9DA2 | pdb_00009da2

Crystal structure of human DNPH1 bound to inhibitor 1b

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05014	Nucleoside 2-deoxyribosyltransferase (Nuc_deoxyrib_tr)	Nucleoside 2-deoxyribosyltransferase	Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	5-hydroxymethyl-dUMP N-hydrolase	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity hydrolase activity, acting on glycosyl bonds hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity 5-hydroxymethyl-dUMP N-hydrolase activity	regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis positive regulation of cellular process nucleoside phosphate metabolic process deoxyribonucleoside monophosphate catabolic process nucleoside monophosphate catabolic process catabolic process organophosphate catabolic process primary metabolic process nucleoside phosphate catabolic process deoxyribonucleoside monophosphate metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process small molecule metabolic process nucleoside monophosphate metabolic process phosphorus metabolic process purine nucleotide catabolic process purine-containing compound catabolic process nucleotide metabolic process purine-containing compound metabolic process purine nucleotide metabolic process nucleotide catabolic process carbohydrate derivative biosynthetic process glycosyl compound metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process nucleoside salvage carbohydrate derivative metabolic process nucleoside biosynthetic process nucleobase-containing compound biosynthetic process nucleoside metabolic process nucleobase-containing small molecule biosynthetic process metabolic compound salvage biosynthetic process developmental process epithelium development cellular developmental process cell differentiation anatomical structure development tissue development epithelial cell differentiation	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007710	Nucleoside 2-deoxyribosyltransferase	Family
A, B	IPR051239	2'-Deoxynucleoside 5'-phosphate N-hydrolase	Family
A, B	IPR028607	2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O43598	lung cancer psoriasis malignant ependymoma X-linked mixed deafness with perilymphatic gusher ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.