CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-(o-Chloro-α,α-diphenylbenzyl)imidazole Clotrimazolum 1-(o-Chlorotrityl)imidazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazole Clotrimazol
Brand Names	Canesten Combi 1 Day Footlogix PMS-clotrimazole-betamethasone TM-Clotrimazole Canesten Crm 1% Vag Terbinafine HCl Chlortimazole and Tolnaftate Canesten External Cream Clotrimazole Topical Solution USP, 1% Clotrimaderm Topical CVS Antifungal Ringworm Dr Sheffield Athletes Foot Taro-clotrimazole/betamethasone Dipropionate meijer Clotrimazole 3 Antifungal Foot Family Wellness Antifungal Canesten Comfortab 1 Terrasil Ringworm Treatment MAX FungaZoil Advanced meijer Athletes Foot Smart Sense Athletes Foot Antifungal Meijer Clotrimazole Antifungal Terrasil Foot and Nail Anti-Fungal First Aid Research Antifungal Cream 1oz Footlogix Intensive Care Diabetic Formula JiDeSheng Protective Nail and skin Clotrimazole External Cream Au Kah Chuen Antifungal Clotrimazole 1% Athletes Foot Clotrimazole External Antifungal Cream Botanimedix TineaRX Antifungal Drying Emulsion Forticept Antifungal Foot Gel Fungicure Manicure Pedicure Liquid Gel Publix athletic foot Lotrisone MakeSense ClotrimazOil Antifungal Rexall Athletes Foot Good Neighbor Pharmacy Clotrimazole 3 Myclo Crm 50mg Canesoral Combi Forticept Antifungal Foot Cream Clotrimazole 1% Fungicure Manicure Pedicure Clotrimaderm Vaginal 3 Best Choice Clotrimazole Clotrimazole TerrasilMed ANTIFUNGAL Myclo-gyne Inserts Pedesil Athletes Foot Antifungal Antifungal Clotrimazole Vaginal 6 Forticept Antifungal Cooling Walgreens Clotrimazole WinCo Foods Antifungal Smooth Gator Fungus Eliminator TheraPlus Plus Gehwol Fusskraft Nail and Skin Protection SoundBody Clotrimazole Antifungal Neo-zol Vaginal Cream 1% Canesten 6 Day Internal Cream Terrasil Rapid-Clear Anti-Fungal Healthy Accents Antifungal Canesten 1 Vaginal Tablet Combi-pak Betamethasone Clotrimazole Lotriderm Kleer-Plex Fungistat Fungus Cure Canesten Vaginal Inserts 100mg Dermatin Antifungal Goodsense Athletes Foot Terrasil Athletes Foot AntiFungal Treatment Max Myclo Crm 10mg Canesten 1% Topical Solution Shield and Protect Anti-Fungal Clotrimazole Extra Strength External Antifungal Cream Athlete Foot Cream with Clotrimazole SIMPLY VITAL Antifungal Cream Equaline Antifungal Cream Ringworm Walgreens Jock Itch PRO-EX Anti Fungal Live Better Antifungal Myclo-derm Cream 1% Leader Clotrimazole Anti-Fungal Canesten Soft Capsule 1 Dynarex Antifungal Clotrimazole Jock Itch Exchange Select Atheletes foot Canesten 200 Mg Vaginal Inserts Kleer-Plex Fungistat Athlete Foot Cure S-Cream CLOTRIMAZOLE Cream 1% Shopko Athletes Foot PerfectHeal Antifungal Myclo-gyne Cream 1% Akin Anti-fungal Antifungal Canesten 3 Vaginal Tablet Combi-pak Jock Itch Antifungal Mycelex Astonea Clotrimazole 1% Athletes Foot Fastrin Anti - Fungal Skin Care Western Family Athletes Foot Jock Itch sunmark Clotrimazole 3 Jock-eze Gyne-Lotrimin 3 Myclo Tab 100mg Femmesil Terrasil Foot and Nail Anti-Fungal Maximum Strength Rugby Antifungal Clotrimazole Fungicure Pumpspray Canesten Combi 1 Day Internal + External Creams Canesten V Cura Hongo Antifungal Anti-Fungal Cream Family Wellness Clotrimazole 1 Anti Fungal Cream Kroger Jock Itch Myclo-derm Solution 1% Canesten Combi 3 Day Family Care Antifungal Terrasil Anti-Fungal Treatment MAX Foot Care Clotrimazole Canesten 1 Day Internal Cream