HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Reichstein's substance M 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione Hidrocortisona Hydrocortisone 11beta-hydrocortisone Hydrocortisonum (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 4-pregnen-11β,17α,21-triol-3,20-dione 11β-hydrocortisone Cortisol 17-Hydroxycorticosterone Kendall's compound F
Brand Names	Duane Reade hydrocortisone plus 12 moisturizers Cortisone 10 Intensive Moisture Creme Hydrocortisone Cream 1% with Aloe Vera Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz Sunmark Hydrocortisone Plus Premier Value Hydrocortisone Plus 12 Moisturizers NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Hydrocortisone Crm 0.5% Quality Choice Itch Relief Cortizone 10 Cooling Equate Hydrocortisone Oti Rx meijer Hydrocortisone Cortisone HydroCortisone Intensive Healing Formula FixMySkin Healing Balm Vanilla Fragrance Colocort Good Neighbor Pharmacy Hydrocortisone meijer Itch and Rash Relief Exchange Select Hydrocortisone Emo Cort Sol 2.5% USP 999 Itch Relieving Sterex Lot Plus FixMySkin Healing Balm Unflavored Family Wellness Maximum Strength Hydrocortisone Sarna Whipped Foam Aquacort Lotion 2.5% hydrocortisone Iodoquinol Care One Hydrocortisone Maximum Strength Loesch HC-10 ANTI-ITCH THERAPY Proctosol-HC Quality Choice Hydrocortisone Maximum Strength Cortisone 10 Overnight Creme Anti-Itch Hydrocort Hydrocortisone 1% Up and Up anti itch Lucky SuperSoft MAXIMUM STRENGTH CeraVe Developed with Dermatologists Anti Itch Quality Choice Maximum Strength Anti Itch Eczema Skin Mushatts N9 Up and Up Intensive Healing Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Aveeno Hydrocortisone ANTI-ITCH Corticol-Aloe Vioform Hydrocortisone Weeks and Leo Anti-itch Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Publix hydro plus Cortizone 10 Intensive Healing for Eczema Welly Human Repair Kit Itch Fixer OREAD GOLD Anti-Itch Foam Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Meijer Anti-itch with Aloe 1% Hydrocortisone Healthy Accents Cortisone Maximum Strength ProCure Hydrocortisone Plus Calendula SeaCalm Skin Itch Relief Instant Cooling Rodan and Fields Soothe Pediadermics Eczema 2 PS-2896 Hydrocortisone Cream 1%, 0.9g Loesch Anti-Itch Therapy Anti-Itch with Aloe Medi-Cortisone with Aloe Viniferamine Hydrocortisone Cream H Plus Holdings Nourishing Cortisporin Apres Peel Soothing Balm Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Vanoxide HC Rugby Hydrocortisone With Aloe TopCare Hydrocortisone Intensive Healing Formula Cooling Itch Relief Well at Walgreens Hydrocortisone Maximum Strength Cipro Xpect Hydrocortisone Welly Excursion First Aid Kit Psoriasin Itch Control Home PapKit Acetasol HC Leader Hydrocortisone With Aloe Hydrocortisone 0.5% / Hydroquinone 6% Cortizone-10 Soothing Aloe Creme Post Treatment Balm Post-Treatment Repair Cream WINCO Hydrocortisone Our Family Hydrocortisone with Aloe HydrocortisoneLotion Calmurid HC Crm Smart Sense Anti Itch Maximum Strength Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Welly Itch Fix DG Health Hydrocortisone Maximum Strength Meijer Anti Itch Cream Plus Instant Cooling Itch Relief Auro-hydrocortisone 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Total Relief Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Scarguard MD Family Care Anti-Itch Odan Proctomyxin HC Hydrocortisone 1 Plus 10 Ala-Scalp Poison Oak Regular Strength Hydrocortisone Cream Sandoz Hydrocortisone Intensive Healing Eczema Cortizone 10 Water Resistant Good Neighbor Pharmacy Anti Itch Duane Reade Hydrocortisone Ointment 0.5% Hydrocortisone Ointment 1% Proctosedyl Suppositories Shoprite Hydrocortisone Hycort Retention Enema 100mg/60ml Bioelements Immediate Comfort Hydrocortisone