9NIH | pdb_00009nih

Crystal structure of HLA-DR4 presenting citrullinated Tenascin C peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8040455	3000521	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054671	3000071	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Source
A	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	Domain
A	PF00993	Class II histocompatibility antigen, alpha domain (MHC_II_alpha)	Class II histocompatibility antigen, alpha domain	Domain
B	PF00969	Class II histocompatibility antigen, beta domain (MHC_II_beta)	Class II histocompatibility antigen, beta domain	Domain
B	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HLA class II histocompatibility antigen, DR alpha chain	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity polysaccharide binding carbohydrate binding binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity polysaccharide binding carbohydrate binding protein binding signaling receptor binding T cell receptor binding	multicellular organismal process regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion multicellular organismal process regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation CD4-positive, alpha-beta T cell activation positive regulation of leukocyte activation alpha-beta T cell activation regulation of immune system process regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of cellular process regulation of biological process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation positive regulation of alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process cellular process regulation of lymphocyte activation response to stimulus immune response positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus regulation of immune response antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen system process nervous system process cognition peptide antigen assembly with MHC class II protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class II protein complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly MHC protein complex assembly cellular component organization or biogenesis dendritic cell antigen processing and presentation myeloid dendritic cell antigen processing and presentation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity positive regulation of immune effector process positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response regulation of cell development CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response multicellular organism development cell differentiation regulation of T-helper cell differentiation anatomical structure development T cell differentiation developmental process T-helper cell differentiation leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis T cell differentiation involved in immune response regulation of hemopoiesis immunological memory formation process positive regulation of T cell differentiation positive regulation of developmental process positive regulation of memory T cell differentiation positive regulation of cell development memory T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of memory T cell differentiation immunological memory process positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of regulatory T cell differentiation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of regulatory T cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulatory T cell differentiation	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell surface MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome late endosome membrane endomembrane system late endosome lytic vacuole vacuole lysosome organelle subcompartment lumenal side of endoplasmic reticulum membrane side of membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane immunological synapse vacuolar membrane lytic vacuole membrane lysosomal membrane Golgi membrane Golgi apparatus early endosome early endosome membrane autolysosome autolysosome membrane secondary lysosome Golgi apparatus subcompartment trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane
B	HLA class II histocompatibility antigen DR beta chain	-	antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process response to stimulus immune response adaptive immune response	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle
C	Tenascin	protein binding binding syndecan binding proteoglycan binding carbohydrate derivative binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding structural molecule activity extracellular matrix structural constituent	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation developmental growth branching morphogenesis of an epithelial tube developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation developmental growth branching morphogenesis of an epithelial tube respiratory tube development multicellular organism development tube morphogenesis anatomical structure development lung morphogenesis lung development respiratory system development animal organ morphogenesis epithelial tube morphogenesis system development epithelium development axis elongation tube development branch elongation of an epithelium animal organ development growth morphogenesis of an epithelium tissue development developmental growth involved in morphogenesis tissue morphogenesis anatomical structure morphogenesis morphogenesis of a branching structure bud outgrowth involved in lung branching epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium cellular response to stimulus response to stimulus cell projection organization cell development neuron projection development regeneration response to axon injury neuron projection regeneration cellular component organization neurogenesis axon regeneration neuron differentiation cellular response to stress response to stress cellular component organization or biogenesis response to wounding peripheral nervous system axon regeneration plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development odontogenesis of dentin-containing tooth odontogenesis regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cell junction organization neuromuscular junction development synapse organization regulation of growth regulation of cellular component organization regulation of cell growth cell growth response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid response to chemical cellular response