Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability.[A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.[A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]
Synonyms
17-ethinyl-3,17-estradiol
17α-ethynylestradiol
17alpha-Ethinyl estradiol
17-ethinylestradiol
Ethinyl estradiol
Ethinylestradiolum
17-ethinyl-3,17-oestradiol
Ethynyl estradiol
Ethinyloestradiol
Etinilestradiol
Ethinylestradiol
Brand Names
Hailey 24 Fe
Aviane 28
Levonorgestrel and Ethinyl Estradoil
Tri-cira Lo 21
Modicon
Cyclessa
Tri-Norinyl
Nortrel (21 Day Regimen)
Gemmily
Femynor
Estarylla
Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium
Ovima 28
Tri-cyclen Lo (28 Day)
Tri-Linyah
LOESTRIN Fe 1/20
Altavera
Tri-cyclen Tablets - 21-day
MonoNessa
Previfem (28day)
Kalliga
Esme 28
Min-ovral 28 Tab
Ortho 1/35 Tablets (28 Day)
Apri 21
Tarina 24 Fe
Gildagia
Kimidess
Centrisa 21
Mircette
Loestrin 1.5/30
Drospirenone and Ethinyl Estradiol Tablets USP
Lolo
Tri-jordyna 28
camrese Lo
Minzoya
Etonogestrel and Ethinyl Estradiol
Larin 1.5/30
Ortho 7/7/7 Tablets (28 Day)
Tri-previfem (21 Day)
Alysena 21
Dasetta 1/35
Delyla
Ortho-Novum 777
Tri-cyclen Lo (21 Day)
Zenchent
Cyclafem 1/35
Triphasil-21
Nuvaring
Min-ovral 21
Amethia
Junel Fe 1/20
Zumandimine
EluRyng
Zafemy
Tri-lena Lo 21
Synphasic-28 Tablets
Microgestin 24 Fe
Aurovela Fe 1/20
Melodetta 24 Fe
Bekyree
Wera
Tyblume
Merzee
Emoquette
Aurovela 1.5/30
Aviane 28 Day
Yasmin 21
Ovral 21
Zarah 21
Linessa 21
Yasmin
Loestrin 21 1/20
Freya 21
Zovia 1/50E-28
Levlite
Brevicon 0.5/35 28 Tab
Lutera
Cryselle
Tri-previfem (28 Day)
Enskyce
Etonogestrel and Ethinyl Estradiol Vaginal Ring
Joyeaux
Tri-Lo- Estarylla
Blisovi Fe 1/20
Enpresse
Brevicon 0.5/35 Tablets (28-day Pack)
Tri-VyLibra Lo
Ovral 28tab
Larin Fe 1.5/30
Ortho Tri Cyclen
Levonorgestrel and Ethinyl Estradiol
Nortrel 21 Day
Select 1/35 (21-day)
Necon 0.5/35
Estinyl Tab 0.5mg
Juleber
Necon 777 777
Cyonanz
Pimtrea
Balcoltra
Reclipsen
FEMCON Fe
Wymzya Fe
Ortho 0.5/35 Tablets (28 Day)
Ocella
Ovral 21 Tab
Zeosa
Lybrel
Junel 1.5/30
Mya
Kaitlib Fe
Gildess 1.5/30
Demulen 30 (21 Day Pack)
Ethynodiol Diacetate and Ethinyl Estradiol
Gildess 1/20
Blisovi 24 Fe
Minestrin 1/20
Cesia
Alesse 21
Junel Fe 28 Day
Tri-jordyna 21
Tri-Mili
Ortho 7/7/7 Tablets (21 Day)
Brevicon 1/35 Tablets (28-day Pack)
Drospirenone and ethinyl estradiol
Ortho Cyclen
Mercilon
Nortrel 7/7/7 (28 Day Regimen)
Centrisa Lo 21
Chateal EQ
Nexesta Fe
Annovera
Norethindrone and Ethinyl Estradiol and Ferrous Fumarate
Myzilra
Microgestin
Haloette
Lo-Zumandimine
Portia 28
Teva-cyproterone / Ethinyl Estradiol
Brevicon 0.5/35 21 Tab
