9M4W | pdb_00009m4w

Structure of human TRPC5 bound with (-)-englerin A, class 2.

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Short transient receptor potential channel 5	clathrin binding protein binding binding calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity store-operated calcium channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity clathrin binding protein binding binding calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity store-operated calcium channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding actinin binding actin binding ion binding alcohol binding inositol 1,4,5 trisphosphate binding anion binding small molecule binding ATPase binding enzyme binding	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality regulation of biological process regulation of membrane hyperpolarization membrane hyperpolarization regulation of membrane potential axon extension multicellular organismal process positive regulation of nervous system development regulation of growth regulation of cellular process axonogenesis regulation of cellular component size positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality regulation of biological process regulation of membrane hyperpolarization membrane hyperpolarization regulation of membrane potential axon extension multicellular organismal process positive regulation of nervous system development regulation of growth regulation of cellular process axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization positive regulation of developmental growth system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell growth cell morphogenesis cellular component organization regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension cellular component organization or biogenesis positive regulation of cellular process positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis negative regulation of biological process regulation of dendrite morphogenesis negative regulation of cellular component organization regulation of dendrite development negative regulation of multicellular organismal process negative regulation of neurogenesis dendrite development negative regulation of cellular process negative regulation of nervous system development negative regulation of cell differentiation negative regulation of cell projection organization negative regulation of dendrite morphogenesis negative regulation of developmental process dendrite morphogenesis negative regulation of cell development transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of neuron differentiation regulation of neuron differentiation neuron apoptotic process apoptotic process cell death programmed cell death phospholipid translocation phospholipid transport plasma membrane phospholipid scrambling execution phase of apoptosis phosphatidylserine exposure on apoptotic cell surface plasma membrane organization endomembrane system organization membrane organization lipid localization lipid transport lipid translocation regulation of membrane lipid distribution macromolecule localization organophosphate ester transport	cell periphery cellular anatomical structure plasma membrane membrane presynapse synapse cell junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex cell periphery cellular anatomical structure plasma membrane membrane presynapse synapse cell junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex growth cone axon distal axon site of polarized growth cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR002153	Transient receptor potential channel, canonical	Family
A, B, C, D	IPR013555	Transient receptor ion channel domain	Domain
A, B, C, D	IPR002110	Ankyrin repeat	Repeat
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR005461	Transient receptor potential channel, canonical 5	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9UL62	hypertensive disorder Amenorrhea Secondary to Ovarian Dysfunction endometrial carcinoma amyotrophic lateral sclerosis postmenopausal osteoporosis endometriosis medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.