9GIS | pdb_00009gis

BFL1 covalently bound to inhibitor compound 17

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Bcl-2-related protein A1	passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity	cellular response to stimulus regulation of biological process regulation of cellular process signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling biological regulation cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand cellular process cellular response to stimulus regulation of biological process regulation of cellular process signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling biological regulation cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand cellular process signal transduction apoptotic process programmed cell death intracellular signal transduction cellular response to stress DNA damage response response to stress intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway organelle fusion cellular component organization organelle organization mitochondrial fusion cellular component organization or biogenesis mitochondrion organization negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process apoptotic mitochondrial changes release of cytochrome c from mitochondria	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
A, B	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
A, B	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A, B	IPR013282	Bcl-2-related protein A1	Family
A, B	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A, B	IPR002475	Bcl2-like	Family
A, B	IPR026298	Bcl-2 family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q16548	rheumatoid arthritis esophageal cancer breast carcinoma malignant mesothelioma Mammary Neoplasms nasopharyngeal carcinoma osteosarcoma Sjogren syndrome bipolar disorder chronic obstructive pulmonary disease ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma lung cancer malignant ependymoma rheumatoid arthritis esophageal cancer breast carcinoma malignant mesothelioma Mammary Neoplasms nasopharyngeal carcinoma osteosarcoma Sjogren syndrome bipolar disorder chronic obstructive pulmonary disease ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma lung cancer malignant ependymoma neoplasm of esophagus psoriasis ulcerative colitis breast cancer cutaneous lupus erythematosus head and neck cancer large cell medulloblastoma lung carcinoma malignant glioma malignant pancreatic neoplasm medulloblastoma non-small cell lung carcinoma cystic fibrosis gastric carcinoma interstitial cystitis lung adenocarcinoma lymphoplasmacytic lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.