9R3J | pdb_00009r3j

Crystal structure of human MAO B in complex with (E)-3-(benzo[d][1,3]dioxol-5-yl)-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one (chalcone inhibitor, 4e)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB]	PF01593	Flavin containing amine oxidoreductase (Amino_oxidase)	Flavin containing amine oxidoreductase	This family consists of various amine oxidases, including maze polyamine oxidase (PAO) [1] and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene ...	This family consists of various amine oxidases, including maze polyamine oxidase (PAO) [1] and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines [2]. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium [3]. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines [1]. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB]	Amine oxidase [flavin-containing] B	monoamine oxidase activity oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding small molecule binding primary methylamine oxidase activity monoamine oxidase activity oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding small molecule binding primary methylamine oxidase activity electron transfer activity	developmental process multicellular organismal process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development anatomical structure development neural nucleus development system development reactive oxygen species biosynthetic process developmental process multicellular organismal process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development anatomical structure development neural nucleus development system development reactive oxygen species biosynthetic process biosynthetic process reactive oxygen species metabolic process hydrogen peroxide metabolic process metabolic process cellular process hydrogen peroxide biosynthetic process catecholamine catabolic process catabolic process catechol-containing compound catabolic process dopamine metabolic process catechol-containing compound metabolic process biogenic amine catabolic process phenol-containing compound catabolic process amine metabolic process dopamine catabolic process catecholamine metabolic process phenol-containing compound metabolic process biogenic amine metabolic process amine catabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope mitochondrial envelope mitochondrial membrane membrane organelle outer membrane bounding membrane of organelle membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope mitochondrial envelope mitochondrial membrane membrane organelle outer membrane bounding membrane of organelle mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB]	IPR002937	Amine oxidase	Domain
A [auth AAA], B [auth BBB]	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR050703	Flavin Monoamine Oxidase	Family
A [auth AAA], B [auth BBB]	IPR001613	Flavin amine oxidase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA], B [auth BBB]	Pharos: P27338	Alzheimer disease Parkinson disease Huntington disease malignant colon neoplasm megaloblastic anemia hepatic encephalopathy major depressive disorder hepatic coma endometriosis Pheochromocytoma schizophrenia depressive disorder extra-adrenal sympathetic paraganglioma pilocytic astrocytoma head and neck cancer Alzheimer disease Parkinson disease Huntington disease malignant colon neoplasm megaloblastic anemia hepatic encephalopathy major depressive disorder hepatic coma endometriosis Pheochromocytoma schizophrenia depressive disorder extra-adrenal sympathetic paraganglioma pilocytic astrocytoma head and neck cancer hypertensive disorder intellectual disability large cell medulloblastoma autism medulloblastoma bipolar disorder colonic neoplasm pancreatic ductal adenocarcinoma phaeochromocytoma pituitary cancer psoriasis sinusitis adrenal gland pheochromocytoma invasive ductal breast carcinoma lung adenocarcinoma breast cancer non-small cell lung carcinoma cystic fibrosis toxic encephalopathy hypotensive disorder juvenile Huntington disease lung cancer atypical teratoid rhabdoid tumor malignant ependymoma benign colon neoplasm breast carcinoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.