HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Hidrocortisona 17-Hydroxycorticosterone (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione Hydrocortisonum 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione 11beta-hydrocortisone 11β-hydrocortisone 4-pregnen-11β,17α,21-triol-3,20-dione Cortisol Reichstein's substance M Kendall's compound F Hydrocortisone
Brand Names	Quality Choice Itch Relief Hydrocortisone 1% in Absorbase Poison Oak and Ivy Face Values Hydrocortisone With Aloe sunmark Hydrocortisone Shopko Hydrocortisone Maximum Strength Cortizone 10 Hydratensive Soothing Anti Itch 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Cortate Ont 1% Xpect Hydrocortisone Ala Quin Cortisone FixMySkin Healing Balm Unflavored Preparation H Hydrocortisone Pharmaskincare Acnecare Cream CVS Pharmacy Anti-itch Dermoscribe Seborrheic Dermatitis Quadrydern WinCo Foods Hydrocortisone Cream Intensive Healing Meijer Anti Itch Barmicil Plus Sunmark Hydrocortisone Plus Sandoz Hydrocortisone Regular Strength Hydrocortisone Cream Hydrocortisone with Aloe Scarguard MD Physicians Formula Proctosedyl Ointment Up and Up Intensive Healing Maximum Strength Cortizone 10 Quick Shot 360 Continuous Up and Up Hydrocortisone Anti Itch Smart sense Hydrocortisone Kera HC AVON HeXashield Anti Itch Cream with Healing Aloe Hycort Retention Enema 100mg/60ml Intensive Healing Eczema Meijer Maximum Strength Anti-itch Cream with Aloe Proctozone-HC Fulton Street Market Anti itch Itch relief Cream FixMySkin HEALING LIP BALM unflavoured Equate Hydrocortisone Aquanil HC Meijer Maximum Strength Anti-itch Hydrocortisone Cream 1% Pharmaskincare Multi-Gly Skin Relief Cream Cortizone 10 Feminine Itch Relief Plenadren SAFEWAY Hydrocortisone Plus 12 Moisturizers Green Guard Maximum Strength Hydrocortisone Hydrocortisone D Medi-First Hydrocortisone Rexall Anti Itch Maximum Strength Relief Harris Teeter Maximum Strength Anti-Itch Hydrocortisone Cream 1% with Aloe Vera Instant Cooling Itch Relief Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Refuge HC Hydroxate Gel Cortenema CVS Health Hydrocortisone Anti Itch Nizoral Scalp Itch Relief meijer Hydrocortisone Equaline Anti Itch Xerese Natureplex Hydrocortisone Hydro Selsun Blue Scalp Itch Treatment Scarguard MD Vanoxide HC Rexall Hydrocortisone 1 ATOPALM Moisturizing Hydrocortisone Neomycin, Polymyxin B Sulfates and Hydrocortisone Pediadermics Eczema 2 Smart Sense Anti Itch Hydrocortisone Plus 12 Moisturizers Maximum Strength Thera plus Anti-itch with aloe Hydrocortisone Leader Hydrocortisone With Aloe Acetasol HC Hydrocortisone 2.5% / Ketoconazole 2% Hydro Ear Cortisporin Family Care Anti-Itch glo SKIN BEAUTY Remedy Gel DG Health Hydrocortisone Maximum Strength CVS Cortisone Care One Hydrocortisone Maximum Strength Corticol-Aloe Dermarest Dricort 0.5% Hydrocortisone Anti-itch TheraCare Maximum Strength 1% Hydrocortisone Cicatricure Ultra Moisturizing H-Releve Anti-Itch Itch Fixer Pramoxine-HC Harris Teeter Anti-Itch Intensive Healing Dermoscribe Ichybum Hydroxym Cipro HC Otic Suspension Shopko Hydrocortisone Blue-Emu Anti-Itch Cream Alacort Poison Oak Cortizone 10 Intensive Healing for Eczema Dr. Sheffield Hydrocortisone Anti itch Family Wellness Hydrocortisone Cortaine -B Aqueous Hydro Skin Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Maximum Strength Hydrocortisone Cream Mycozyl HC Live Better Hydrocortisone with Aloe WinCo Maximum Strength Hydrocortisone Neosporin Essentials Trial Pack Sarna Whipped Foam Hydrocortisone Plus 12 Moisturizers Theracort Quatriderm Creme Nf CeraVe Developed with Dermatologists Anti Itch Cortizone 10 Ultra Soothing Creme Pediaderm HC Aveeno Hydrocortisone Anti-itch Cream ProCure Hydrocortisone Plus Calendula