA recombination protein-DNA complex assembly primary metabolic process DNA metabolic process meiotic DNA recombinase assembly double-strand break repair via synthesis-dependent strand annealing nucleic acid metabolic process meiosis I cell cycle process DNA damage response cellular process metabolic process macromolecule metabolic process developmental process spermatogenesis multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation organelle organization female meiosis sister chromatid cohesion chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion homologous recombination meiosis I meiotic nuclear division reciprocal homologous recombination organelle fission reciprocal meiotic recombination nuclear division mitotic recombination telomere organization telomere maintenance telomere maintenance via recombination male meiosis I male meiotic nuclear division regulation of cell cycle phase transition regulation of cellular process G2/M transition of mitotic cell cycle positive regulation of biological process cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle regulation of cell cycle positive regulation of cellular process cell cycle G2/M phase transition positive regulation of G2/M transition of mitotic cell cycle regulation of biological process regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation regulation of cell cycle G2/M phase transition positive regulation of cell cycle G2/M phase transition positive regulation of cell cycle regulation of mitotic cell cycle phase transition mitotic cell cycle process positive regulation of cell cycle phase transition mitotic cell cycle phase transition	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell junction protein-containing complex nucleus Rad51B-Rad51C-Rad51D-XRCC2 complex nuclear protein-containing complex DNA recombinase mediator complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell junction protein-containing complex nucleus Rad51B-Rad51C-Rad51D-XRCC2 complex nuclear protein-containing complex DNA recombinase mediator complex cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen membraneless organelle replication fork intracellular membraneless organelle chromosome perinuclear region of cytoplasm Rad51C-XRCC3 complex
E [auth D]	DNA repair protein XRCC3	ATP-dependent activity, acting on DNA DNA damage sensor activity molecular sensor activity catalytic activity, acting on DNA ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid molecular function regulator activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ATP-dependent activity, acting on DNA DNA damage sensor activity molecular sensor activity catalytic activity, acting on DNA ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid molecular function regulator activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA recombination mitotic recombination resolution of mitotic recombination intermediates primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process resolution of DNA recombination intermediates cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA recombination mitotic recombination resolution of mitotic recombination intermediates primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process resolution of DNA recombination intermediates metabolic process macromolecule metabolic process positive regulation of cell communication regulation of cellular process regulation of cell cycle phase transition positive regulation of signal transduction positive regulation of cell cycle checkpoint negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of signal transduction regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of cell cycle checkpoint negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction cell cycle mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process regulation of spindle checkpoint sister chromatid segregation positive regulation of intracellular signal transduction regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of response to stimulus positive regulation of mitotic cell cycle spindle assembly checkpoint regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic spindle checkpoint signaling regulation of mitotic cell cycle spindle assembly checkpoint spindle assembly checkpoint signaling positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization positive regulation of response to stimulus regulation of mitotic cell cycle regulation of intracellular signal transduction negative regulation of cellular process mitotic sister chromatid segregation positive regulation of cell cycle process negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis regulation of cell cycle negative regulation of chromosome separation positive regulation of cellular process cell cycle process positive regulation of spindle checkpoint mitotic nuclear division regulation of signaling negative regulation of mitotic cell cycle phase transition organelle fission biological regulation chromosome organization negative regulation of cell cycle process positive regulation of cell cycle cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation negative regulation of nuclear division negative regulation of organelle organization chromosome separation regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle regulation of cell communication metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition positive regulation of signaling telomere organization telomere maintenance telomere maintenance via recombination microtubule organizing center organization regulation of centrosome cycle microtubule cytoskeleton organization regulation of microtubule-based process centrosome duplication centrosome cycle regulation of centrosome duplication microtubule-based process cytoskeleton organization interstrand cross-link repair DNA repair formation of extrachromosomal circular DNA cellular component biogenesis cellular component assembly telomere maintenance via telomere trimming t-circle formation double-strand break repair recombinational repair double-strand break repair via homologous recombination double-strand break repair via synthesis-dependent strand annealing telomeric loop disassembly	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen membraneless organelle replication fork intracellular membraneless organelle chromosome perinuclear region of cytoplasm protein-containing complex nuclear protein-containing complex Rad51C-XRCC3 complex DNA recombinase mediator complex chromosome, telomeric region chromosomal region
