9EID | pdb_00009eid

A broad-substrate spectrum lactate racemase A from Isosphaera pallida in complex with D-2-Hydroxybutyrate

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09861	Lactate racemase N-terminal domain (Lar_N)	Lactate racemase N-terminal domain	This is the N-terminal domain found in Lactate racemase enzymes EC:5.1.2.1. LarA is a nickel-dependent lactate racemase from the larA-E operon of Lactobacillus plantarum, whereas LarB, LarC and LarE are accessory proteins required for the incorporati ...	This is the N-terminal domain found in Lactate racemase enzymes EC:5.1.2.1. LarA is a nickel-dependent lactate racemase from the larA-E operon of Lactobacillus plantarum, whereas LarB, LarC and LarE are accessory proteins required for the incorporation of Ni in the lactate racemase apoprotein. LarA contains 18 beta-strands and 16 alpha-helices arranged in a novel fold composed of two domains of similar size. This entry represents the N-terminal domain of LarA and related proteins [1].	Domain
A	PF21113	Lactate racemase C-terminal domain (LarA_C)	Lactate racemase C-terminal domain	This entry represents the C-terminal domain of the nickel-dependent lactate racemase enzyme (LarA) [1]. LarA is part of a superfamily containing many different enzymes [4]. These include malate racemases, phenyllactate racemase, one alpha-hydroxyglut ...	This entry represents the C-terminal domain of the nickel-dependent lactate racemase enzyme (LarA) [1]. LarA is part of a superfamily containing many different enzymes [4]. These include malate racemases, phenyllactate racemase, one alpha-hydroxyglutarate racemase, D-gluconate 2-epimerase, a short-chain aliphatic alpha-hydroxyacid racemase [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	A broad-substrate spectrum lactate racemase A	racemase and epimerase activity, acting on hydroxy acids and derivatives isomerase activity racemase and epimerase activity lactate racemase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR048520	Lactate racemase, C-terminal domain	Domain
A	IPR043166	LarA-like, C-terminal domain	Homologous Superfamily
A	IPR048068	LarA-like	Family
A	IPR018657	LarA-like, N-terminal	Domain
A	IPR047926	Nickel-dependent lactate racemase LarA	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.