9B7B | pdb_00009b7b

Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA01:01/HLA-DRB104:01)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8040455	3000521	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054671	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054671	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	MHC antigen-recognition domain	8040455	3000521	SCOP2B (2022-06-29)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C, G	Heavy Chain	IGHV4	-	hla class ii histocompatibility antigen, dr alpha chain \| hemagglutinin ha1 chain, hla class ii histocompatibilityantigen dr beta chain	SAbDab (2025-07-04)
D, H	Light Chain	IGKV1	Kappa	hla class ii histocompatibility antigen, dr alpha chain \| hemagglutinin ha1 chain, hla class ii histocompatibilityantigen dr beta chain	SAbDab (2025-07-04)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain		Domain
A, E	PF00993	Class II histocompatibility antigen, alpha domain (MHC_II_alpha)	Class II histocompatibility antigen, alpha domain		Domain
B, F	PF00969	Class II histocompatibility antigen, beta domain (MHC_II_beta)	Class II histocompatibility antigen, beta domain		Domain
B, F	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E	HLA class II histocompatibility antigen, DR alpha chain	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity polysaccharide binding carbohydrate binding binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity polysaccharide binding carbohydrate binding protein binding signaling receptor binding T cell receptor binding	multicellular organismal process regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion multicellular organismal process regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation CD4-positive, alpha-beta T cell activation positive regulation of leukocyte activation alpha-beta T cell activation regulation of immune system process regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of cellular process regulation of biological process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation positive regulation of alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process cellular process regulation of lymphocyte activation response to stimulus immune response positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus regulation of immune response antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen system process nervous system process cognition peptide antigen assembly with MHC class II protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class II protein complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly MHC protein complex assembly cellular component organization or biogenesis dendritic cell antigen processing and presentation myeloid dendritic cell antigen processing and presentation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity positive regulation of immune effector process positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response regulation of cell development CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response multicellular organism development cell differentiation regulation of T-helper cell differentiation anatomical structure development T cell differentiation developmental process T-helper cell differentiation leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis T cell differentiation involved in immune response regulation of hemopoiesis immunological memory formation process positive regulation of T cell differentiation positive regulation of developmental process positive regulation of memory T cell differentiation positive regulation of cell development memory T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of memory T cell differentiation immunological memory process positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of regulatory T cell differentiation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of regulatory T cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulatory T cell differentiation	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell surface MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome late endosome membrane endomembrane system late endosome lytic vacuole vacuole lysosome organelle subcompartment lumenal side of endoplasmic reticulum membrane side of membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane immunological synapse vacuolar membrane lytic vacuole membrane lysosomal membrane Golgi membrane Golgi apparatus early endosome early endosome membrane autolysosome autolysosome membrane secondary lysosome Golgi apparatus subcompartment trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane
B, F	Hemagglutinin HA1 chain, HLA class II histocompatibility antigen DR beta chain	-	antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process response to stimulus immune response adaptive immune response	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle
C, G	h44H10-V22 Antibody, heavy chain	-	-	-
D, H	h44H10-V22 Antibody, light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, E	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
A, E	IPR003597	Immunoglobulin C1-set	Domain
A, E	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, E	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, E	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
A, E	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, E	IPR007110	Immunoglobulin-like domain	Domain
A, E	IPR001003	MHC class II, alpha chain, N-terminal	Domain
B, F	IPR000353	MHC class II, beta chain, N-terminal	Domain
B, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, F	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
B, F	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
B, F	IPR003597	Immunoglobulin C1-set	Domain
B, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, F	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
B, F	IPR007110	Immunoglobulin-like domain	Domain
B, F	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E	Pharos: P01903	toxic shock syndrome lung carcinoma multiple sclerosis juvenile dermatomyositis systemic sclerosis ulcerative colitis Parkinson disease Sjogren syndrome Crohn disease Graham Little Piccardi Lassueur syndrome pancreatic ductal adenocarcinoma Hashimoto thyroiditis pilocytic astrocytoma Hodgkins lymphoma psoriatic arthritis toxic shock syndrome lung carcinoma multiple sclerosis juvenile dermatomyositis systemic sclerosis ulcerative colitis Parkinson disease Sjogren syndrome Crohn disease Graham Little Piccardi Lassueur syndrome pancreatic ductal adenocarcinoma Hashimoto thyroiditis pilocytic astrocytoma Hodgkins lymphoma psoriatic arthritis invasive ductal breast carcinoma skin basal cell carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy systemic lupus erythematosus astrocytic tumor Becker muscular dystrophy malignant glioma celiac disease dermatomyositis neoplasm of mature B-cells Down syndrome non-alcoholic fatty liver disease esophageal adenocarcinoma osteoporosis Graham Little-Piccardi-Lassueur syndrome pancreatic intraductal papillary-mucinous carcinoma head and neck cancer primary biliary cholangitis IgA glomerulonephritis squamous cell lung carcinoma lung adenocarcinoma atopic eczema lymphoplasmacytic lymphoma breast cancer marginal zone lymphoma chronic obstructive pulmonary disease diabetes mellitus nephrotic syndrome Duchenne muscular dystrophy non-small cell lung carcinoma glioblastoma ovarian cancer Graves disease heart disease prostate carcinoma interstitial cystitis juvenile idiopathic arthritis subependymal giant cell astrocytoma alopecia areata lung cancer temporal arteritis vitiligo autism spectrum disorder malignant ependymoma breast carcinoma membranous glomerulonephritis myasthenia gravis diffuse scleroderma nodular sclerosis classical Hodgkin lymphoma osteoarthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.