Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.[L31883] It was first patented in 1957[A230108] and received its initial US approval in 1986.[L31858]
Synonyms
Tranhexamic acid
Tranexamic acid
Acidum tranexamicum
ácido tranexámico
Tranexmic acid
Tranexamsaeure
trans-Amcha
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
Acide tranéxamique
Trans AMCHA
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Tranexamic acid
Brand Names
Cyklokapron 100 mg/ml
Tranexamic Acid Tablets
Lysteda
Skinmd Laboratories Pure Whitenol Serum
M-tranexamic Acid
SKINMD LABORATORIES ReviTox blue
Tranexamic acid
Pure Whitenol Serum
Tranexamic Acid
Cyklokapron
Tranexamic Acid Injection
Cyklokapron 500 mg
Tranexamic Acid Injection BP
Liquid
Skinmd Laboratories Pure Whitenol Intensive
Mar-tranexamic Acid
Tranexamic Acid Injection, USP
Gd-tranexamic Acid
Erfa-tranexamic
Tranexamic Acid In Sodium Chloride
Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema,[L31883] cyclic heavy menstrual bleeding in premenopausal females,[L31858] and other instances of significant bleeding in the context of hyperfibrinolysis.[L31883] Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.[L31853]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682