Larissia
Tri-cyclen Tablets - 28-day
Quaterna
Dolishale
Portia 21
Drospirenone and Ethinyl estradiol
Seasonale
Cyclafem 7/7/7
Alyacen 7/7/7
Brevicon 1/35 28 Tab
Lo/Ovral
Solia
Norgestrel/Ethinyl Estradiol
Tri-Legest Fe 28 Day
Levonest
Pirmella 7/7/7
Demulen 50 (21 Day Pack)
Jinteli
Laylaa 21
Amethyst
Loestrin 24 Fe
Aviane 21
AUROVELA Fe
Quartette
Drospirenone and Ethinyl Estradiol Tablets 28
Vyfemla
Setlakin
Norelgestromin and Ethinyl Estradiol
Oshih
Junel 21 Day
Fayosim
Necon 777
Microgestin 1/20
Finzala
Zamine 21
Camrese
Cyclen Tablets (28 Day)
Fyavolv
Junel Fe 1.5/30
Triphasil 28
Cléo -35
Generess
Charlotte 24Fe
Zenchent 0.4/35
Triphasil 21 Tab
Jolessa
Drospirenone and Ethinyl Estradiol
Mibelas 24 Fe
Norethindrone and Ethinyl Estradiol, and Ferrous Fumarate
Tri-Estarylla
Nymyo
Leena
Etonogestrel/Ethinyl Estradiol
Ortho Novum 1/35
Minastrin 24 Fe
Lo/ovral-28
WYMZYA Fe
Tri-Nymyo
Norethindrone acetate and ethinyl estradiol, and ferrous fumarate
Norgestimate and Ethinyl Estradiol
Norinyl
Azurette
Triquilar 21
Larin 1/20
Marvelon 21
Tri-Lo-Mili
Ortho Tri-Cyclen
Drospirenone and Ethinyl Estradiol Tablets
Evra -(6/0.75)
Taytulla
Cyred EQ
Tri-Sprintec
Femlyv
Low-Ogestrel
Min-ovral 28
Pirmella 1/35
LOESTRIN Fe 1.5/30
Hailey 1.5/30
Etonogestrel and Ethinyl Estradiol Vaginal
Xulane
Jaimiess
Alesse 28
VyLibra
Nylia 7/7/7
Daysee
Kariva
Tri-Lo-Sprintec
Estinyl Tablets 0.02 Mg.
Qismette 21
Drospirenone and Ethinyl Estradiol Tablets 21
Loestrin 21 1.5/30
Minivlar 30
Alysena 28
Marvelon 28
Norelgestromin and Ethinly Estradiol
Ortho 10/11 Tablets (21 Day)
Reclipsen 21
Select 1/35 (28-day)
Zenchent FE
Apri 28 Day
Ortho Cept
Reclipsen 28
Viorele
Seasonique
Brevicon 1/35 Tablets (21-day Pack)
Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol
Tri-cira 21
Vestura
Desogestrel/Ethinyl Estradiol and Ethinyl Estradiol
Norethindrone Acetate and Ethinyl Estradiol
ESTROSTEP Fe
Centrisa 28
Iclevia
Necon 1/35 (28 Day Regimen)
LOESTRIN 1.5/30 21 Day
Taysofy
Ovcon 35
Desogen
Necon (28 Day Regimen)
Ortho 10/11 Tablets (28 Day)
Zamine 28
EnilloRing
Quasense
Drospirenone and Ethinyl Estradiol Tablets USP 21
Rajani
Levonorgetsrel and Ethinyl Estradiol
Norethindrone and ethinyl estradiol
Audrina 21
Necon 10/11
Mirvala 21
Min-ovral 21 Tab
Levora
Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol
Aranelle
Falmina
Reclipsen 28 Day
Norethindrone and ethinyl estradiol and ferrous fumarate
Ortho Novum 135
Alyacen 1/35
Falessa
Drospirenone, Ethinyl Estradiol and Levomefolate Calcium and Levomefolate Calcium
Triphasil 21
Tarina Fe 1/20 EQ
Apri
Aurovela 24 Fe
Nortrel 28 Day
Yaz
