9LFV | pdb_00009lfv

Crystal structure of mouse RIP3 kinase domain complexed with LK01004

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Protein kinase-like (PK-like)	8080465	3000066	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8080465	3000066	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8080465	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8080465	3000066	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Receptor-interacting serine/threonine-protein kinase 3	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity protein-containing complex binding identical protein binding protein binding	developmental process immune system development multicellular organismal process animal organ development gland development hematopoietic or lymphoid organ development multicellular organism development thymus development immune system process anatomical structure development system development lymph node development reactive oxygen species metabolic process metabolic process developmental process immune system development multicellular organismal process animal organ development gland development hematopoietic or lymphoid organ development multicellular organism development thymus development immune system process anatomical structure development system development lymph node development reactive oxygen species metabolic process metabolic process cellular process cellular component organization primary metabolic process protein metabolic process macromolecule metabolic process cellular component organization or biogenesis supramolecular fiber organization amyloid fibril formation apoptotic process cell death programmed cell death regulation of biological process response to stimulus regulation of adaptive immune response immune response regulation of response to stimulus biological regulation regulation of immune response regulation of immune system process adaptive immune response regulation of cell motility regulation of cellular process regulation of CD8-positive, alpha-beta T cell extravasation CD8-positive, alpha-beta T cell extravasation regulation of lymphocyte migration regulation of cell migration cellular extravasation regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation regulation of T cell extravasation cell migration cell motility regulation of mononuclear cell migration locomotion T cell extravasation regulation of leukocyte migration lymphocyte migration CD8-positive, alpha-beta cytotoxic T cell extravasation leukocyte migration regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration regulation of cellular extravasation regulation of biosynthetic process regulation of type II interferon production type II interferon production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process cytokine production regulation of cytokine production regulation of macromolecule biosynthetic process regulation of multicellular organismal process regulation of metabolic process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis regulation of apoptotic process regulation of programmed cell death cellular response to stimulus signaling necroptotic process programmed necrotic cell death cell communication necroptotic signaling pathway signal transduction non-canonical NF-kappaB signal transduction intracellular signal transduction intracellular signaling cassette regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of cellular process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains leukocyte mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of T cell mediated cytotoxicity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of cell killing cell killing positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation T cell differentiation leukocyte differentiation regulation of activated T cell proliferation regulation of leukocyte activation regulation of cell activation leukocyte proliferation activated T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to chemical stimulus cellular response to stress response to stress response to chemical spleen development execution phase of necroptosis positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death positive regulation of intracellular signal transduction positive regulation of apoptotic process apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling positive regulation of necroptotic process regulation of necroptotic process regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death biological process involved in interspecies interaction between organisms defense response to virus defense response response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus leukocyte apoptotic process lymphocyte apoptotic process regulation of activation-induced cell death of T cells activation-induced cell death of T cells regulation of T cell apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process T cell apoptotic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D	IPR051681	Serine/Threonine Kinases and Pseudokinases	Family
A, B, C, D	IPR000719	Protein kinase domain	Domain
A, B, C, D	IPR025735	RIP homotypic interaction motif	Binding Site
A, B, C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.