Tecnu Corticool Avedana Hydrocortisone Maximum Strength Quatriderm Creme Nf CVS Cortisone Nizoral Scalp Itch Relief Caring Mills Hydrocortisone Proctozone-HC TopCare Hydrocortisone FixMySkin Healing Balm Vanilla Flavor Hydrocortisone anti-itch plus Anti-Itch Scalp Relief Maximum Strength Scalpicin Scalp Itch Medication Maximum Strength Hydrocortisone Cream USP 0.5% Audiologist Anti-itch DG Health Hydrocortisone Hydrocortisone Plus 12 Moisturizers Cortizone 10 Intensive Healing Feminine Itch Relief Alkindi Sprinkle Good Neighbor Pharmacy Hydrocortisone with Aloe Emo Cort Lotion 2.5% CeraVe Anti-Itch Cortaid Maximum Strength Pharmaskincare Multi-Gly Skin Relief Cream TheraCare Hydrocortisone Cream CareOne Anti Itch Up and Up anti itch maximum strength Hydroxate Gel Hydrocortisone Maximum Strength with Aloe SAFEWAY Hydrocortisone Plus 12 Moisturizers Leader Hydrocortisone Cortenema Sus 100mg/60ml Texacort Cortizone 10 Cooling Relief Berkley and Jensen Anti Itch First Aid Only Hydrocortisone 1% Anti-Itch FixMySkin HEALING BODY BALM Fragrance-Free Discount Drug Mart Anti-itch Barriere HC 1% BudPak Anti-Itch Barmicil Anti-itch Freds Hydrocortisone with Aloe Scalpicin Maximum Strength Harris Teeter Maximum Strength Anti-Itch signature care Hydrocortisone Neomycin, Polymyxin B Sulfates and Hydrocortisone Procto-Pak Hydrocortisone and Acetic Acid Cortizone 10 Cooling Cream Anti-Itch CVS Maximum Strength Feminine Anti-Itch Cream Aquaphor Itch Relief Hydrocortisone with Aloe Maximum Strength Maximum Strength Hydrocortisone Plus Moisturizing Aloe Cortaine -B Aqueous ShopRite Hydrocortisone Meijer Maximum Strength Anti-itch Sterex Crm Plus Up and Up Hydrocortisone Anti Itch Dermarest Eczema Medicated Alumier MD Post Procedure Kit with Hydrocortisone Maximum Strength Cortisone Cream with Aloe Neosporin Eczema Essentials Anti Itch Soothe Rodan Fields Up and Up Hydrocortisone Ti-U-lac HC Lotion Hydrocortisone, Iodoquinol Care One hydrocortisone maximum strength Cortisporin Ophthalmic Xerese CVS Anti itch Family Wellness Max Strength 1 Hydrocortisone Cream Healerz for Itches Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% Piyanping antiitch Cooling Itch Relief Rite Aid Hydrocortisone Cream 1% Hemorrodil Unguento Plus Quality Choice Anti-Itch H-Releve Anti-Itch Thera plus Anti-itch with aloe Hydrocortisone Dermazene Zims Advanced Crack Creme With Hydrocortisone Gelmicin Hydrocortisone with Aloe Cortaid Intensive Therapy Cooling Cortizone 10 for Psoriasis Post peel Protectant Vitality Institute Equate Hydrocortisone Intensive Healing Formula Rexall Anti Itch Maximum Strength Relief ECOLAB Hydrocortisone Cream Pediaderm HC Hydrocortisone Rectal Suspension (Retention) Sandoz Cortimyxin Shopko Hydrocortisone WinCo Maximum Strength Hydrocortisone Barmicil Plus Proctol Suppositories Hydrocortisone Anti-Itch Hydrocortisone 1% with healing aloe Topcare Hydrocortisone Dr. Throwers Hydrotet Hydrocortisone 1 Oto End 10 Corti-Sav Shopko Hydrocortisone Intensive Healing Formula Cortizone 10 Intensive Healing Dr H Stabilizer Intensive Healing Anti Itch Hydrocortisone Micro Medi-First Plus Hydrocortisone Hydrocortisone Intensive Healing Formula Welly Superhero Supplies Kit TopCare Hydrocortisone 1% with Aloe Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Cortibalm Quality Choice Anti Itch with Aloe Cortizone 10 Feminine Itch Relief Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Equaline Anti Itch Maximum Strength Maximum Strength Hydrocortisone Publix Hydro Yes To Coconut Eczema Relief Rexall Hydrocortisone 1 TheraCare Maximum Strength 1% Hydrocortisone Hydrocortisone Cream Intensive Healing Makesense Maximum Strength Casporyn HC Formu Care Anti Itch maximum strength Instant Cooling Itch Relief CVS