Annotations: 9HJS

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00348	Polyprenyl synthetase (polyprenyl_synt)	Polyprenyl synthetase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Geranylgeranyl pyrophosphate synthase	prenyl diphosphate synthase activity dimethylallyltranstransferase activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity geranylgeranyl diphosphate synthase activity (2E,6E)-farnesyl diphosphate synthase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding prenyl diphosphate synthase activity dimethylallyltranstransferase activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity geranylgeranyl diphosphate synthase activity (2E,6E)-farnesyl diphosphate synthase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	primary metabolic process metabolic process cellular process isoprenoid metabolic process lipid metabolic process isoprenoid biosynthetic process lipid biosynthetic process terpenoid biosynthetic process phospholipid biosynthetic process farnesyl diphosphate metabolic process phospholipid metabolic process biosynthetic process farnesyl diphosphate biosynthetic process organophosphate metabolic process primary metabolic process metabolic process cellular process isoprenoid metabolic process lipid metabolic process isoprenoid biosynthetic process lipid biosynthetic process terpenoid biosynthetic process phospholipid biosynthetic process farnesyl diphosphate metabolic process phospholipid metabolic process biosynthetic process farnesyl diphosphate biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process terpenoid metabolic process geranyl diphosphate biosynthetic process geranyl diphosphate metabolic process geranylgeranyl diphosphate biosynthetic process geranylgeranyl diphosphate metabolic process	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR008949	Isoprenoid synthase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR033749	Polyprenyl synthetase, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR000092	Polyprenyl synthetase-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: O95749	breast cancer gastric carcinoma ovarian cancer psoriasis congenital muscular dystrophy hepatocellular carcinoma pancreatic intraductal papillary-mucinous carcinoma tuberculosis gastric cancer malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.