9O0U | pdb_00009o0u

Crystal structure of CRAF/MEK1 complex with PLX4720 and CH5126766

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	RAF proto-oncogene serine/threonine-protein kinase	protein serine/threonine kinase activity MAP kinase kinase kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein serine/threonine kinase activity MAP kinase kinase kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding enzyme regulator activity cyclase regulator activity enzyme activator activity cyclase activator activity molecular function activator activity molecular function regulator activity adenylate cyclase regulator activity adenylate cyclase activator activity identical protein binding protein binding protein serine kinase activity cation binding transition metal ion binding zinc ion binding metal ion binding enzyme binding	cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process signal transduction regulation of biological process regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication cellular process apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process regulation of cellular component organization negative regulation of cellular component organization protein-containing complex organization regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Rho protein signal transduction intracellular signal transduction Rho protein signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB signaling pathway ERBB3 signaling pathway biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus response to peptide response to chemical immune system process defense response to other organism cell population proliferation type B pancreatic cell proliferation epithelial cell proliferation intermediate filament-based process organelle organization cytoskeleton organization intermediate filament cytoskeleton organization developmental process multicellular organismal process somatic stem cell population maintenance maintenance of cell number stem cell population maintenance death-inducing signaling complex assembly positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription head development anatomical structure development face development immune system development animal organ development gland development hematopoietic or lymphoid organ development multicellular organism development thymus development system development thyroid gland development endocrine system development cellular developmental process peripheral nervous system development cell development nervous system development glial cell development neurogenesis Schwann cell development gliogenesis glial cell differentiation cell differentiation Schwann cell differentiation establishment of protein localization nitrogen compound transport localization carbohydrate homeostasis establishment of localization in cell regulation of biological quality intracellular protein localization regulation of hormone levels establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion establishment of localization cellular response to oxygen-containing compound cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis insulin secretion involved in cellular response to glucose stimulus cellular localization transport homeostatic process hormone secretion protein localization to extracellular region peptide secretion secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus secretion cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of signaling cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus response to endogenous stimulus cellular response to peptide hormone stimulus response to nitrogen compound response to insulin cellular response to insulin stimulus negative regulation of cell population proliferation regulation of cell population proliferation wound healing response to wounding cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway neurotrophin signaling pathway response to growth factor myelination axon ensheathment ensheathment of neurons response to mechanical stimulus response to abiotic stimulus response to muscle stretch regulation of developmental process regulation of cell differentiation	cell projection cellular anatomical structure pseudopodium plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system mitochondrial membrane cell projection cellular anatomical structure pseudopodium plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system mitochondrial membrane mitochondrion membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane cell periphery plasma membrane nucleus
B, D, F, H	Dual specificity mitogen-activated protein kinase kinase 1	small GTPase binding protein binding binding enzyme binding GTPase binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding small GTPase binding protein binding binding enzyme binding GTPase binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity MAP-kinase scaffold activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity kinase binding mitogen-activated protein kinase kinase kinase binding protein kinase binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity scaffold protein binding protein serine kinase activity protein serine/threonine kinase activity	response to stimulus response to stress response to wounding response to axon injury developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development placenta development chordate embryonic development response to stimulus response to stress response to wounding response to axon injury developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development placenta development chordate embryonic development labyrinthine layer development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process chemical homeostasis homeostatic process triglyceride homeostasis acylglycerol homeostasis lipid homeostasis positive regulation of nervous system development axonogenesis cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation positive regulation of cell projection organization regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization cellular response to stimulus cell surface receptor signaling pathway signaling insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway placenta blood vessel development vasculature development blood vessel development Golgi inheritance organelle inheritance regulation of organelle organization regulation of Golgi organization organelle organization regulation of Golgi inheritance Golgi organization endomembrane system organization cellular response to stress cellular senescence intracellular signal transduction intracellular signaling cassette MAPK cascade chemotaxis taxis response to chemical response to external stimulus locomotion ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB signaling pathway ERBB3 signaling pathway cell population proliferation type B pancreatic cell proliferation epithelial cell proliferation negative regulation of homotypic cell-cell adhesion regulation of homotypic cell-cell adhesion regulation of cell adhesion negative regulation of biological process homotypic cell-cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion vesicle localization establishment of organelle localization cellular localization transport establishment of melanosome localization establishment of vesicle localization cellular pigmentation pigment granule transport establishment of pigment granule localization establishment of localization localization pigmentation pigment granule localization organelle localization establishment of localization in cell melanosome transport melanosome localization regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process cerebellum morphogenesis cerebellar cortex morphogenesis head development hindbrain morphogenesis brain development cerebellar cortex development cerebellum development central nervous system development metencephalon development anatomical structure formation involved in morphogenesis cerebellar cortex formation hindbrain development nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of ATP metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process regulation of small molecule metabolic process positive regulation of purine nucleotide biosynthetic process regulation of nucleotide metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine-containing compound biosynthetic process purine nucleoside triphosphate metabolic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process organophosphate metabolic process positive regulation of small molecule metabolic process vascular associated smooth muscle contraction system process regulation of vascular associated smooth muscle contraction regulation of system process circulatory system process smooth muscle contraction regulation of smooth muscle contraction blood vessel diameter maintenance regulation of biological quality blood circulation regulation of tube diameter regulation of tube size muscle contraction muscle system process regulation of muscle system process regulation of blood circulation regulation of muscle contraction vascular process in circulatory system regulation of vasoconstriction vasoconstriction regulation of anatomical structure size cell motility positive regulation of autophagy catabolic process autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process process utilizing autophagic mechanism face development epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation cellular response to oxygen levels cellular response to hypoxia regulation of cellular response to stress regulation of signal transduction regulation of programmed cell death negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway response to decreased oxygen levels negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of apoptotic process intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia regulation of response to stimulus response to oxygen levels response to abiotic stimulus regulation of apoptotic signaling pathway regulation of cellular response to hypoxia negative regulation of signaling negative regulation of intracellular signal transduction cellular response to decreased oxygen levels regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication regulation of intracellular signal transduction regulation of response to stress regulation of signaling negative regulation of response to stimulus regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of signal transduction negative regulation of cellular response to hypoxia apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway cellular response to chemical stimulus negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway regulation of cell communication apoptotic process programmed cell death immune system development gland development hematopoietic or lymphoid organ development thymus development immune system process positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling thyroid gland development endocrine system development vesicle cytoskeletal trafficking organelle transport along microtubule intracellular transport vesicle transport along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process formation of primary germ layer embryonic morphogenesis gastrulation endoderm development endoderm formation endodermal cell differentiation peripheral nervous system development glial cell development Schwann cell development gliogenesis glial cell differentiation Schwann cell differentiation central nervous system neuron differentiation positive regulation of muscle contraction stress-activated MAPK cascade regulation of stress-activated protein kinase signaling cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade response to corticosteroid response to lipid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid trachea morphogenesis trachea formation trachea development respiratory system development animal organ formation animal organ morphogenesis regulation of localization regulation of transport regulation of vesicle-mediated transport vesicle-mediated