Blue-Emu Anti-Itch Cream Cortate Crm 1% glo SKIN BEAUTY Remedy Gel Smart Sense Anti Itch Cortizone 10 Ultra Soothing Creme Scalpicin Anti-Itch Maximum Strength Anti-itch Feminine Care FixMySkin HEALING LIP BALM unflavoured Quadrydern Good Sense Anti Itch Cortisone maximum strength Alacort Cortizone 10 Hydratensive Healing Anti Itch Proctosedyl Sup Itch Stuff Hydrocortisone maximum strength Hydro Skin Dermoscribe Seborrheic Dermatitis Hydroxym Cream Cortizone 10 Poison Ivy Relief Pads Meijer Anti Itch Cortenema Efmody Healing Tree Calming Anti-itch Itch relief Cream Pharmaskincare Brightening Dermarelief Cream Scarguard MD Physicians Formula Odan Proctomyxin HC Suppositories Careone Hydrocortisone 1 Maximum Strength Hydrocaine Equaline Anti Itch Texacort Solution 1% Glytone soothe calming Aveeno Hydrocortisone Anti Itch Rexall Hydrocortisone Plus Moisturizers Smart Sense Hydrocortisone Ana Cool Rapid Soothing Cooling Formula TopCare Hydrocortisone Plus 12 Moisturizers Proctosedyl Members Mark Hydrocortisone Fulton Street Market Anti itch Cortef Anti-Itch Regular Strength S-Cream HYDROCORTISONE 1% Maximum-H AVON HeXashield Anti Itch Cream with Healing Aloe Monistat Complete Care Instant Itch Relief Equate Hydrocortisone Topical Petrocort Antipruritic Lip 21 Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Advanced Hydrocortisone Maximum Strength Cortizone 10 Quick Shot 360 Continuous Shopko Hydrocortisone With Aloe Cooling Itch Relief Beard Medicated Cremo Pharmaskincare Acnecare Cream HydroSkin Careone Anti Itch Cortizone 10 Hydratensive Soothing Anti Itch Aquanil HC S-Oint HYDROCORTISONE 1% Cortisone Cream Intensive Healing Hydrocortisone Plus 12 Moisturizers Maximum Strength Premier Value Hydrocortisone Poison Oak and Ivy Quatriderm Anti-itch Family Wellness 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Caldecort Insect Bite Relief ATOPALM Moisturizing Hydrocortisone Family Wellness Hydrocortisone Cortisone Maximum Strength Pediotic Hydrocortisone Cream 0.5% USP Oticin HC Ear Drops Monistat Soothing Care Itch Relief CliniCalm Maximum Strength Anti-Itch Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Rephresh Cooling Anti-itch Hydrocortisone Alkindi Cortomycin Vioform Hydrocortisone Mild ProCure Hydrocortisone Cream Plus Proctosedyl Ointment Anti Itch Maximum Strength DermaCort Anti-itch Schein Hydrocortisone Hydrocortisone Maximum Strength with aloe Rite Aid Cortisone Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Meijer Intense Healing Cortizone 10 Overnight Itch Relief NeilMed Anti-Itch Dermoscribe Ichybum CVS Cools Itch Fast OLP Hydrocortisone 1% Aloe Cort Proctozone HC Vioform + Hydrocortisone Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Walgreens Hydrocortisone Plus 12 Moisturizers Cortane-B Welly First Aid Kit Proctol Ointment Market Basket Anti-Itch Cream Plus Dermasorb AF Complete Kit CVS Anti-Itch Hydrocortisone Freds Hydrocortisone Plus 12 Moisturizers FIRST Dukes Mouthwash Compounding Hydrocortisone Crm 1% Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Hydroxym Cortizone 10 Itch Relief Massaging Rollerball UEC Medical Anti-Itch Anti Itch Maximum Strength Plus Winco Maximum Strength Hydrocortisone Cortizone 10 Easy Relief CVS Health Hydrocortisone Anti Itch Proctocream HC TrueLipids Anti-Itch Barrier KAISER PERMANENTE Hydrocortisone 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Itch Relief Dermarest Dricort 0.5% Hydrocortisone Anti-itch Aloe Cort Calming Cream Assured sunmark Hydrocortisone Neosporin Essentials Trial Pack WinCo Foods Hydrocortisone Cream Intensive Healing Cortisone Plus Aloe Maximum Strength Hydrocortisone With Aloe Maximum Strength Hydrocortisone Cream Theracort Medi-First Dr. Sheffield Hydrocortisone Anti itch Maximum