Annotations: 9BTM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	Ras-like P-loop GTPases	8057492	3002022	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
B [auth A]	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motili ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Leucine-rich repeat protein SHOC-2	phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity volume-sensitive anion channel activity monoatomic anion transmembrane transporter activity passive transmembrane transporter activity phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity volume-sensitive anion channel activity monoatomic anion transmembrane transporter activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding protein phosphatase 1 binding	multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation cellular response to stimulus cellular response to growth factor stimulus response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cellular response to nerve growth factor stimulus cell communication cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor response to growth factor signal transduction regulation of signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization regulation of cell projection organization neuron development regulation of plasma membrane bounded cell projection organization positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation response to fibroblast growth factor cell surface receptor protein tyrosine kinase signaling pathway fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus enzyme-linked receptor protein signaling pathway import into cell nitrogen compound transport guanine nucleotide transmembrane transport organic anion transport nucleotide transport transport purine ribonucleotide transport import across plasma membrane carbohydrate derivative transport establishment of localization purine nucleotide transport transmembrane transport adenine nucleotide transport localization nucleotide transmembrane transport cyclic-GMP-AMP transmembrane import across plasma membrane guanine nucleotide transport cyclic nucleotide transport nucleobase-containing compound transport organophosphate ester transport purine-containing compound transmembrane transport negative regulation of cell population proliferation negative regulation of neural precursor cell proliferation cell population proliferation regulation of cell population proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation cellular response to nitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to growth hormone stimulus cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus response to hormone response to chemical cellular response to hormone stimulus positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction positive regulation of response to stimulus regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of intracellular signal transduction positive regulation of small GTPase mediated signal transduction positive regulation of signaling	phosphatase complex protein-containing complex protein phosphatase type 1 complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen phosphatase complex protein-containing complex protein phosphatase type 1 complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B [auth A]	GTPase NRas	guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GTP binding purine ribonucleoside triphosphate binding	developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation biological regulation developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cellular process cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction small GTPase-mediated signal transduction Ras protein signal transduction	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane Golgi apparatus Golgi membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol cell periphery plasma membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A [auth B]	IPR001611	Leucine-rich repeat	Repeat
A [auth B]	IPR050216	Leucine-rich repeat domain-containing protein	Family
A [auth B]	IPR055414	Disease resistance R13L4/SHOC-2-like, LRR domain	Domain
A [auth B]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
B [auth A]	IPR005225	Small GTP-binding domain	Domain
B [auth A]	IPR020849	Small GTPase, Ras-type	Family
B [auth A]	IPR001806	Small GTPase	Family
B [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: Q9UQ13	Noonan syndrome Noonan syndrome-like disorder with loose anagen hair 1 disease of pilosebaceous unit cardiofaciocutaneous syndrome Female Pseudo-Turner Syndrome intellectual disability malignant glioma Noonan syndrome-like disorder with loose anagen hair plasma cell myeloma Costello syndrome hydrops fetalis large cell medulloblastoma hypertrophic cardiomyopathy lymphoplasmacytic lymphoma Noonan syndrome with multiple lentigines Noonan syndrome Noonan syndrome-like disorder with loose anagen hair 1 disease of pilosebaceous unit cardiofaciocutaneous syndrome Female Pseudo-Turner Syndrome intellectual disability malignant glioma Noonan syndrome-like disorder with loose anagen hair plasma cell myeloma Costello syndrome hydrops fetalis large cell medulloblastoma hypertrophic cardiomyopathy lymphoplasmacytic lymphoma Noonan syndrome with multiple lentigines ovarian cancer
B [auth A]	Pharos: P01111	juvenile myelomonocytic leukemia Noonan syndrome large congenital melanocytic nevus autoimmune lymphoproliferative syndrome thyroid cancer, nonmedullary, 2 Noonan syndrome 6 melanoma neurofibrosarcoma nevus, epidermal neurocutaneous melanocytosis cancer colorectal cancer neuroblastoma autoimmune lymphoproliferative syndrome type 4 cutaneous melanoma juvenile myelomonocytic leukemia Noonan syndrome large congenital melanocytic nevus autoimmune lymphoproliferative syndrome thyroid cancer, nonmedullary, 2 Noonan syndrome 6 melanoma neurofibrosarcoma nevus, epidermal neurocutaneous melanocytosis cancer colorectal cancer neuroblastoma autoimmune lymphoproliferative syndrome type 4 cutaneous melanoma acute myeloid leukemia acute promyelocytic leukemia Leukemia, Megakaryoblastic, of Down Syndrome rectal neoplasm lymphoma B-cell neoplasm woolly hair nevus gastric adenocarcinoma hematologic disease hydrops fetalis non-small cell lung carcinoma inflammatory linear verrucous epidermal nevus ovarian cancer chronic myelogenous leukemia, BCR-ABL1 positive thyroid gland carcinoma congenital anemia medulloblastoma giant congenital nevus Hutchinson-Gilford progeria syndrome atypical teratoid rhabdoid tumor hypertrophic cardiomyopathy autoimmune lymphoproliferative syndrome type 2B intellectual disability pancreatic ductal adenocarcinoma rectal cancer Charcot-Marie-Tooth disease rectum adenocarcinoma chronic myelomonocytic leukemia lung adenocarcinoma colorectal carcinoma malignant glioma thyroid gland papillary carcinoma verrucous nevus glioblastoma hydrocephalus IgA glomerulonephritis Noonan syndrome 1 osteosarcoma juvenile dermatomyositis plasma cell myeloma breast cancer leukemia rectal carcinoma cholangiocarcinoma linear nevus sebaceus syndrome skin disease colorectal adenocarcinoma lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.