CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	vet_approved approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	Clotrimazolum 1-(o-Chloro-α,α-diphenylbenzyl)imidazole Clotrimazol 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazole 1-(o-Chlorotrityl)imidazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole
Brand Names	Antifungal Cream Akin Anti-fungal Canesten 1% Topical Cream Clotrimazole 1% Clotrimazole Cream 1% Thera plus Antifungal Clotrimazole Terrasil JockItch Treatment Maximum Strength Our Family Athletes Foot Clotrimaderm-fluconazole Combi-pack Femmesil Rexall Athletes Foot First Aid Research Antifungal .5oz Canesten Comfortab 3 Major Clotrimazole Myclo-derm Solution 1% Equaline Clotrimazole Antifungal Canesten Crm 1% Top Gehwol Fusskraft Nail and Skin Protection Canesoral Combi 1 Day CAREALL Clotrimazole Clotrimazole Topical Solution USP, 1% Leader Athletes Foot Clotrimazole Extra Strength Clotrimazole Extra Fort -fluconazole Combi Quality Choice Athletes Foot Clotrimazole/Betameth Fungicure Manicure Pedicure Forticept Antifungal Cooling Oheal Manuka Honey Eczema Cream Jock Itch Cream with Clotrimazole Smart Sense Athletes Foot Antifungal Terrasil Athletes Foot AntiFungal Treatment Max Walgreens Jock Itch Terrasil Anti-Fungal Treatment MAX Clotrimazol Dual WinCo Antifungal Terrasil Tinea Treatment Maximum Strength Athletes Foot Meijer Athletes Foot Cream AF Canesten Combi 1 Day Internal + External Creams Family Care Clotrimazole Antifungal Oheal Ringworm Cream ShopRite antifungal Canesten 1 Day Internal Cream Terrasil Anti-Fungal Treatment Dermatin Antifungal Rite Aid antifungal ringworm Kroger Jock Itch Fungicure Manicure Pedicure Anti Fungal Canesten 1 Vaginal Tablet Combi-pak PerfectHeal Antifungal Kleer-Plex Fungistat Fungus Cure Hua Tuo Xian Gao Clotrimazole-fluconazole Combi FungaZoil Advanced Fungicure Intensive SoundBody Clotrimazole Antifungal Pedesil Maximum Strength CVS Pharmacy ITCH RELIEF ANTIFUNGAL Fortinia OF Gehwol med Foot Athletes Foot Antifungal Antifungal Neo-zol Vaginal Cream 1% CAREONE Clotrimazole Healthy Accents Antifungal Leader Clotrimazole Anti-Fungal Myclo-derm Cream 1% Canesten 200 Mg Vaginal Inserts Family Care Antifungal Myclo-gyne Cream 1% TopCare Antifungal UpandUp Clotrimazole Terrasil Jock Itch Treatment Maximum Strength Antifungal Family Care Clotrimazole Anti-Fungal Cream 1% Rugby Clotrimazole Antifungal Cream Gyne-Lotrimin 7 Forticept Antifungal Foot Cream Alevazol Sunmark Clotrimazole TM-Clotrimazole Dr Sheffield Athletes Foot Fastrin Anti - Fungal Skin Care Canesten Extra Strength External Antifungal Cream Canesten 6 Day Internal Cream CVSHealth Antifungal Western Family Athletes Foot Clotrimazole Topical Clotrimaderm Topical Lotrimin Antifungal Atopalm Clotrimazole Antifungal meijer Clotrimazole 3 Clotrimazol Clotrimazole and Betamethasone Dipropionate Canesten V CVS Pharmacy Clotrimazole 3 Anti Fungal Gehwol Nail Protection Pen Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM sunmark Clotrimazole 3 Footlogix Intensive Care Diabetic Formula Up and Up Jock Itch Relief Footlogix Lotrimin Micotrin AC TopCare Clotrimazole 3 Votriza-AL PRO-EX Anti Fungal Canesten Combi 1 Day Comfortab + Extra Strength External Cream S-Cream CLOTRIMAZOLE Cream 1% Canesten External Antifungal Cream Exchange Select Atheletes foot PMS-clotrimazole-betamethasone Fortinia Clotrimazole Vaginal 3 Dynarex Antifungal Mycozyl AC Equaline Antifungal Cream Family Wellness Clotrimazole 