transport endosomal transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport regulation of cellular localization regulation of intracellular transport astrocyte differentiation Bergmann glial cell differentiation protein localization to synapse regulation of protein localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane intracellular protein localization regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels macromolecule localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse negative regulation of cell population proliferation regulation of cell population proliferation regulation of endodermal cell differentiation positive regulation of endodermal cell differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription myelination axon ensheathment ensheathment of neurons transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II transcription by RNA polymerase II positive regulation of DNA-templated transcription, elongation regulation of transcription by RNA polymerase II regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II positive regulation of transcription by RNA polymerase II DNA-templated transcription elongation negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process response to oxidative stress regulation of response to external stimulus regeneration neuron projection regeneration regulation of response to wounding axon regeneration regulation of axon regeneration regulation of neuron projection regeneration small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of small GTPase mediated signal transduction tube development respiratory tube development lung epithelium development epithelial cell proliferation involved in lung morphogenesis lung development lung morphogenesis	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular organelle Golgi apparatus somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm axon cell projection neuron projection plasma membrane bounded cell projection intracellular membraneless organelle cilium ciliary basal body microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex mitochondrion anchoring junction focal adhesion cell-substrate junction cell periphery cell cortex centrosome plasma membrane membrane neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm dendrite dendritic tree early endosome endosome intracellular vesicle cytoplasmic vesicle vesicle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse late endosome nucleus endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR003116	Raf-like Ras-binding	Domain
A, C, E, G	IPR020454	Diacylglycerol/phorbol-ester binding	Domain
A, C, E, G	IPR000719	Protein kinase domain	Domain
A, C, E, G	IPR017441	Protein kinase, ATP binding site	Binding Site
A, C, E, G	IPR051681	Serine/Threonine Kinases and Pseudokinases	Family
A, C, E, G	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A, C, E, G	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C, E, G	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A, C, E, G	IPR046349	C1-like domain superfamily	Homologous Superfamily
A, C, E, G	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B, D, F, H	IPR000719	Protein kinase domain	Domain
B, D, F, H	IPR050915	MAP kinase kinase	Family
B, D, F, H	IPR017441	Protein kinase, ATP binding site	Binding Site
B, D, F, H	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D, F, H	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: P04049	Noonan syndrome with multiple lentigines Noonan syndrome Noonan syndrome 5 LEOPARD syndrome 2 dilated cardiomyopathy 1NN hypertrophic cardiomyopathy malignant glioma dilated cardiomyopathy pilocytic astrocytoma mixed glioma non-small cell lung carcinoma Hyperalgesia liver cancer breast carcinoma malignant mesothelioma Noonan syndrome with multiple lentigines Noonan syndrome Noonan syndrome 5 LEOPARD syndrome 2 dilated cardiomyopathy 1NN hypertrophic cardiomyopathy malignant glioma dilated cardiomyopathy pilocytic astrocytoma mixed glioma non-small cell lung carcinoma Hyperalgesia liver cancer breast carcinoma malignant mesothelioma cancer cardiomyopathy hydrops fetalis osteogenesis imperfecta intellectual disability lung adenocarcinoma urinary bladder cancer malignant ependymoma breast cancer Charcot-Marie-Tooth disease medulloblastoma dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy glioma ovarian cancer kidney cancer plasma cell myeloma lung benign neoplasm astrocytic tumor cutaneous melanoma melanoma neurofibromatosis type 1 hepatocellular carcinoma oligodendroglioma ovarian serous adenocarcinoma kidney neoplasm renal cell carcinoma liver neoplasm familial dilated cardiomyopathy non-alcoholic fatty liver disease glioblastoma
B, D, F, H	Pharos: Q02750	cardiofaciocutaneous syndrome Noonan syndrome Costello syndrome hairy cell leukemia melanoma cardiofaciocutaneous syndrome 3 intellectual disability cardiomyopathy brain ischemia neurofibromatosis type 1 cancer cutaneous melanoma prostate carcinoma testicular germ cell tumor lung adenocarcinoma cardiofaciocutaneous syndrome Noonan syndrome Costello syndrome hairy cell leukemia melanoma cardiofaciocutaneous syndrome 3 intellectual disability cardiomyopathy brain ischemia neurofibromatosis type 1 cancer cutaneous melanoma prostate carcinoma testicular germ cell tumor lung adenocarcinoma Unresectable malignant melanoma with BRAF gene mutation malignant ependymoma melorheostosis colorectal adenocarcinoma oligodendroglioma ovarian neoplasm primitive neuroectodermal tumor hydrops fetalis Langerhans cell histiocytosis lung cancer astrocytic tumor medulloblastoma cardiofaciocutaneous syndrome 1 Noonan syndrome 1 ovarian cancer dermatomyositis Pick disease glioblastoma hypertrophic cardiomyopathy subependymal giant cell astrocytoma large cell medulloblastoma major depressive disorder atypical teratoid rhabdoid tumor non-small cell lung carcinoma Charcot-Marie-Tooth disease Noonan syndrome with multiple lentigines ovarian carcinoma plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.