Proctosedyl Sup Anti itch Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Eczema Skin Mushatts N9 Duane Reade hydrocortisone plus 12 moisturizers Hydrocortisone Cream Hydrocortisone 1 Plus 10 Alcortin First Aid Only Hydrocortisone 1% Anti-Itch Bencort Shopko Hydrocortisone With Aloe Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz Aloe Cort Duane Reade Exchange Select Hydrocortisone Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Anti-Itch Scalp Relief Maximum Strength Hydrocortisone Rectal Suspension (Retention) Itch and Bite Relief First Aid Kit Maximum Strength Hydrocortisone Plus Moisturizing Aloe Cortizone 10 for Psoriasis Members Mark Hydrocortisone Pharmaskincare Brightening Dermarelief Cream Triple Antibiotic HC 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Viniferamine Hydrocortisone Cream Proctosol-HC Freds Hydrocortisone Plus 12 Moisturizers Walgreens Hydrocortisone Plus 12 Moisturizers Meijer Maximum Strength Anti-itch Cream wiith Aloe Smart Sense Hydrocortisone Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Cortisone 10 Intensive Moisture Creme Welly Superhero Supplies Kit Neosporin Eczema Essentials Anti Itch Lucky SuperSoft MAXIMUM STRENGTH Alumier MD Intensive Recovery Cvs Hydrocortisone With Aloe Cortisone maximum strength Dermarest Eczema Medicated Cortizone 10 Post-Treatment Repair Cream Hydrocortisone and Acetic Acid HydroCortisone Intensive Healing Formula Healing Tree Calming Anti-itch Cortizone 10 Cooling Relief Sterex Lot Plus Cortisone 10 Overnight Creme Maximum-H TheraCare Hydrocortisone Cream Hydrocortisone Intensive Healing Formula Efmody 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Hytone Loesch HC-10 ANTI-ITCH THERAPY Anti-Itch with Aloe Maximum Strength Hydrocortisone TopCare Hydrocortisone Plus 12 Moisturizers Oti Rx Barriere HC 1% Antibiotic Ear (Neo/Polym/HC) Emo Cort Lotion 2.5% Western Family HydroCortisone Itch Relief Smart Sense Anti Itch Maximum Strength Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Maximum Strength Anti-Itch Meijer Anti-itch with Aloe Hydrocortisone Cream USP 0.5% Cortizone 10 Intensive Healing Feminine Itch Relief Hydrocortisone Crm 0.5% Welly Adventure First Aid Kit Cipro HC Hydrocortisone With Aloe Maximum Strength Cortisone 1% Hydrocortisone Sterex Crm Plus PS-2896 Hydrocortisone Cream 1%, 0.9g OLIVIA QUIDO FIRM and FADE II Cortizone 10 Cooling Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% Hydrocortisone Regular Strength ECOLAB Hydrocortisone Cream CareOne Anti Itch Aquaphor Itch Relief Hydrocortisone 1% Cortate Crm 1% TrueLipids 1% Hydrocortisone Barrier Cream CliniCalm Ana Cool Rapid Soothing Cooling Formula Rugby Hydroskin Makesense Maximum Strength Cooling Itch Relief Well at Walgreens Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Audiologist Anti-itch Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Formu Care Anti Itch maximum strength Calmurid HC Crm Atopalm Maximum Strength Anti-Itch Yes To Coconut Eczema Relief Alumier MD Post Procedure Kit with Hydrocortisone Hydrocortisone Cream 0.5% HydrocortisoneLotion Careone Hydrocortisone 1 Maximum Strength FixMySkin Healing Balm Fragrance-Free Rodan and Fields Soothe Procto-Pak CVS Maximum Strength Anti-Itch Cream Caring Mills Hydrocortisone Cortomycin Hydrocortisone Butyrate meijer Hydrocortisone Plus 12 Moisturizers Cho-A Care Lot 1% Sarna HC Auro-hydrocortisone Emo Cort Sol 2.5% USP Home PapKit Family Care Hydrocortisone Psoriasin Itch Control Careone Anti Itch Vioform + Hydrocortisone Piyanping antiitch 999 Itch Relieving Anusol HC Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength signature care Hydrocortisone Hydrocortisone maximum strength FixMySkin HEALING BODY BALM Fragrance-Free CVS Anti-Itch