7OQ

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-oxidanylphenoxy)oxane-3,4,5-triol

Created:2021-10-08
Last modified:  2022-03-09

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Chemical Details

Formal Charge0
Atom Count35
Chiral Atom Count5
Bond Count36
Aromatic Bond Count6
2D diagram of 7OQ
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Chemical Component Summary

Name(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-oxidanylphenoxy)oxane-3,4,5-triol
Systematic Name (OpenEye OEToolkits)(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-(4-oxidanylphenoxy)oxane-3,4,5-triol
FormulaC12 H16 O7
Molecular Weight272.251
TypeNON-POLYMER

Chemical Descriptors

TypeProgramVersionDescriptor
SMILESCACTVS3.385OC[CH]1O[CH](Oc2ccc(O)cc2)[CH](O)[CH](O)[CH]1O
SMILESOpenEye OEToolkits2.0.7c1cc(ccc1O)OC2C(C(C(C(O2)CO)O)O)O
Canonical SMILESCACTVS3.385 OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Canonical SMILESOpenEye OEToolkits2.0.7 c1cc(ccc1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
InChIInChI1.03 InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
InChIKeyInChI1.03 BJRNKVDFDLYUGJ-RMPHRYRLSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License
DrugBank IDDB11217 
NameArbutin
Groups approved
DescriptionExtracted from the dried leaves of bearberry plant in the genus _Arctostaphylos_ and other plants commonly in the _Ericaceae_ family, arbutin is a beta-D-glucopyranoside of [DB09526]. It is found in foods, over-the-counter drugs, and herbal dietary supplements [F43]. Most commonly, it is an active ingredient in skincare and cosmetic products as a skin-lightening agent for the prevention of melanin formation in various skin conditions that involve cutaneous hyperpigmentation or hyperactive melanocyte function [A27248]. It has also been used as an anti-infective for the urinary system as well as a diuretic [F43]. Arbutin is available in both natural and synthetic forms; it can be synthesized from acetobromglucose and [DB09526] [F43]. Arbutin is a competitive inhibitor of tyrosinase (E.C.1.14.18.1) in melanocytes [A27248], and the inhibition of melanin synthesis at non-toxic concentrations was observed _in vitro_. Arbutin was shown to be less cytotoxic to melanocytes in culture compared to [DB09526] [A32942].
Synonyms
  • Arbutin
  • p-hydroxyphenyl β-D-glucopyranoside
  • Hydroquinone-O-beta-D-glucopyranoside
  • p-hydroxyphenyl β-D-glucoside
  • beta-Arbutin
Brand Names
  • Dr G Whitening FORTIFIER by EGF
  • Cathycat Chewy CREAM FOUNDATION SPF23 PA WHITENING ANTI WRINKLE 23
  • IASO White Science EX Emulsion
  • The Prestige BB SPF25 PA 2Plus
  • Suyan Jeongbaek
IndicationIndicated for over-the-counter use for epidermal hyperpigmentation in various skin conditions, such as melasma, freckles, and senile lentigines.
Categories
  • Carbohydrates
  • Glucosides
  • Glycosides
CAS number497-76-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License
NameTarget SequencePharmacological ActionActions
TyrosinaseMLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLS...unknowninhibitor
AlbuminMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 440936
ChEMBL CHEMBL232202
ChEBI CHEBI:18305
CCDC/CSD FUYJOZ, MIDSAW
COD 7246331, 7246329, 7246330