CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	vet_approved approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-(α-(2-Chlorophenyl)benzhydryl)imidazole 1-(o-Chloro-α,α-diphenylbenzyl)imidazole 1-(o-Chlorotrityl)imidazole Clotrimazolum 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazole Clotrimazol
Brand Names	Kleer-Plex Fungistat Fungus Cure Leader Athletes Foot Clotrimazole Forticept Antifungal Cooling Clotrimazole and Betamethasone Dipropionate Antifungal Foot Foot Care Clotrimazole Protective Nail and skin Terrasil Jock Itch Treatment Maximum Strength TM-Clotrimazole Canesoral Combi Canesten 3 Vaginal Tablet Combi-pak Canesten Combi-pak 1 Day Therapy Athletes Foot CVS Pharmacy ITCH RELIEF ANTIFUNGAL Clotrimazole Vaginal 6 Canesten 1 Day Internal Cream Terrasil Anti-fungal Treatment Jock Itch Clotrimazole Antifungal Our Family Athletes Foot Ringworm PRO-EX Anti Fungal Footlogix Kleer-Plex Fungistat Athlete Foot Cure Clotrimaderm Topical TopCare Antifungal Canesten 1% Topical Cream Live Better Antifungal 1MED Clotrimazole 1% Antifungal Cream Scheinpharm Clotrimazole 1% meijer Athletes Foot Clotrimazole Athletes Foot Mycozyl AC Fungicure Pumpspray Jock Itch Cream with Clotrimazole Dynarex Antifungal Myclo-gyne Inserts Oheal Manuka Honey Eczema Cream Protective and Moisturizing Skin Quality Choice Athletes Foot Family Care Antifungal Clotrimazole Extra Strength External Antifungal Cream Fungicure Manicure Pedicure Lakesia Canesten Vaginal Inserts 100mg Canesten Combi 3 Day Canesten 1 Vaginal Tablet Combi-pak Clotrimazole External Antifungal Cream SIMPLY VITAL Antifungal Cream Topcare Athletes Foot Neo-zol Cream 1% Canesten 3 Day Internal Cream Quality Choice Clotrimazole Smart Sense Athletes Foot Antifungal sunmark Clotrimazole 3 Fortinia OF Leader Clotrimazole Anti-Fungal Clotrimazol Smooth Gator Fungus Eliminator UpandUp Clotrimazole Fungicure Intensive Fungicure Manicure Pedicure Anti Fungal Gyne-Lotrimin 7 Blossom Pharmaceuticals Antifungal CAREALL Clotrimazole Atopalm Clotrimazole Antifungal Myclo Crm 50mg TopCare Clotrimazole 3 Antifungal Lucky SuperSoft Athletes Foot Canesten Crm 1% Vag Betamethasone Clotrimazole Clotrimazole Antifungal Terrasil Anti-Fungal Treatment Micotrin AC TheraPlus Plus Clotrimazole 1% Topical Antifungal Cream Up and Up Jock Itch Relief Kerasal foot and toe Canesten 6 Day Internal Cream Clotrimaderm External Cream Gyne-Lotrimin 3 Terrasil Tinea Treatment Maximum Strength FungaZoil Advanced CVSHealth Antifungal Dermatin Antifungal Jock Itch Best Choice Clotrimazole Shopko Athletes Foot Clotrimazole Topical Rugby Clotrimazole Antifungal Cream Alevazol Terrasil Anti-Fungal Treatment MAX Athlete s Foot Afac Femmesil Occulus Skin Hydrating Topical Foam CLO-1 Athlete Foot Cream with Clotrimazole Family Wellness Clotrimazole 1 Anti Fungal Cream ShopRite antifungal Family Wellness Antifungal Clotrimazole Jock Itch First Aid Research Antifungal .5oz Kroger Jock Itch Lotrisone Ciclomazole Myclo-derm Solution 1% Clotrimaderm-fluconazole Combi-pack Canesten Liq 1% JiDeSheng Astonea Clotrimazole 1% Athletes Foot Canesten V WinCo Antifungal Canesten 1% Topical Solution Terrasil Athletes Foot AntiFungal Treatment Max Canesten Crm 1% Top Canesten External Cream Oheal Ringworm Cream Meijer Clotrimazole Antifungal Sunmark Clotrimazole Family Care Clotrimazole Anti-Fungal Cream 1% Walgreens Clotrimazole Fastrin Anti - Fungal Skin Care Canesten 100mg Vaginal Inserts Terrasil Foot and Nail