Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885]
Synonyms
Rispéridone
Risperidone
Risperidona
Risperidonum
Risperidone tartrate
Brand Names
Sandoz Risperidone
Perseris
Okedi
Ratio-risperidone
Risperidone - 4
Ava-risperidone
Jamp-risperidone
Riva-risperidone
Mylan-risperidone ODT
Truemed Group LLC
Risperdal M-tab
Ipg-risperidone
Risperdal Oral Solution
Pro-risperidone
Uzedy
Q-risperidone
Mylan-risperidone
Risvan
Act Risperidone
Dom-risperidone ODT
Teva-risperidone
Risperidone - 1
Risperdal
PMS-risperidone
Risperidone - 3
Risperidone - 2
Ag-risperidone
Mar-risperidone
Risperidone M-TAB
Risperidone
Risperidone - 0.5
Risperdal Consta
Rykindo extended-release microspheres
PHL-risperidone
PMS-risperidone ODT
Ran-risperidone
Dom-risperidone
Risperidone - 0.25
Risperidone Tablets
Taro-risperidone
PHL-risperidone ODT
Mint-risperidon
Nu-risperidone
Apo-risperidone
Indication
Risperidone is indicated for the treatment of schizophrenia [L12885,L44692,L46297] and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885,L44692] Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906] Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