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	DNA repair protein RAD51 homolog 1	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA strand exchange activity DNA damage sensor activity molecular sensor activity ATP-dependent DNA damage sensor activity molecular function regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA strand exchange activity DNA damage sensor activity molecular sensor activity ATP-dependent DNA damage sensor activity molecular function regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding chromatin binding DNA binding double-stranded DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides nucleic acid conformation isomerase activity isomerase activity DNA helicase activity single-stranded DNA helicase activity helicase activity macromolecular conformation isomerase activity DNA polymerase binding enzyme binding single-stranded DNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus regulation of DNA recombination regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus regulation of DNA recombination regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair double-strand break repair regulation of biological process DNA recombination biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity DNA replication replication fork processing cellular response to nitrogen compound response to alcohol response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to alkaloid cellular response to chemical stimulus cellular response to alcohol response to camptothecin cellular response to camptothecin cellular response to alkaloid homologous recombination sexual reproduction reproductive process meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus cellular response to ionizing radiation cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus interstrand cross-link repair response to toxic substance DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint regulation of intracellular signal transduction negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle regulation of signaling regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint DNA strand invasion response to glycoside response to glucoside cellular component biogenesis protein-DNA complex organization DNA recombinase assembly cellular component assembly protein-containing complex assembly DNA repair complex assembly protein-containing complex organization protein-DNA complex assembly double-strand break repair via synthesis-dependent strand annealing double-strand break repair involved in meiotic recombination replication-born double-strand break repair via sister chromatid exchange chromosome organization chromosome organization involved in meiotic cell cycle cellular response to gamma radiation response to gamma radiation mitotic recombination telomere organization telomere maintenance telomere maintenance via recombination response to cisplatin cellular response to cisplatin mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle mitotic cell cycle process cell cycle DNA replication maintenance of fidelity mitotic recombination-dependent replication fork processing mitotic DNA replication maintenance of fidelity cellular response to hydroxyurea response to hydroxyurea telomere maintenance via telomere lengthening	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome synapse intermediate filament cytoskeleton presynaptic cytoskeleton presynapse cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome synapse intermediate filament cytoskeleton presynaptic cytoskeleton presynapse cytoskeleton cell junction presynaptic intermediate filament cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen perinuclear region of cytoplasm male germ cell nucleus germ cell nucleus chromosome, telomeric region chromosomal region protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex mitochondrion nucleolus condensed chromosome condensed nuclear chromosome centrosome microtubule organizing center microtubule cytoskeleton nucleoplasm lateral element synaptonemal structure synaptonemal complex site of double-strand break site of DNA damage mitochondrial matrix nuclear body PML body
F [auth A]	DNA repair protein XRCC2	ATP-dependent activity, acting on DNA DNA damage sensor activity molecular sensor activity catalytic activity, acting on DNA ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid molecular function regulator activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ATP-dependent activity, acting on DNA DNA damage sensor activity molecular sensor activity catalytic activity, acting on DNA ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid molecular function regulator activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding	cellular process cell cycle mitotic cell cycle developmental process neurogenesis multicellular organism development multicellular organismal process cellular developmental process cell differentiation anatomical structure development nervous system development system development somitogenesis epithelium development cellular process cell cycle mitotic cell cycle developmental process neurogenesis multicellular organism development multicellular organismal process cellular developmental process cell differentiation anatomical structure development nervous system development system development somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis response to X-ray response to ionizing radiation response to stimulus response to radiation response to abiotic stimulus regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death cell death fibroblast apoptotic process apoptotic process programmed cell death regulation of fibroblast apoptotic process neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process regulation of neuron apoptotic process in utero embryonic development nucleobase-containing compound metabolic process DNA recombination metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process DNA strand invasion nucleic acid metabolic process cellular response to stimulus double-strand break repair cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair microtubule organizing center organization microtubule cytoskeleton organization cellular component organization organelle organization centrosome cycle microtubule-based process cellular component organization or biogenesis cytoskeleton organization cell cycle process response to gamma radiation positive regulation of nervous system development regulation of developmental process positive regulation of biological process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of cellular process regulation of multicellular organismal development positive regulation of cell development positive regulation of multicellular organismal process multicellular organism growth developmental growth growth sexual reproduction reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus Rad51B-Rad51C-Rad51D-XRCC2 complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle DNA recombinase mediator complex centrosome microtubule organizing center cytoskeleton membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus Rad51B-Rad51C-Rad51D-XRCC2 complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle DNA recombinase mediator complex centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen replication fork chromosome