Anti-Fungal Exchange Select Atheletes foot Footlogix Intensive Care Diabetic Formula Soothing Antifungal Cream Clotrimazole Topical Solution USP, 1% Clotrimazole Akin Anti-fungal Clotrimazole Vaginal 3 Terrasil Tinea Treatment MAX Gehwol Fusskraft Nail and Skin Protection Good Sense Athletes Foot antifungal Terrasil Ringworm Treatment MAX Terbinafine HCl Chlortimazole and Tolnaftate Anti-Fungal Cream Myclo-gyne Cream 1% Pedesil Mycelex Goodsense Athletes Foot Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream CAREONE Clotrimazole Signature Care Antifungal MakeSense Up and Up Athletes Foot Jock-eze Shield and Protect Anti-Fungal Canesten Combi 1 Day Internal + External Creams Athletes Foot Antifungal Antifungal Au Kah Chuen Antifungal Clotrimazole External Cream Forticept Antifungal Foot Gel Myclo Crm 10mg Canesten Comfortab 3 Budpak Antifungal Clotrimazole CVS Clotrimazole Maximum Strength Terrasil Foot and Nail Anti-Fungal Maximum Strength ClotrimazOil Antifungal Canesten Extra Strength External Antifungal Cream WinCo Foods Antifungal Terrasil Rapid-Clear Anti-Fungal Signature Care Athletes Foot PMS-clotrimazole-betamethasone Signature Care Jock Itch Botanimedix TineaRX Antifungal Drying Emulsion Dr Sheffield Athletes Foot Myclo Solution Taro-clotrimazole/betamethasone Dipropionate Gehwol Nail Protection Pen Myclo-derm Cream 1% HEB Antifungal Terrasil Jock-Itch Treatment MAX CVS Pharmacy Clotrimazole 3 Gerlasan Hand Family Care Clotrimazole Antifungal Clotrimaderm Topical Solution 1% USP Fortinia Walgreens Jock Itch Kroger ATHLETES FOOT Antifungal Cream Walgreens Clotrimazole Antifungal Clotrimazole 1% Athletes Foot Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Clotrimazole Cream 1% Silka Ringworm Rexall Athletes Foot Good Neighbor Pharmacy Clotrimazole 3 Rite Aid antifungal ringworm Western Family Athletes Foot Clotrimazole Topical Solution 1% Canesten Soft Capsule 1 Zapotol Clotrimazole Clotrimazole 1% Clotrimaderm Vaginal 3 Publix athletic foot Canesten Combi 1 Day Equaline Antifungal Cream Hua Tuo Xian Gao Antifungal Canesten Comfortab 1 Extra Strength Clotrimazole Extra Fort -fluconazole Combi Lotriderm Clotrimaderm Vaginal 6 Jock Itch Antifungal Good Neighbor Pharmacy Clotrimazole meijer Clotrimazole 3 Myclo Tab 100mg Votriza-AL Fungicure Liquid Gel Fungistat Max Pedesil Maximum Strength Canesten Combi 1 Day Comfortab + Extra Strength External Cream Anti-Fungal Canesten 2% Vaginal Cream Rexall Jock Itch DermacinRx Therazole Pak SoundBody Clotrimazole Antifungal Skin Repair Lotrimin PerfectHeal Antifungal Thera plus Antifungal Clotrimazole Equaline Clotrimazole Antifungal Healthy Accents Antifungal Hua Tuo Xian Gao S-Cream CLOTRIMAZOLE Cream 1% Terrasil JockItch Treatment Maximum Strength Clotrimazole-fluconazole Combi Lotrimin Antifungal Walgreens Clotrimazole 3 Meijer Athletes Foot Cream AF Canesten 200 Mg Vaginal Inserts First Aid Research Antifungal Cream 1oz Anti Fungal Desenex Forticept Antifungal Foot Cream Rugby Antifungal Clotrimazole Cura Hongo Antifungal Fungicure Manicure Pedicure Liquid Gel Major Clotrimazole CVS Antifungal Ringworm Neo-zol Vaginal Cream 1% Clotrimazole/Betameth Canesoral Combi 1 Day Aptrimazole 1.0% Antifungal Cream Canesten External Antifungal Cream TerrasilMed ANTIFUNGAL Clotrimazol Dual Equate Jock Itch Neo-zol Vaginal Cream 2% Aspiera Anti-Fungal Olp Clotrimazole Gehwol med Foot Terrasil Antifungal Cream Maximum Strength
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682