Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Synonyms
Gabapentin
Gabapentine
1-(Aminomethyl)cyclohexaneacetic acid
Gabapentinum
Gabapentino
Gabapentina
Brand Names
Pro-gabapentin
Priva-gabapentin
Gaba 300-EZS
Jamp-gabapentin Tablets
Pendo-gabapentin
Prilopentin
Gabacaine
GPL Pak
Ipg-gabapentin
Lidotin
Lipritin
Apo-gabapentin
Mar-gabapentin
Innoprax-5
Ran-gabapentin
Riva-gabapentin
Bio-gabapentin
Nu-gabapentin Capsules
Lipritin II
Therapentin-60
Dom-gabapentin
Gabapentin Capsules
Gapeam Budibac
Auro-gabapentin Tablets
Taro-gabapentin
Ag-gabapentin
Mylan-gabapentin
Bci Gabapentin
Gabapentin Tablets USP
Gd-gabapentin
PMS-gabapentin
Gralise Starter Pack
Ratio-gabapentin
Gabapentin
Dipentocaine Topical Cream Compounding Kit
Jamp Gabapentin Capsules
Gabapentin Capsules USP
Jamp-gabapentin
Ntp-gabapentin
Gabapentin Kit
Prilopentin -II
Apo-gabapentin Tablets
SmartRx Gaba Kit
Act Gabapentin
Gln-gabapentin
Van-gabapentin
PHL-gabapentin
ACTIVE-PAC with Gabapentin
Auro-gabapentin
Therapentin-90
Gabapal
Pentican
Fanatrex
Mar-gabapentin Tabs
Lido GB-300
Gabarone
Cyclo/Gaba 10/300 Pack
Topical Nerve Pain
Mint-gabapentin
Neurontin
Nra-gabapentin
Sig-gabapentin
SmartRx Gaba-V Kit
Teva-gabapentin
Gralise
Indication
In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.[L8717] In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.[L8732]
Categories
Acids, Acyclic
Acids, Carbocyclic
Amines
Amino Acids
Amino Acids, Peptides, and Proteins
Aminobutyrates
Analgesics
Anti-epileptic Agent
Anticonvulsants
Butyrates
Central Nervous System Agents
Central Nervous System Depressants
Cyclohexanecarboxylic Acids
Cyclohexanes
Cycloparaffins
Decreased Central Nervous System Disorganized Electrical Activity
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682