to lipid regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion response to nutrient levels response to nutrient response to vitamin cellular response to vitamin D cellular response to nutrient levels response to vitamin D cellular response to vitamin cellular response to nutrient response to alcohol response to ethanol cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to mechanical stimulus response to abiotic stimulus response to external stimulus regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response regulation of response to stimulus regulation of response to stress inflammatory response response to ketone response to prostaglandin cellular response to prostaglandin D stimulus response to endogenous stimulus cellular response to prostaglandin stimulus cellular response to endogenous stimulus cellular response to alcohol response to hormone response to prostaglandin D cellular response to ketone cellular response to hormone stimulus reproductive system development prostate gland development reproductive process gland development urogenital system development developmental process involved in reproduction prostate gland epithelium morphogenesis prostate gland morphogenesis gland morphogenesis reproductive structure development mesenchymal-epithelial cell signaling signaling mesenchymal-epithelial cell signaling involved in prostate gland development cell-cell signaling cell communication response to fibroblast growth factor response to growth factor negative regulation of cellular process negative regulation of biological process negative regulation of cell adhesion	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane basement membrane cell periphery extracellular matrix external encapsulating structure protein-containing complex protein complex involved in cell-matrix adhesion tenascin complex protein complex involved in cell adhesion cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane basement membrane cell periphery extracellular matrix external encapsulating structure protein-containing complex protein complex involved in cell-matrix adhesion tenascin complex protein complex involved in cell adhesion interstitial matrix synapse glutamatergic synapse membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region synapse-associated extracellular matrix extracellular matrix of synaptic cleft specialized extracellular matrix extracellular space perisynaptic extracellular matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
A	IPR003597	Immunoglobulin C1-set	Domain
A	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR001003	MHC class II, alpha chain, N-terminal	Domain
B	IPR000353	MHC class II, beta chain, N-terminal	Domain
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
B	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
B	IPR003597	Immunoglobulin C1-set	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
C	IPR041161	Tenascin, EGF-like domain	Domain
C	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
C	IPR000742	EGF-like domain	Domain
C	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
C	IPR003961	Fibronectin type III	Domain
C	IPR013111	Epidermal growth factor-like domain, extracellular	Domain
C	IPR050991	Extracellular Matrix Regulatory Proteins	Family
C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily
C	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P01903	toxic shock syndrome lung carcinoma multiple sclerosis juvenile dermatomyositis systemic sclerosis ulcerative colitis Parkinson disease Sjogren syndrome Crohn disease Graham Little Piccardi Lassueur syndrome pancreatic ductal adenocarcinoma Hashimoto thyroiditis pilocytic astrocytoma Hodgkins lymphoma psoriatic arthritis toxic shock syndrome lung carcinoma multiple sclerosis juvenile dermatomyositis systemic sclerosis ulcerative colitis Parkinson disease Sjogren syndrome Crohn disease Graham Little Piccardi Lassueur syndrome pancreatic ductal adenocarcinoma Hashimoto thyroiditis pilocytic astrocytoma Hodgkins lymphoma psoriatic arthritis invasive ductal breast carcinoma skin basal cell carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy systemic lupus erythematosus astrocytic tumor Becker muscular dystrophy malignant glioma celiac disease dermatomyositis neoplasm of mature B-cells Down syndrome non-alcoholic fatty liver disease esophageal adenocarcinoma osteoporosis Graham Little-Piccardi-Lassueur syndrome pancreatic intraductal papillary-mucinous carcinoma head and neck cancer primary biliary cholangitis IgA glomerulonephritis squamous cell lung carcinoma lung adenocarcinoma atopic eczema lymphoplasmacytic lymphoma breast cancer marginal zone lymphoma chronic obstructive pulmonary disease diabetes mellitus nephrotic syndrome Duchenne muscular dystrophy non-small cell lung carcinoma glioblastoma ovarian cancer Graves disease heart disease prostate carcinoma interstitial cystitis juvenile idiopathic arthritis subependymal giant cell astrocytoma alopecia areata lung cancer temporal arteritis vitiligo autism spectrum disorder malignant ependymoma breast carcinoma membranous glomerulonephritis myasthenia gravis diffuse scleroderma nodular sclerosis classical Hodgkin lymphoma osteoarthritis
C	Pharos: P24821	autosomal dominant nonsyndromic deafness 56 asthma endometriosis melanoma nonsyndromic genetic deafness varicose disease pleural disease Lung Injury juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma allergic rhinitis myopathy atopic eczema autosomal dominant nonsyndromic deafness 56 asthma endometriosis melanoma nonsyndromic genetic deafness varicose disease pleural disease Lung Injury juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma allergic rhinitis myopathy atopic eczema oligodendroglioma Becker muscular dystrophy osteosarcoma pilocytic astrocytoma congestive heart failure Sjogren syndrome Duchenne muscular dystrophy interstitial cystitis limb-girdle muscular dystrophy lung carcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma autosomal dominant nonsyndromic deafness 1 osteoarthritis ovarian cancer breast cancer cutaneous melanoma subependymal giant cell astrocytoma ductal breast carcinoma in situ interstitial lung disease lung adenocarcinoma malignant glioma astrocytic tumor osteoarthritis, hip pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cystic fibrosis ulcerative colitis Emery-Dreifuss muscular dystrophy glioblastoma