9RUR | pdb_00009rur

Structure of WRN in complex with ATPgS and covalent ligand Compound 4d

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity telomeric G-quadruplex DNA binding DNA binding sequence-specific DNA binding G-quadruplex DNA binding nucleic acid binding telomeric DNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding hydrolase activity, acting on ester bonds nuclease activity 3'-5' exonuclease activity hydrolase activity exonuclease activity protein-containing complex binding DNA secondary structure binding four-way junction DNA binding 3'-5' DNA helicase activity bubble DNA binding Y-form DNA binding mismatch repair complex binding MutLalpha complex binding magnesium ion binding flap-structured DNA binding 3'-flap-structured DNA binding identical protein binding protein binding protein homodimerization activity protein dimerization activity oxidized DNA binding oxidized purine DNA binding damaged DNA binding 8-hydroxy-2'-deoxyguanosine DNA binding telomeric D-loop binding D-loop DNA binding four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process macromolecule metabolic process replication fork processing cellular component organization organelle organization DNA geometric change chromosome organization DNA conformation change cellular component organization or biogenesis mismatch repair DNA repair replicative senescence cell cycle cell cycle process formation of extrachromosomal circular DNA telomere organization cellular component biogenesis telomere maintenance cellular component assembly telomere maintenance via telomere trimming t-circle formation cellular senescence regulation of cellular process positive regulation of strand invasion positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of strand invasion positive regulation of cellular process regulation of biological process positive regulation of nucleobase-containing compound metabolic process DNA recombination biological regulation regulation of macromolecule metabolic process DNA strand invasion positive regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to starvation base-excision repair cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation localization protein localization to nucleolus protein localization to organelle macromolecule localization protein localization to nucleus intracellular protein localization telomeric loop disassembly telomeric D-loop disassembly multicellular organismal process determination of adult lifespan double-strand break repair recombinational repair double-strand break repair via homologous recombination nuclear DNA replication cell cycle DNA replication telomere maintenance via semi-conservative replication response to oxidative stress nucleobase-containing compound biosynthetic process DNA synthesis involved in DNA repair macromolecule biosynthetic process nucleic acid biosynthetic process biosynthetic process DNA biosynthetic process response to light stimulus response to UV-C response to UV positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of growth growth regulation of growth rate	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck ribonucleoprotein granule intracellular organelle nuclear body cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck ribonucleoprotein granule intracellular organelle nuclear body cellular anatomical structure nucleoplasm organelle lumen organelle membraneless organelle supramolecular complex nuclear ribonucleoprotein granule nuclear lumen cytoplasm chromosome chromosome, telomeric region chromosomal region nucleolus centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton replication fork

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
A, B	IPR002121	HRDC domain	Domain
A, B	IPR011545	DEAD/DEAH-box helicase domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR010997	HRDC-like superfamily	Homologous Superfamily
A, B	IPR001650	Helicase, C-terminal domain-like	Domain
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR029491	Helicase Helix-turn-helix domain	Domain
A, B	IPR004589	DNA helicase, ATP-dependent, RecQ type	Family
A, B	IPR032284	ATP-dependent DNA helicase RecQ, zinc-binding domain	Domain
A, B	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
A, B	IPR002562	3'-5' exonuclease domain	Domain
A, B	IPR018982	RQC domain	Domain
A, B	IPR044876	HRDC domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14191	Werner syndrome colorectal cancer osteosarcoma premature aging syndrome thyroid gland carcinoma Bloom syndrome Hutchinson-Gilford progeria syndrome lung cancer metabolic syndrome X peripheral nervous system disease prostate cancer cancer diabetes mellitus intellectual disability medulloblastoma Werner syndrome colorectal cancer osteosarcoma premature aging syndrome thyroid gland carcinoma Bloom syndrome Hutchinson-Gilford progeria syndrome lung cancer metabolic syndrome X peripheral nervous system disease prostate cancer cancer diabetes mellitus intellectual disability medulloblastoma osteogenesis imperfecta peripheral neuropathy psoriasis cataract DNA repair disease large cell medulloblastoma meningioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.