Annotations: 9YMG

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, F	Kinesin-like protein KIF18A, DARPin fusion protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding tubulin-dependent ATPase activity ATP-dependent activity actin binding plus-end-directed microtubule motor activity microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides microtubule plus-end binding	developmental process multicellular organismal process reproductive system development gonad development tube development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics seminiferous tubule development developmental process multicellular organismal process reproductive system development gonad development tube development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics seminiferous tubule development anatomical structure development reproductive structure development system development localization establishment of protein localization nitrogen compound transport protein transport transport macromolecule localization intracellular protein localization establishment of localization mitotic nuclear division mitotic metaphase chromosome alignment organelle fission chromosome organization sister chromatid segregation mitotic cell cycle metaphase chromosome alignment cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome localization organelle localization nuclear chromosome segregation mitotic sister chromatid segregation cellular process cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process sexual reproduction meiotic cell cycle male meiotic nuclear division multicellular organismal reproductive process meiotic cell cycle process male gamete generation gamete generation meiotic nuclear division cellular component disassembly protein-containing complex organization microtubule cytoskeleton organization protein-containing complex disassembly microtubule polymerization or depolymerization microtubule depolymerization microtubule-based process supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of microtubule-based process regulation of organelle organization regulation of microtubule cytoskeleton organization microtubule-based movement cellular response to stimulus response to lipid response to stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid response to estradiol cellular response to estradiol stimulus	polymeric cytoskeletal fiber intracellular anatomical structure mitotic spindle spindle aster mitotic spindle astral microtubule intracellular membraneless organelle astral microtubule spindle microtubule cytoplasmic microtubule intracellular organelle cellular anatomical structure cytoskeleton organelle polymeric cytoskeletal fiber intracellular anatomical structure mitotic spindle spindle aster mitotic spindle astral microtubule intracellular membraneless organelle astral microtubule spindle microtubule cytoplasmic microtubule intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle supramolecular fiber cytoplasm microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton centrosome microtubule organizing center cytosol membrane microdomain cell periphery membrane raft plasma membrane raft membrane plasma membrane plasma membrane region caveola protein-containing complex microtubule associated complex kinesin complex kinetochore microtubule chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome ruffle cell projection cell leading edge plasma membrane bounded cell projection mitotic spindle midzone spindle midzone membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B, E	Tubulin beta chain	structural constituent of cytoskeleton structural molecule activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding structural constituent of cytoskeleton structural molecule activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization developmental process multicellular organismal process neuron migration cellular developmental process nervous system development cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization developmental process multicellular organismal process neuron migration cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation anatomical structure development cell migration cell motility system development	cellular anatomical structure intracellular anatomical structure cytoplasm polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
A, D	Tubulin alpha-1B chain	structural constituent of cytoskeleton structural molecule activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding structural constituent of cytoskeleton structural molecule activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization	cellular anatomical structure intracellular anatomical structure cytoplasm polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, F	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
C, F	IPR001752	Kinesin motor domain	Domain
C, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, F	IPR027640	Kinesin-like protein	Family
C, F	IPR019821	Kinesin motor domain, conserved site	Conserved Site
B, E	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
B, E	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
B, E	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
B, E	IPR017975	Tubulin, conserved site	Conserved Site
B, E	IPR000217	Tubulin	Family
B, E	IPR023123	Tubulin, C-terminal	Homologous Superfamily
B, E	IPR002453	Beta tubulin	Family
B, E	IPR013838	Beta tubulin, autoregulation binding site	Binding Site
B, E	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
B, E	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
A, D	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
A, D	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
A, D	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
A, D	IPR017975	Tubulin, conserved site	Conserved Site
A, D	IPR002452	Alpha tubulin	Family
A, D	IPR000217	Tubulin	Family
A, D	IPR023123	Tubulin, C-terminal	Homologous Superfamily
A, D	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
A, D	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, F	Pharos: Q8NI77	adrenal cortex carcinoma breast cancer hepatocellular carcinoma lung cancer malignant glioma non-small cell lung carcinoma psoriasis atopic eczema Crohn disease IgA glomerulonephritis malignant colon neoplasm medulloblastoma ovarian cancer atypical teratoid rhabdoid tumor glioblastoma adrenal cortex carcinoma breast cancer hepatocellular carcinoma lung cancer malignant glioma non-small cell lung carcinoma psoriasis atopic eczema Crohn disease IgA glomerulonephritis malignant colon neoplasm medulloblastoma ovarian cancer atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant ependymoma nasopharyngeal carcinoma primitive neuroectodermal tumor