CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-(o-Chloro-α,α-diphenylbenzyl)imidazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazole Clotrimazolum Clotrimazol 1-(α-(2-Chlorophenyl)benzhydryl)imidazole 1-(o-Chlorotrityl)imidazole
Brand Names	PRO-EX Anti Fungal Terrasil Anti-Fungal Treatment MAX Fungicure Intensive meijer Athletes Foot TheraPlus Plus Myclo Crm 10mg Meijer Clotrimazole Antifungal Athletes Foot Antifungal Antifungal Atopalm Clotrimazole Antifungal Betamethasone Clotrimazole Smooth Gator Fungus Eliminator Walgreens Jock Itch Gyne-Lotrimin 3 Gyne-Lotrimin 7 Good Neighbor Pharmacy Clotrimazole Signature Care Athletes Foot Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Gehwol Fusskraft Nail and Skin Protection Good Neighbor Pharmacy Clotrimazole 3 Lotriderm Fungicure Manicure Pedicure Clotrimaderm Vaginal 3 Publix athletic foot Protective and Moisturizing Skin Clotrimazol Canesten Comfortab 1 Clotrimazole 1% Topical Antifungal Cream Myclo-gyne Inserts Rugby Antifungal Clotrimazole Canesten Comfortab 3 Athlete Foot Cream with Clotrimazole Dr Sheffield Athletes Foot Forticept Antifungal Foot Cream Forticept Antifungal Cooling Micotrin AC SoundBody Clotrimazole Antifungal Rexall Athletes Foot Oheal Manuka Honey Eczema Cream Leader Athletes Foot Clotrimazole Gerlasan Hand Hua Tuo Xian Gao Antifungal PMS-clotrimazole-betamethasone Canesoral Combi 1 Day Anti-Fungal Cream Aptrimazole 1.0% Antifungal Cream TopCare Clotrimazole 3 Quality Choice Athletes Foot Equaline Clotrimazole Antifungal Smart Sense Athletes Foot Antifungal Gehwol med Foot Clotrimaderm Topical Clotrimazole 1% Athletes Foot Shopko Athletes Foot Extra Strength Clotrimazole Extra Fort -fluconazole Combi Sunmark Clotrimazole CAREONE Clotrimazole Dynarex Antifungal Up and Up Athletes Foot Lotrimin Antifungal SIMPLY VITAL Antifungal Cream Canesten Combi 1 Day Comfortab + Extra Strength External Cream CAREALL Clotrimazole Terrasil Ringworm Treatment MAX Western Family Athletes Foot Canesten Combi 1 Day sunmark Clotrimazole 3 Fungicure Manicure Pedicure Anti Fungal Canesten 100mg Vaginal Inserts Canesten 1 Day Internal Cream TerrasilMed ANTIFUNGAL Clotrimazole External Antifungal Cream Footlogix Intensive Care Diabetic Formula Family Care Clotrimazole Antifungal Desenex Soothing Antifungal Cream CVS Clotrimazole Maximum Strength Footlogix Clotrimazole Topical DermacinRx Therazole Pak Kroger Jock Itch Canesoral Combi 1MED Clotrimazole 1% Antifungal Cream Clotrimazole Terrasil Jock Itch Treatment Maximum Strength Canesten 3 Day Internal Cream Gehwol Nail Protection Pen JiDeSheng Kerasal foot and toe PerfectHeal Antifungal Equaline Antifungal Cream S-Cream CLOTRIMAZOLE Cream 1% Signature Care Antifungal TM-Clotrimazole Skin Repair Best Choice Clotrimazole Clotrimazole Cream 1% Family Wellness Antifungal MakeSense Taro-clotrimazole/betamethasone Dipropionate Fortinia OF Terrasil Rapid-Clear Anti-Fungal Myclo-derm Solution 1% Clotrimazole Topical Solution USP, 1% Exchange Select Atheletes foot Clotrimazole Antifungal Major Clotrimazole Canesten Crm 1% Vag FungaZoil Advanced Terrasil JockItch Treatment Maximum Strength Canesten Crm 1% Top Femmesil Clotrimaderm External Cream Neo-zol Vaginal Cream 2% Clotrimaderm Vaginal 6 Canesten External Cream Terrasil Anti-fungal Treatment Clotrimazole 1% Antifungal Cream Jock Itch Cream with Clotrimazole First Aid Research Antifungal .5oz Kleer-Plex Fungistat Athlete Foot