This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms
1-(α-(2-Chlorophenyl)benzhydryl)imidazole
Clotrimazole
Clotrimazolum
1-(o-Chloro-α,α-diphenylbenzyl)imidazole
Clotrimazol
1-(o-Chlorotrityl)imidazole
1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
Brand Names
Lakesia
Canesten Combi 3 Day
CAREALL Clotrimazole
Canesten 200 Mg Vaginal Inserts
Signature Care Antifungal
Clotrimazol Dual
Clotrimazole External Antifungal Cream
SoundBody Clotrimazole Antifungal
First Aid Research Antifungal Cream 1oz
Walgreens Clotrimazole
TopCare Antifungal
Leader Clotrimazole Anti-Fungal
PMS-clotrimazole-betamethasone
Kroger ATHLETES FOOT
TopCare Clotrimazole 3
Up and Up Jock Itch Relief
Antifungal Cream
Canesten 2% Vaginal Cream
FungaZoil Advanced
Antifungal Foot
Dynarex Antifungal
Canesten 1 Vaginal Tablet Combi-pak
Clotrimazole Topical Solution 1%
Terrasil Anti-fungal Treatment
Terrasil Jock Itch Treatment Maximum Strength
Dr Sheffield Athletes Foot
Jock Itch Cream with Clotrimazole
Lotrimin
Lucky SuperSoft Athletes Foot
Smooth Gator Fungus Eliminator
Jock Itch Clotrimazole Antifungal
Major Clotrimazole
Betamethasone Clotrimazole
Canesten 1% Topical Solution
Clotrimaderm Vaginal 6
HEB Antifungal
Athletes Foot Antifungal Antifungal
Terrasil Foot and Nail Anti-Fungal
Soothing Antifungal Cream
Good Neighbor Pharmacy Clotrimazole 3
Rugby Clotrimazole Antifungal Cream
WinCo Foods Antifungal
Clotrimaderm Topical Solution 1% USP
TM-Clotrimazole
PerfectHeal Antifungal
Up and Up Athletes Foot
Skin Repair
Cura Hongo Antifungal
Extra Strength Clotrimazole Extra Fort -fluconazole Combi
Clotrimazole Extra Strength External Antifungal Cream
Canesten Extra Strength External Antifungal Cream
Fungistat Max
Clotrimazole External Cream
DermacinRx Therazole Pak
Canesten External Cream
Clotrimazole Athletes Foot
Canesten Comfortab 1
MakeSense
Western Family Athletes Foot
Clotrimazole 1% Topical Antifungal Cream
Terrasil Antifungal Cream Maximum Strength
Myclo Tab 100mg
Canesten External Antifungal Cream
Family Care Antifungal
Canesten Liq 1%
Clotrimaderm Vaginal 3
Signature Care Jock Itch
Rexall Jock Itch
Clotrimazole 1%
Neo-zol Vaginal Cream 1%
Canesten 1% Topical Cream
Canesten Combi 1 Day Comfortab + Extra Strength External Cream
Shield and Protect Anti-Fungal
Leader Athletes Foot Clotrimazole
Terbinafine HCl Chlortimazole and Tolnaftate
Ringworm
Protective and Moisturizing Skin
Gehwol Fusskraft Nail and Skin Protection
TheraPlus Plus
JiDeSheng
Canesten Crm 1% Vag
Athletes Foot
Lotriderm
Forticept Antifungal Cooling
meijer Athletes Foot
Canesten Combi 1 Day
Pedesil
Terrasil Athletes Foot AntiFungal Treatment Max
Fungicure Liquid Gel
Votriza-AL
Canesten Crm 1% Top
Fungicure Manicure Pedicure
CVS Pharmacy ITCH RELIEF ANTIFUNGAL
Au Kah Chuen Antifungal
Athlete Foot Cream with Clotrimazole
Equaline Clotrimazole Antifungal
Blossom Pharmaceuticals Antifungal
Meijer Clotrimazole Antifungal
First Aid Research Antifungal .5oz
Lotrimin Antifungal
Myclo-derm Cream 1%
Protective Nail and skin
