9DQA | pdb_00009dqa

Crystal structure of bovine RPE65 in complex with EYE-002

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Retinoid isomerohydrolase	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity beta-carotene 15,15'-dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity isomerase activity retinol isomerase activity cis-trans isomerase activity ion binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity beta-carotene 15,15'-dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity isomerase activity retinol isomerase activity cis-trans isomerase activity ion binding binding anion binding phosphatidylglycerol binding phospholipid binding lipid binding cardiolipin binding small molecule binding cation binding phosphatidylcholine binding quaternary ammonium group binding retinyl-palmitate esterase activity all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity metal ion binding identical protein binding protein binding modified amino acid binding phosphatidylserine binding	detection of light stimulus involved in visual perception detection of light stimulus response to light stimulus multicellular organismal process detection of external stimulus sensory perception of light stimulus system process nervous system process response to stimulus response to external stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of light stimulus involved in sensory perception detection of light stimulus involved in visual perception detection of light stimulus response to light stimulus multicellular organismal process detection of external stimulus sensory perception of light stimulus system process nervous system process response to stimulus response to external stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of light stimulus involved in sensory perception response to abiotic stimulus response to radiation visual perception detection of stimulus involved in sensory perception multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis diterpenoid metabolic process retinal metabolic process primary metabolic process aldehyde metabolic process retinoid metabolic process olefinic compound metabolic process metabolic process cellular process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process pigment metabolic process carotenoid biosynthetic process isoprenoid biosynthetic process lipid biosynthetic process pigment biosynthetic process terpenoid biosynthetic process zeaxanthin metabolic process zeaxanthin biosynthetic process xanthophyll biosynthetic process biosynthetic process tetraterpenoid biosynthetic process xanthophyll metabolic process carotenoid metabolic process	cellular anatomical structure membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network cellular anatomical structure membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004294	Carotenoid oxygenase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.