Cure Clotrimazole Vaginal 3 Myclo Crm 50mg Mycozyl AC Ringworm Clotrimazole Athletes Foot Walgreens Clotrimazole 3 Blossom Pharmaceuticals Antifungal Fastrin Anti - Fungal Skin Care WinCo Foods Antifungal Canesten External Antifungal Cream Canesten 200 Mg Vaginal Inserts Jock Itch Antifungal Meijer Athletes Foot Cream AF Thera plus Antifungal Clotrimazole Terrasil Foot and Nail Anti-Fungal Maximum Strength Canesten Extra Strength External Antifungal Cream Terrasil Foot and Nail Anti-Fungal Clotrimazole and Betamethasone Dipropionate Pedesil Hua Tuo Xian Gao Lotrimin Clotrimazole Extra Strength External Antifungal Cream Votriza-AL Jock Itch Clotrimazole Antifungal Kroger ATHLETES FOOT Walgreens Clotrimazole Antifungal Clotrimazol Dual Clotrimazole Vaginal 6 Myclo-gyne Cream 1% Budpak Antifungal Clotrimazole Canesten 1% Topical Cream Clotrimazole External Cream Jock Itch Rite Aid antifungal ringworm Up and Up Jock Itch Relief Walgreens Clotrimazole Lakesia Antifungal Quality Choice Clotrimazole Lotrisone Ciclomazole Zapotol Clotrimazole Canesten 6 Day Internal Cream Anti-Fungal Topcare Athletes Foot Lucky SuperSoft Athletes Foot Our Family Athletes Foot Myclo-derm Cream 1% Akin Anti-fungal Terrasil Tinea Treatment Maximum Strength meijer Clotrimazole 3 Canesten 1% Topical Solution Family Wellness Clotrimazole 1 Anti Fungal Cream Scheinpharm Clotrimazole 1% Family Care Clotrimazole Anti-Fungal Cream 1% Fungistat Max CVS Pharmacy ITCH RELIEF ANTIFUNGAL Canesten V Clotrimaderm Topical Solution 1% USP First Aid Research Antifungal Cream 1oz Leader Clotrimazole Anti-Fungal ClotrimazOil Antifungal Goodsense Athletes Foot CVS Pharmacy Clotrimazole 3 Good Sense Athletes Foot antifungal Oheal Ringworm Cream Clotrimazole-fluconazole Combi Live Better Antifungal HEB Antifungal Myclo Tab 100mg WinCo Antifungal UpandUp Clotrimazole Forticept Antifungal Foot Gel Clotrimaderm-fluconazole Combi-pack Botanimedix TineaRX Antifungal Drying Emulsion Canesten Soft Capsule 1 Myclo Solution Protective Nail and skin Silka Ringworm Au Kah Chuen Antifungal Clotrimazole/Betameth ShopRite antifungal Dermatin Antifungal Terrasil Antifungal Cream Maximum Strength TopCare Antifungal Neo-zol Vaginal Cream 1% Terrasil Jock-Itch Treatment MAX Astonea Clotrimazole 1% Athletes Foot Canesten Combi-pak 1 Day Therapy Healthy Accents Antifungal Equate Jock Itch Terrasil Anti-Fungal Treatment Terrasil Athletes Foot AntiFungal Treatment Max Canesten Vaginal Inserts 100mg Signature Care Jock Itch Foot Care Clotrimazole Canesten 3 Vaginal Tablet Combi-pak Fungicure Pumpspray Neo-zol Cream 1% Rugby Clotrimazole Antifungal Cream CVSHealth Antifungal Terrasil Tinea Treatment MAX Alevazol Canesten 2% Vaginal Cream Occulus Skin Hydrating Topical Foam CLO-1 Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Jock-eze Kleer-Plex Fungistat Fungus Cure Mycelex Rexall Jock Itch Pedesil Maximum Strength Canesten Liq 1% Olp Clotrimazole Cura Hongo Antifungal Shield and Protect Anti-Fungal CVS Antifungal Ringworm Canesten Combi 1 Day Internal + External Creams Antifungal Foot Family Care Antifungal Athlete s Foot Afac Canesten Combi 3 Day Fungicure Liquid Gel Canesten 1 Vaginal Tablet Combi-pak Clotrimazole Jock Itch Terbinafine HCl Chlortimazole and Tolnaftate Aspiera Anti-Fungal Clotrimazole Topical Solution 1% Fungicure Manicure Pedicure Liquid Gel Athletes Foot Anti Fungal Fortinia
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682