Hydrocortisone Good Neighbor Pharmacy Hydrocortisone with Aloe Dg Health Hydrocortisone Proctol Suppositories OREAD GOLD Anti-Itch Foam KAISER PERMANENTE Hydrocortisone TopCare Hydrocortisone Aquacort Lotion 2.5% Hydrocortisone Crm 1% Up and Up Hydrocortisone One Per Cent Western Family HydroCortisone Plus 12 Moisturizers Monistat Complete Care Instant Itch Relief OLP Hydrocortisone 1% Cortizone 10 Itch Relief Massaging Rollerball Quality Choice Anti Itch with Aloe Apres Peel Soothing Balm Rite Aid anti-itch Texacort Herb Street Anti-Itch Stick Healthy Accents Cortisone Maximum Strength Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Meijer Intense Healing Thera Plus Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Cooling Itch Relief Rite Aid DG health hydrocortisone SKIN A COOL Hydrocortisone Anti-Itch Hydroxym Cream Post Treatment Balm FIRST Marys Mouthwash Compounding Instant Cooling Itch Relief CVS Aloe Cort Calming Cream Medi-First Equate Hydrocortisone Intensive Healing Formula Equaline Anti Itch Maximum Strength Mycozyl HC Cream Gel Family Wellness DermaCort Anti-itch Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Scalpicin Scalp Itch Medication Maximum Strength Cortisone Maximum Strength Hydrocortisone Cortaid Intensive Therapy Cooling Hydrocortisone Continuous Dr Lift Soothing Cream S-Oint HYDROCORTISONE 1% Dr H Stabilizer Quality Choice Hydrocortisone Maximum Strength Rugby Hydrocortisone With Aloe Ala-Scalp Shopko Hydrocortisone Intensive Healing Formula Cortizone 10 Intensive Healing Hydrocortisone Maximum Strength Schein Hydrocortisone Cortisone 10 Sensitive Skin Creme Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Procto-Med HC Hemorrodil Unguento Plus OLIVIA QUIDO FIRM and FADE I Medi-First Plus Hydrocortisone Hydrocortisone 1 Hydrocortisone with Aloe Maximum Strength Winco Maximum Strength Hydrocortisone Anti Itch Maximum Strength Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Pediotic Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Topcare Hydrocortisone Hydrocortisone Iodoquinol Hydrocortisone Ointment 1% Hydrocortisone with aloe Anti-itch Feminine Care Aveeno Hydrocortisone Anti Itch Theraplex AIM Anti-Itch Moisturizing Cream Anti-Itch Scherer Labs Cortisone Plus Aloe Maximum Strength Welly Human Repair Kit BudPak Anti-Itch Hydrocaine Proctocream HC Proctocort Emo Cort Cream 2.5% Harris Teeter Anti-Itch Good Sense Anti Itch Proctosedyl Signature Care Hydrocortisone Hydrocortisone Cream Intensive Healing SeaCalm Skin Itch Relief Instant Cooling Ketocon CeraVe Anti-Itch H Plus Holdings Nourishing Soothe Rodan Fields Rexall Hydrocortisone Plus Moisturizers Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Sandoz Cortimyxin Basic Care Hydrocortisone Dermasorb AF Complete Kit Good Neighbor Pharmacy Anti Itch Itch and Rash Cream Publix hydro plus Quality Choice Maximum Strength Anti Itch Premier Value Hydrocortisone Plus 12 Moisturizers Gelmicin Hydrocortisone with Aloe Cortizone 10 Sensitive Skin Anti-itch Creme Good Neighbor Pharmacy Hydrocortisone Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Corti-Sav FixMySkin Healing Balm Vanilla Fragrance Hydrocortisone Cream 0.5% USP Hydrocortisone Maximum Strength with Aloe Intensive Healing Anti Itch Cortizone 10 Plus S-Cream HYDROCORTISONE 1% Hydrocortisone Anti Itch Odan-spor-HC Our Family Hydrocortisone with Aloe Cortane-B Hydrocortisone With Aloe Maximum Strength Hydrocortisone Ultra Strength Barmicil Anti-itch Cortizone 10 Overnight Itch Relief Total Relief Casporyn HC Hydrocortisone Maximum Strength with aloe Hydrocortisone Plus 10 Moisturizers Kirkland Signature Hydrocortisone Plus Maximum Strength Caldecort Cortaid Maximum Strength AFASSCO 1% Hydrocortisone Vioform