Athlete s Foot Afac Kroger ATHLETES FOOT Clotrimazole/Betameth Fortinia Oheal Ringworm Cream Budpak Antifungal Clotrimazole Terrasil JockItch Treatment Maximum Strength Gyne-Lotrimin 7 Fungicure Intensive Canesten Liq 1% Mycozyl AC Our Family Athletes Foot Canesten Combi 1 Day Comfortab + Extra Strength External Cream Occulus Skin Hydrating Topical Foam CLO-1 Up and Up Athletes Foot CAREONE Clotrimazole Olp Clotrimazole Scheinpharm Clotrimazole 1% Rugby Clotrimazole Antifungal Cream Anti-Fungal Clotrimaderm Topical Solution 1% USP Rite Aid antifungal ringworm Thera plus Antifungal Clotrimazole Antifungal Cream 1MED Clotrimazole 1% Antifungal Cream Clotrimaderm External Cream Rexall Jock Itch Topcare Athletes Foot Canesten External Antifungal Cream Neo-zol Cream 1% Clotrimazole Cream 1% Canesten Combi-pak 1 Day Therapy Clotrimazole Topical Solution 1% Clotrimazole-fluconazole Combi WinCo Antifungal Zapotol Clotrimazole ShopRite antifungal Fungicure Manicure Pedicure Anti Fungal Terrasil Jock-Itch Treatment MAX Canesten Crm 1% Top Canesten Extra Strength External Antifungal Cream Jock Itch Clotrimazole Antifungal Neo-zol Vaginal Cream 2% Aptrimazole 1.0% Antifungal Cream Walgreens Clotrimazole 3 Terrasil Antifungal Cream Maximum Strength Quality Choice Clotrimazole Anti Fungal Clotrimazole Athletes Foot Alevazol Clotrimazole and Betamethasone Dipropionate Lakesia TopCare Clotrimazole 3 Clotrimazol Fortinia OF Skin Repair Good Sense Athletes Foot antifungal Kerasal foot and toe Soothing Antifungal Cream Walgreens Clotrimazole Antifungal Hua Tuo Xian Gao Antifungal Hua Tuo Xian Gao Lotrimin Antifungal Athletes Foot Micotrin AC Canesten 2% Vaginal Cream Lotrimin Canesten 1% Topical Cream Myclo Solution Terrasil Tinea Treatment Maximum Strength Clotrimaderm-fluconazole Combi-pack Quality Choice Athletes Foot CVS Clotrimazole Maximum Strength Atopalm Clotrimazole Antifungal Signature Care Jock Itch Votriza-AL Fungistat Max Leader Athletes Foot Clotrimazole Terrasil Anti-fungal Treatment Canesten 3 Day Internal Cream Desenex First Aid Research Antifungal .5oz Equate Jock Itch Gerlasan Hand Signature Care Antifungal Canesten Comfortab 3 Aspiera Anti-Fungal Fungicure Liquid Gel Clotrimazole 1% Topical Antifungal Cream Family Care Clotrimazole Antifungal Family Care Clotrimazole Anti-Fungal Cream 1% Good Neighbor Pharmacy Clotrimazole Ciclomazole Protective and Moisturizing Skin Equaline Clotrimazole Antifungal Gehwol Nail Protection Pen CVS Pharmacy Clotrimazole 3 HEB Antifungal Gehwol med Foot TopCare Antifungal Pedesil Maximum Strength Clotrimazole Vaginal 3 UpandUp Clotrimazole Up and Up Jock Itch Relief Canesoral Combi 1 Day Oheal Manuka Honey Eczema Cream Terrasil Tinea Treatment MAX Lucky SuperSoft Athletes Foot Canesten 100mg Vaginal Inserts Extra Strength Clotrimazole Extra Fort -fluconazole Combi Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Clotrimaderm Vaginal 6 Clotrimazole Antifungal DermacinRx Therazole Pak CVS Pharmacy ITCH RELIEF ANTIFUNGAL Signature Care Athletes Foot Silka Ringworm Sunmark Clotrimazole Terrasil Anti-Fungal Treatment Terrasil Jock Itch Treatment Maximum Strength Blossom Pharmaceuticals Antifungal Major Clotrimazole Jock Itch Cream with Clotrimazole CAREALL Clotrimazole CVSHealth Antifungal Clotrimazol Dual Meijer Athletes Foot Cream AF Clotrimazole Topical
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682