Clotrimazole Antifungal
Canesten 6 Day Internal Cream
Clotrimazole Jock Itch
Quality Choice Clotrimazole
Clotrimaderm External Cream
S-Cream CLOTRIMAZOLE Cream 1%
ShopRite antifungal
Terrasil Anti-Fungal Treatment
Fortinia OF
Canesten 100mg Vaginal Inserts
Terrasil Tinea Treatment Maximum Strength
Clotrimazole Vaginal 6
Forticept Antifungal Foot Cream
Clotrimazole-fluconazole Combi
Hua Tuo Xian Gao Antifungal
Myclo Crm 50mg
CVSHealth Antifungal
Mycelex
Scheinpharm Clotrimazole 1%
Clotrimazole Topical Solution USP, 1%
Gyne-Lotrimin 7
Gerlasan Hand
Myclo-gyne Inserts
Jock Itch Antifungal
TerrasilMed ANTIFUNGAL
CVS Antifungal Ringworm
Zapotol Clotrimazole
PRO-EX Anti Fungal
Rexall Athletes Foot
Healthy Accents Antifungal
Signature Care Athletes Foot
Walgreens Clotrimazole Antifungal
Equaline Antifungal Cream
Terrasil Foot and Nail Anti-Fungal Maximum Strength
Alevazol
Fastrin Anti - Fungal Skin Care
1MED Clotrimazole 1% Antifungal Cream
Canesten Soft Capsule 1
Antifungal
Goodsense Athletes Foot
Family Care Clotrimazole Antifungal
Clotrimazol
Gyne-Lotrimin 3
Clotrimaderm Topical
Myclo-derm Solution 1%
Our Family Athletes Foot
SIMPLY VITAL Antifungal Cream
Canesten Vaginal Inserts 100mg
Ciclomazole
Sunmark Clotrimazole
Rite Aid antifungal ringworm
Budpak Antifungal Clotrimazole
Clotrimazole Topical
Footlogix Intensive Care Diabetic Formula
Jock Itch
Kroger Jock Itch
Gehwol med Foot
Anti-Fungal Cream
CVS Clotrimazole Maximum Strength
Family Wellness Antifungal
Canesoral Combi
Good Sense Athletes Foot antifungal
Equate Jock Itch
Shopko Athletes Foot
Canesten 3 Day Internal Cream
Meijer Athletes Foot Cream AF
Olp Clotrimazole
Myclo Crm 10mg
Astonea Clotrimazole 1% Athletes Foot
Dermatin Antifungal
Topcare Athletes Foot
Clotrimazole 1% Athletes Foot
Kleer-Plex Fungistat Fungus Cure
Clotrimazole and Betamethasone Dipropionate
Clotrimazole
Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream
WinCo Antifungal
Occulus Skin Hydrating Topical Foam CLO-1
Desenex
Fungicure Manicure Pedicure Liquid Gel
Family Care Clotrimazole Anti-Fungal Cream 1%
Silka Ringworm
Botanimedix TineaRX Antifungal Drying Emulsion
Canesten 1 Day Internal Cream
Foot Care Clotrimazole
UpandUp Clotrimazole
Mycozyl AC
Fungicure Manicure Pedicure Anti Fungal
Walgreens Clotrimazole 3
Family Wellness Clotrimazole 1 Anti Fungal Cream
meijer Clotrimazole 3
Myclo-gyne Cream 1%
Athlete s Foot Afac
Kleer-Plex Fungistat Athlete Foot Cure
Live Better Antifungal
Exchange Select Atheletes foot
Neo-zol Cream 1%
Kerasal foot and toe
Taro-clotrimazole/betamethasone Dipropionate
CAREONE Clotrimazole
Indication
**Topical preparations** Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. **Oral preparations** The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories
Anti-Infective Agents
Anti-Infective Agents, Local
Antifungal Agents
Antifungal Agents (Vaginal)
Antifungals for Dermatological Use
Antifungals for Topical Use
Antiinfectives and Antiseptics for Local Oral Treatment
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