Hydrocortisone Signature Care Anti Itch Cooling Itch Relief CVS Anti itch Berkley and Jensen Anti Itch CVS Cools Itch Fast Maximum Strength Cortisone Cream with Aloe Up and Up anti itch maximum strength Quality Choice Anti Itch Ti-U-lac HC Lotion Beard Medicated Cremo Anti-Itch Odan Proctomyxin HC Oto End 10 Neomycin and Polymyxin B Sulfates and Hydrocortisone Weeks and Leo Anti-itch Equate Hydrocortisone Topical Proctozone HC Scalpicin Anti-Itch Maximum Strength Dermazene ProCure Hydrocortisone Cream Plus Rite Aid Cortisone meijer Itch and Rash Relief Advanced Hydrocortisone Quality Choice Hydrocortisone Cortibalm Cortizone-10 Soothing Aloe Creme UEC Medical Anti-Itch Vosol HC Market Basket Anti-Itch Cream Plus Aveeno Hydrocortisone ANTI-ITCH Maximum Strength Hydrocortisone Cream with Aloe Zims Advanced Crack Creme With Hydrocortisone Cortizone 10 Anti-itch for Diabetics Skin Bioelements Immediate Comfort Hydrocortisone HydroSkin Meijer Anti Itch Cream Plus Welly Itch Fix Sunmark Hydrocortisone with Aloe Maximum Strength Anti-itch Hydrocortisone HC Shopko Maximum Strength Glytone soothe calming Anti Itch Maximum Strength Plus Insect Bite Relief WINCO Hydrocortisone Cortenema Sus 100mg/60ml Vioform Hydrocortisone Mild Texacort Solution 1% CVS Maximum Strength Feminine Anti-Itch Cream Cortaid 12-Hour Advanced Anti-Itch TrueLipids Anti-Itch Barrier Cortizone 10 Poison Ivy Relief Pads Hydrocortisone, Iodoquinol Cortizone 10 Water Resistant Colocort Up and Up Anti Itch Quality Choice Anti-Itch FixMySkin Healing Balm Vanilla Flavor Itch Stuff Rephresh Cooling Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Odan Proctomyxin HC Suppositories Shoprite Hydrocortisone Quatriderm Anti-itch Dr. Throwers Hydrotet Hydrocort Dermaquest Skin Therapy Post-Skin Resurfacing Balm Alkindi HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Hydrocortisone Ointment 0.5% Proctol Ointment Welly Excursion First Aid Kit Cortizone 10 Cooling Cream Anti-Itch NU-DERM Tolereen Anti-pruritic Healerz for Itches Avedana Hydrocortisone Cream with Aloe Petrocort Antipruritic Lip 21 Assured Leader Hydrocortisone Discount Drug Mart Anti-itch Oticin HC Ear Drops ShopRite Hydrocortisone Up and Up Hydrocortisone Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Crane Safety Hydrocortisone Hydrocortisone Micro Proctosedyl Suppositories HydroSKIN Proactiv Solution Anti-Itch Scalp Alkindi Sprinkle Hydrocortisone anti-itch plus Up and Up anti itch CVS Health Maxium Strentgh Cortisone Loesch Anti-Itch Therapy Cortef Basic Case Hydrocortisone Anti-Itch Family Wellness Maximum Strength Hydrocortisone Hydrocortisone Plus Berkley and Jensen Hydrocortisone Family Wellness Max Strength 1 Hydrocortisone Cream Harris Teeter Anti-Itch Cooling Relief Hydrocortisone Anti-Itch Neo-poly-bac Hydro HeXashield Anti Itch Cream with Healing Aloe Cortizone 10 Hydratensive Healing Anti Itch Monistat Soothing Care Itch Relief Duane Reade hydrocortisone Post peel Protectant Vitality Institute Preparation H Soothing Relief Anti-itch Harris Teeter Anti-Itch with Aloe Publix Hydro TopCare Hydrocortisone Intensive Healing Formula Anti-Itch Regular Strength Cortisone Cream Intensive Healing FIRST Dukes Mouthwash Compounding Cipro Cortizone 10 Easy Relief Care One hydrocortisone maximum strength Freds Hydrocortisone with Aloe TopCare Hydrocortisone 1% with Aloe Avedana Hydrocortisone Maximum Strength Medi-Cortisone with Aloe DG Health Hydrocortisone NeilMed Anti-Itch Anti Itch Welly First Aid Kit Cortisporin Ophthalmic Scalpicin Maximum Strength Premier Value Hydrocortisone Hydrocortisone 0.5% / Hydroquinone 6% Tecnu Corticool Hydrocortisone 1% with healing aloe hydrocortisone Iodoquinol
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402