Strength Hydrocortisone Cream with Aloe Anti-Itch Scherer Labs Berkley and Jensen Hydrocortisone Sunmark Hydrocortisone with Aloe Maximum Strength meijer Hydrocortisone Plus 12 Moisturizers CVS Health Maxium Strentgh Cortisone Hydrocortisone Continuous Selsun Blue Scalp Itch Treatment Smart sense Hydrocortisone Duane Reade hydrocortisone Shopko Hydrocortisone Maximum Strength Ketocon Cipro HC Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Hydrocortisone Plus 10 Moisturizers Quality Choice Anti Itch Meijer Maximum Strength Anti-itch Cream with Aloe Kirkland Signature Hydrocortisone Plus Maximum Strength Hydrocortisone with Aloe Rugby Hydroskin Hydrocortisone With Aloe Harris Teeter Anti-Itch with Aloe Hytone Family Care Hydrocortisone Pramoxine-HC Vosol HC SKIN A COOL Hydrocortisone Anti-Itch Face Values Hydrocortisone With Aloe Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Cortizone 10 Anti Itch Cortaid 12-Hour Advanced Anti-Itch Hydrocortisone 1% in Absorbase Cicatricure Ultra Moisturizing Theraplex AIM Anti-Itch Moisturizing Cream Cortizone 10 Plus Maximum Strength Cortisone Itch and Bite Relief First Aid Kit Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Aveeno Hydrocortisone Anti-itch Cream Basic Case Hydrocortisone Anti-Itch CVS Pharmacy Anti-itch Dermaquest Skin Therapy Post-Skin Resurfacing Balm Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Signature Care Anti Itch Alumier MD Intensive Recovery FixMySkin Healing Balm Fragrance-Free Western Family HydroCortisone Dg Health Hydrocortisone Western Family HydroCortisone Plus 12 Moisturizers Maximum Strength Hydrocortisone Cream Mycozyl HC Cream Gel Antibiotic Ear (Neo/Polym/HC) HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF AFASSCO 1% Hydrocortisone CVS Maximum Strength Anti-Itch Cream Cortisone 10 Sensitive Skin Creme Hydrocortisone Cream 0.5% Sarna HC Anti itch Procto-Med HC Thera Plus Harris Teeter Anti-Itch Cooling Relief Hydrocortisone 2.5% / Ketoconazole 2% Cortizone 10 Sensitive Skin Anti-itch Creme Welly Adventure First Aid Kit Basic Care Hydrocortisone Atopalm Maximum Strength Anti-Itch Harris Teeter Anti-Itch Intensive Healing Hydrocortisone HC Hydrocortisone Iodoquinol 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Preparation H Soothing Relief Anti-itch Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Hydrocortisone with aloe Cortizone 10 Anti-itch for Diabetics Skin Hydrocortisone Plus Mycozyl HC HeXashield Anti Itch Cream with Healing Aloe FIRST Marys Mouthwash Compounding Natureplex Hydrocortisone Hydro Up and Up Hydrocortisone One Per Cent Proactiv Solution Anti-Itch Scalp Live Better Hydrocortisone with Aloe Preparation H Hydrocortisone Signature Care Hydrocortisone Cipro HC Otic Suspension Up and Up Anti Itch Hydrocortisone Regular Strength Medi-First Hydrocortisone Meijer Maximum Strength Anti-itch Cream wiith Aloe Cho-A Care Lot 1% Alcortin Refuge HC Cvs Hydrocortisone With Aloe Hydrocortisone Anti Itch Neomycin and Polymyxin B Sulfates and Hydrocortisone Crane Safety Hydrocortisone NU-DERM Tolereen Anti-pruritic Bencort Ala Quin TrueLipids 1% Hydrocortisone Barrier Cream HydroSKIN Dr Lift Soothing Cream Rite Aid anti-itch OLIVIA QUIDO FIRM and FADE II Kera HC OLIVIA QUIDO FIRM and FADE I Triple Antibiotic HC Quality Choice Hydrocortisone DG health hydrocortisone Anusol HC Hydro Ear Plenadren Neo-poly-bac Hydro Herb Street Anti-Itch Stick Itch and Rash Cream Hydrocortisone D Odan-spor-HC Hydrocortisone Ultra Strength Green Guard Maximum Strength Hydrocortisone Shopko Maximum Strength Avedana Hydrocortisone Cream with Aloe Proctocort Harris Teeter Anti-Itch Hydrocortisone Butyrate Cortate Ont 1% Emo Cort Cream 2.5%
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402