C [auth N]	dN-21nt	-	-	-
B [auth M]	dN-31nt	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR051988	Homologous Recombination Repair RAD51 Paralog	Family
A [auth B]	IPR003593	AAA+ ATPase domain	Domain
A [auth B]	IPR047323	DNA repair protein RAD51 homolog 4, C-terminal	Domain
A [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth B]	IPR016467	DNA recombination and repair protein, RecA-like	Family
A [auth B]	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
A [auth B]	IPR013632	Rad51-like, C-terminal	Domain
A [auth B]	IPR048943	RAD51D, N-terminal domain	Domain
D [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth C]	IPR016467	DNA recombination and repair protein, RecA-like	Family
D [auth C]	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
D [auth C]	IPR013632	Rad51-like, C-terminal	Domain
D [auth C]	IPR052093	Homologous Recombination Repair Mediator	Family
E [auth D]	IPR047348	DNA repair protein XRCC3-like, C-terminal	Domain
E [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth D]	IPR016467	DNA recombination and repair protein, RecA-like	Family
E [auth D]	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
E [auth D]	IPR013632	Rad51-like, C-terminal	Domain
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface	Domain
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR003593	AAA+ ATPase domain	Domain
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR011941	DNA recombination/repair protein Rad51	Family
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR016467	DNA recombination and repair protein, RecA-like	Family
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR013632	Rad51-like, C-terminal	Domain
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	IPR010995	DNA repair Rad51/transcription factor NusA, alpha-helical	Homologous Superfamily
F [auth A]	IPR030547	DNA repair protein XRCC2	Family
F [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth A]	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
F [auth A]	IPR013632	Rad51-like, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: O75771	breast-ovarian cancer, familial, susceptibility to, 4 hereditary breast ovarian cancer syndrome Chromosome Deletion ovarian cancer hereditary breast carcinoma ovarian neoplasm Sjogren syndrome cancer osteosarcoma malignant mesothelioma rheumatoid arthritis
D [auth C]	Pharos: O43502	Fanconi anemia Fanconi anemia complementation group O ovarian cancer breast-ovarian cancer, familial, susceptibility to, 3 hereditary breast ovarian cancer syndrome breast carcinoma breast cancer Mammary Neoplasms nasopharyngeal carcinoma ovarian neoplasm tuberculosis acute myeloid leukemia cancer aplastic anemia congenital anemia Fanconi anemia Fanconi anemia complementation group O ovarian cancer breast-ovarian cancer, familial, susceptibility to, 3 hereditary breast ovarian cancer syndrome breast carcinoma breast cancer Mammary Neoplasms nasopharyngeal carcinoma ovarian neoplasm tuberculosis acute myeloid leukemia cancer aplastic anemia congenital anemia esophageal atresia/tracheoesophageal fistula hematopoietic and lymphoid system neoplasm inherited aplastic anemia medulloblastoma hereditary breast carcinoma intellectual disability
E [auth D]	Pharos: O43542	melanoma melanoma, cutaneous malignant, susceptibility to, 6 skin basal cell carcinoma breast cancer Neoplasm Invasiveness skin neoplasm breast carcinoma esophageal cancer head and neck cancer lead poisoning skin cancer anorexia nervosa osteosarcoma benign mesothelioma hereditary breast carcinoma melanoma melanoma, cutaneous malignant, susceptibility to, 6 skin basal cell carcinoma breast cancer Neoplasm Invasiveness skin neoplasm breast carcinoma esophageal cancer head and neck cancer lead poisoning skin cancer anorexia nervosa osteosarcoma benign mesothelioma hereditary breast carcinoma large cell medulloblastoma neoplasm of esophagus attention deficit hyperactivity disorder, inattentive type bipolar disorder skin pigmented basal cell carcinoma gastric cancer head and neck neoplasm hereditary diffuse gastric adenocarcinoma malignant tumor of neck mesothelioma neoplasm of neck autism spectrum disorder cutaneous melanoma gastric neoplasm inherited disease susceptibility
G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], G [auth E], H [auth F], I [auth G], J [auth H], K [auth I], L [auth J], M [auth K]	Pharos: Q06609	Fanconi anemia mirror movements 2 breast cancer breast carcinoma Fanconi anemia complementation group R head and neck cancer Micronuclei, Chromosome-Defective invasive ductal breast carcinoma malignant glioma malignant tumor of neck medulloblastoma neoplasm of neck aplastic anemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Fanconi anemia mirror movements 2 breast cancer breast carcinoma Fanconi anemia complementation group R head and neck cancer Micronuclei, Chromosome-Defective invasive ductal breast carcinoma malignant glioma malignant tumor of neck medulloblastoma neoplasm of neck aplastic anemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm cancer psoriasis hereditary breast carcinoma inherited aplastic anemia large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma atypical teratoid rhabdoid tumor ovarian disease primitive neuroectodermal tumor head and neck neoplasm hereditary breast ovarian cancer syndrome inherited disease susceptibility lung cancer osteosarcoma pancreatic intraductal papillary-mucinous carcinoma breast disease prostate carcinoma familial congenital mirror movements glioblastoma IgA glomerulonephritis
F [auth A]	Pharos: O43543	Fanconi anemia Fanconi anemia complementation group U breast carcinoma breast cancer aplastic anemia inherited aplastic anemia Malignant neoplasm of breast ovarian cancer astrocytic tumor cancer hematopoietic and lymphoid system neoplasm lung adenocarcinoma non-small cell lung carcinoma primary ovarian failure hereditary breast carcinoma Fanconi anemia Fanconi anemia complementation group U breast carcinoma breast cancer aplastic anemia inherited aplastic anemia Malignant neoplasm of breast ovarian cancer astrocytic tumor cancer hematopoietic and lymphoid system neoplasm lung adenocarcinoma non-small cell lung carcinoma primary ovarian failure hereditary breast carcinoma malignant ependymoma oligodendroglioma