1 Anti Fungal Cream Canesten 1% Topical Solution Terrasil Jock-Itch Treatment MAX Best Choice Clotrimazole Walgreens Clotrimazole Antifungal Myclo Tab 100mg Shield and Protect Anti-Fungal Terrasil Anti-fungal Treatment Meijer Clotrimazole Antifungal Pedesil HEB Antifungal Athlete s Foot Afac Lakesia MakeSense Terrasil Foot and Nail Anti-Fungal Maximum Strength Canesten Combi 3 Day Good Neighbor Pharmacy Clotrimazole 3 JiDeSheng Forticept Antifungal Foot Gel Desenex Walgreens Clotrimazole Myclo-gyne Inserts Hua Tuo Xian Gao Antifungal TheraPlus Plus Clotrimazole 1% Topical Antifungal Cream Myclo Crm 50mg Canesten 3 Vaginal Tablet Combi-pak Aspiera Anti-Fungal Scheinpharm Clotrimazole 1% Canesten Vaginal Inserts 100mg Canesten Crm 1% Vag Fungistat Max Myclo Crm 10mg Kerasal foot and toe Quality Choice Clotrimazole Ringworm Soothing Antifungal Cream DermacinRx Therazole Pak Canesten 3 Day Internal Cream Clotrimazole Antifungal Fungicure Pumpspray Family Wellness Antifungal Betamethasone Clotrimazole Kroger ATHLETES FOOT Publix athletic foot Silka Ringworm Mycelex Terrasil Antifungal Cream Maximum Strength Taro-clotrimazole/betamethasone Dipropionate Good Sense Athletes Foot antifungal CVS Antifungal Ringworm Cura Hongo Antifungal Jock Itch Signature Care Athletes Foot Rugby Antifungal Clotrimazole Budpak Antifungal Clotrimazole Protective Nail and skin Gyne-Lotrimin 3 Clotrimazole Extra Strength External Antifungal Cream Botanimedix TineaRX Antifungal Drying Emulsion Up and Up Athletes Foot Jock Itch Clotrimazole Antifungal Terrasil Foot and Nail Anti-Fungal 1MED Clotrimazole 1% Antifungal Cream Clotrimazole External Antifungal Cream Terbinafine HCl Chlortimazole and Tolnaftate Rexall Jock Itch Zapotol Clotrimazole Clotrimaderm Vaginal 3 Goodsense Athletes Foot Clotrimaderm Topical Solution 1% USP Good Neighbor Pharmacy Clotrimazole Signature Care Jock Itch Lucky SuperSoft Athletes Foot Clotrimazole Topical Solution 1% Foot Care Clotrimazole Kleer-Plex Fungistat Athlete Foot Cure Occulus Skin Hydrating Topical Foam CLO-1 CVS Clotrimazole Maximum Strength Astonea Clotrimazole 1% Athletes Foot Shopko Athletes Foot Topcare Athletes Foot Live Better Antifungal Myclo Solution meijer Athletes Foot Clotrimaderm Vaginal 6 Clotrimazole External Cream Protective and Moisturizing Skin Canesoral Combi Canesten Combi 1 Day Anti-Fungal Cream Neo-zol Cream 1% Clotrimazole 1% Athletes Foot Ciclomazole Aptrimazole 1.0% Antifungal Cream Terrasil Tinea Treatment MAX Canesten Combi-pak 1 Day Therapy Fungicure Liquid Gel Clotrimazole Jock Itch Anti-Fungal Canesten Comfortab 1 Canesten 2% Vaginal Cream Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Gerlasan Hand Canesten 100mg Vaginal Inserts Jock-eze Au Kah Chuen Antifungal SIMPLY VITAL Antifungal Cream Blossom Pharmaceuticals Antifungal Terrasil Rapid-Clear Anti-Fungal Lotrisone Smooth Gator Fungus Eliminator Clotrimazole Athletes Foot Equate Jock Itch Skin Repair Walgreens Clotrimazole 3 Signature Care Antifungal Lotriderm Terrasil Ringworm Treatment MAX Antifungal Foot Olp Clotrimazole ClotrimazOil Antifungal Clotrimaderm External Cream Clotrimazole Vaginal 6 Canesten Liq 1% First Aid Research Antifungal Cream 1oz Athlete Foot Cream with Clotrimazole Canesten External Cream Fungicure Manicure Pedicure Liquid Gel Jock Itch Antifungal Neo-zol Vaginal Cream 2% WinCo Foods Antifungal Clotrimazole Canesten Soft Capsule 1 TerrasilMed ANTIFUNGAL
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682