9L90 | pdb_00009l90

The crystal structure of human RyR3 Repeat12 domain in complex with Dantrolene and AMP-PCP

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Ryanodine receptor 3	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly gated calcium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly gated calcium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity ligand-gated calcium channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity calcium-induced calcium release activity ryanodine-sensitive calcium-release channel activity protein binding calmodulin binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis cellular response to nitrogen compound cellular response to stimulus response to stimulus protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis cellular response to nitrogen compound cellular response to stimulus response to stimulus cellular response to caffeine response to nitrogen compound response to purine-containing compound response to alkaloid cellular response to chemical stimulus response to chemical cellular response to alkaloid cellular response to purine-containing compound response to caffeine inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular response to metal ion response to metal ion cellular response to calcium ion response to calcium ion transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport response to magnesium ion cellular response to magnesium ion regulation of localization cellular localization regulation of cellular process negative regulation of biological process negative regulation of sequestering of calcium ion maintenance of location in cell negative regulation of cellular process regulation of sequestering of calcium ion regulation of biological process calcium ion transmembrane import into cytosol sequestering of calcium ion biological regulation maintenance of location release of sequestered calcium ion into cytosol cellular response to ATP response to organophosphorus response to oxygen-containing compound response to ATP cellular response to oxygen-containing compound sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum	cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane cell periphery sarcolemma plasma membrane smooth endoplasmic reticulum protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003032	Ryanodine receptor Ryr	Domain
A, B, C, D	IPR036300	Mir domain superfamily	Homologous Superfamily
A, B, C, D	IPR000699	RIH domain	Domain
A, B, C, D	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, C, D	IPR013662	RyR/IP3R Homology associated domain	Domain
A, B, C, D	IPR016093	MIR motif	Domain
A, B, C, D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D	IPR035761	Ryanodine receptor, SPRY domain 1	Domain
A, B, C, D	IPR014821	Inositol 1,4,5-trisphosphate/ryanodine receptor	Domain
A, B, C, D	IPR035764	Ryanodine receptor, SPRY domain 2	Domain
A, B, C, D	IPR013333	Ryanodine receptor	Family
A, B, C, D	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
A, B, C, D	IPR002048	EF-hand domain	Domain
A, B, C, D	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B, C, D	IPR003877	SPRY domain	Domain
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR001870	B30.2/SPRY domain	Domain
A, B, C, D	IPR009460	Ryanodine Receptor TM 4-6	Domain
A, B, C, D	IPR015925	Ryanodine/Inositol 1,4,5-trisphosphate receptor	Family
A, B, C, D	IPR035762	Ryanodine receptor, SPRY domain 3	Domain
A, B, C, D	IPR048581	Ryanodine receptor, junctional solenoid domain	Domain
A, B, C, D	IPR035910	RyR/IP3 receptor binding core, RIH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q15413	Pick disease primitive neuroectodermal tumor sinusitis amyotrophic lateral sclerosis breast cancer glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma oligodendroglioma pilocytic astrocytoma progressive supranuclear palsy Spasticity astrocytic tumor cystic fibrosis Pick disease primitive neuroectodermal tumor sinusitis amyotrophic lateral sclerosis breast cancer glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma oligodendroglioma pilocytic astrocytoma progressive supranuclear palsy Spasticity astrocytic tumor cystic fibrosis hyperinsulinism large cell medulloblastoma malignant hyperthermia of anesthesia osteosarcoma pituitary cancer psoriasis atypical teratoid rhabdoid tumor intellectual disability malignant colon neoplasm