Norethindrone Acetate and Ethinyl Estradiol, and Ferrous Fumarate
Ashlyna
LOESTRIN Fe 1/20 28 Day
Briellyn
Junel FE
Junel Fe 24
Larin Fe 1/20
Sarensis 28
Demulen 50 (28 Day Pack)
Twirla
Gildess Fe 1.5/30
Larin 24 Fe
Zarah
Marfem 28
Ortho-cept Tablets (21 Day)
Introvale
Previfem (21day)
Isibloom
Vienva TM
Caziant
Ayuna
Mili
Kurvelo
Evra
Loestrin Fe 28 Day
Freya 28
Caziant Triphasic Regimen
Triquilar 28
Taro-cyproterone/ethinyl Estradiol
Mono-Linyah
Lo Simpesse
Lillow
Nylia 1/35
Portia
Safyral
Sronyx
Mono-linyah
Jevantique
MICROGESTIN Fe 1/20
Norethindrone Acetate and Ethinyl Estradiol and Ferrous Fumarate
Zovia 1/35
Microgestin Fe
Lo-femenal 21 Tablets
Mylan-cyproterone / Ethinylestradiol
Sprintec
Kelnor 1/35
Rivelsa
Velivet Triphasic Regimen
Dasetta 7/7/7
Jasmiel
Beyaz
TARINA Fe 1/20
Cyred
Vienva
Gildess Fe 1/20
Nordette
Brevicon
Ortho 0.5/35 Tablets (21 Day)
Tri-VyLibra
Microgestin Fe 1.5/30
Qismette 28
Ovral 28 Tablets
Preven Emergency Contraceptive
Zovia 1/35E-28
Sarensis 21
Trivora
Lessina
Diane-35
Afirmelle
Rhuzdah
ORTHO TRI CYCLEN Lo
NuvaRing
Elinest
Triphasil 28 Tab
Lo-ovral-28
Indayo
Audrina 28
Tri Femynor
Ortho-novum 10/11
Myvlar
Microgestin Fe 1/20
Synphasic 28 Tablets
Marfem 21
Necon 1/35
Orsythia
Femhrt
Lutera 28
Zarah 28
Esme 21
Chateal
Tri-cira 28
Tri-lena 21
LoSeasonique
TriNessa
Yasmin Plus
Mirvala 28
Tri-LO-marzia
Tri-lena 28
Tri-Previfem
Simliya
Lo Minastrin Fe
LOESTRIN 1/20 21 Day
Tilia Fe
Ovima 21
Loryna
Marlissa
Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium
Volnea
Hailey Fe 1.5/30
Linessa 28
Lomedia 24 Fe
Kelnor 1/50
LOESTRIN Fe 1.5/30 28 Day
Nikki
Yasmin 28
LoJaimiess
Ortho 1/35 Tablets (21 Day)
Yaz Plus
Cyclen Tablets (21 Day)
Cyestra-35
Lo Loestrin Fe
TriNessa Lo
Turqoz
Demulen 30 (28 Day Pack)
Ogestrel
Philith
Tydemy
Laylaa 28
Estinyl Tab 0.05mg
Apri 28
Ovcon 50
Gildess 24 Fe
Tri-lena Lo 28
Lo/Ovral-28
Lutera 21
Brevicon 1/35 21 Tab
Previfem
Aviane
Synphasic 21 Tablets
HAILEY Fe 1/20
Desogestrel and Ethinyl Estradiol
Amethia Lo
Necon
Microgestin 1.5/30
Gianvi
Layolis Fe
Simpesse
Aurovela 1/20
Tri-cira Lo 28
Centrisa Lo 28
Aubra
Ortho Evra
Blisovi Fe 1.5/30
Norgestimate and ethinyl estradiol
Loestrin 21 Day
GENERESS Fe
Jevantique Lo
Ortho-cept Tablets (28 Day)
Balziva
Vienva Tm
Aubra EQ
Drospirenone and Ethinyl Estradiol Tablets USP 28
Syeda
Brevicon 0.5/35 Tablets (21-day Pack)
Preven Tablets
MICROGESTIN Fe 1.5/30
Indication
Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis.[L11944,L11965,L11947,L11950,L11845,L9806,L11953,L10304,L11956,L11959,L11962]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682